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Q4ULU5

- COX1_RICFE

UniProt

Q4ULU5 - COX1_RICFE

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Protein
Probable cytochrome c oxidase subunit 1
Gene
ctaD, coxA, RF_0627
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Iron (heme A axial ligand) By similarity
Metal bindingi258 – 2581Copper B By similarity
Metal bindingi262 – 2621Copper B By similarity
Metal bindingi307 – 3071Copper B By similarity
Metal bindingi308 – 3081Copper B By similarity
Metal bindingi393 – 3931Iron (heme A3 axial ligand) By similarity
Metal bindingi395 – 3951Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-644-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RF_0627
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei200 – 22021Helical; Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Reviewed prediction
Add
BLAST
Transmembranei355 – 37521Helical; Reviewed prediction
Add
BLAST
Transmembranei394 – 41421Helical; Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Transmembranei473 – 49321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Probable cytochrome c oxidase subunit 1
PRO_0000280885Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0627.

Structurei

3D structure databases

ProteinModelPortaliQ4ULU5.
SMRiQ4ULU5. Positions 19-531.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02274.
OMAiMGMTRRV.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULU5-1 [UniParc]FASTAAdd to Basket

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MDITTTEIYH DDHHTPHGWK RWLFSTNHKD IGIMYIIFAV FAGIVGGLFS    50
LLFRLELAMP GGTFLNHDFQ LYNVLITAHA VIMVFFMIMP ALFGGFGNYF 100
VPLLIGAPDM AFPRLNNISF WLLVTAFILL MGSAFVDGGP GTGWTLYPPL 150
SNLSGHPGAA VDMAIFSLHL TGLSSILGSI NLIVTIFNMR APGMGLFKMP 200
LFVWSILVTA FLIILAMPVL GGAITMLLTD RNFGTNFFKP DGGGDPVLFQ 250
HLFWFFGHPE VYIVILPGFG IVSQVISTFS RKPIFGYQGM VGAMVIIGFV 300
GFIVWAHHMF TVGLSYNALI YFTAGTMIIA VPTGIKIFSW IATMWGGSIT 350
FPTPMLFSIG FIILFTIGGV TGIILSNSAL DRVLHDTYYV VAHFHYTMSL 400
GALFTAFAGF YYWFGKISGK QYPEILGKIH FWITFIGVNL TFFPQHFLGL 450
AGMPRRIPDY PEAFAGWNMV SSIGAGISMA AALYFVFIVF YTLKYGKDCP 500
NNPWGDGADT LEWTLTSPPP FHTFETPPHI EG 532
Length:532
Mass (Da):58,834
Last modified:July 5, 2005 - v1
Checksum:i8DB5305BDF07B274
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61478.1.
RefSeqiYP_246643.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61478; AAY61478; RF_0627.
GeneIDi3400398.
KEGGirfe:RF_0627.
PATRICi17891840. VBIRicFel64634_0749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61478.1 .
RefSeqi YP_246643.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4ULU5.
SMRi Q4ULU5. Positions 19-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61478 ; AAY61478 ; RF_0627 .
GeneIDi 3400398.
KEGGi rfe:RF_0627.
PATRICi 17891840. VBIRicFel64634_0749.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02274.
OMAi MGMTRRV.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci RFEL315456:GKEK-644-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCOX1_RICFE
AccessioniPrimary (citable) accession number: Q4ULU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi