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Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron (heme A axial ligand)By similarity1
Metal bindingi258Copper BBy similarity1
Metal bindingi262Copper BBy similarity1
Metal bindingi307Copper BBy similarity1
Metal bindingi308Copper BBy similarity1
Metal bindingi393Iron (heme A3 axial ligand)By similarity1
Metal bindingi395Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RF_0627
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002808851 – 532Probable cytochrome c oxidase subunit 1Add BLAST532

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0627

Structurei

3D structure databases

ProteinModelPortaliQ4ULU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085275
KOiK02274
OMAiYLMILPI
OrthoDBiPOG091H042R

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ULU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITTTEIYH DDHHTPHGWK RWLFSTNHKD IGIMYIIFAV FAGIVGGLFS
60 70 80 90 100
LLFRLELAMP GGTFLNHDFQ LYNVLITAHA VIMVFFMIMP ALFGGFGNYF
110 120 130 140 150
VPLLIGAPDM AFPRLNNISF WLLVTAFILL MGSAFVDGGP GTGWTLYPPL
160 170 180 190 200
SNLSGHPGAA VDMAIFSLHL TGLSSILGSI NLIVTIFNMR APGMGLFKMP
210 220 230 240 250
LFVWSILVTA FLIILAMPVL GGAITMLLTD RNFGTNFFKP DGGGDPVLFQ
260 270 280 290 300
HLFWFFGHPE VYIVILPGFG IVSQVISTFS RKPIFGYQGM VGAMVIIGFV
310 320 330 340 350
GFIVWAHHMF TVGLSYNALI YFTAGTMIIA VPTGIKIFSW IATMWGGSIT
360 370 380 390 400
FPTPMLFSIG FIILFTIGGV TGIILSNSAL DRVLHDTYYV VAHFHYTMSL
410 420 430 440 450
GALFTAFAGF YYWFGKISGK QYPEILGKIH FWITFIGVNL TFFPQHFLGL
460 470 480 490 500
AGMPRRIPDY PEAFAGWNMV SSIGAGISMA AALYFVFIVF YTLKYGKDCP
510 520 530
NNPWGDGADT LEWTLTSPPP FHTFETPPHI EG
Length:532
Mass (Da):58,834
Last modified:July 5, 2005 - v1
Checksum:i8DB5305BDF07B274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61478.1
RefSeqiWP_011270957.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61478; AAY61478; RF_0627
KEGGirfe:RF_0627

Similar proteinsi

Entry informationi

Entry nameiCOX1_RICFE
AccessioniPrimary (citable) accession number: Q4ULU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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