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Q4ULU3 (COX2_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RF_0629
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Contains 1 RPE1 insert domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Probable cytochrome c oxidase subunit 2
PRO_0000280887

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane133 – 15321Helical; Potential
Domain6 – 5348RPE1 insert

Sites

Metal binding2351Copper A Potential
Metal binding2701Copper A Potential
Metal binding2741Copper A Potential
Metal binding2781Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q4ULU3 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: B8DFA39883B841E8

FASTA31535,674
        10         20         30         40         50         60 
MKNIIRHLSK PAYREEFKGD TSPRTAAYIS NRADASLGST YKLPLEAKFW KMSIALICFL 

        70         80         90        100        110        120 
IVSSNCFASE PLPWQVTFQP PASPIMEELH HFHNFLLYIS TAIVLFVAGL LGFVCIRFNA 

       130        140        150        160        170        180 
KNNPVPAKFS HNVLIEIIWT VIPIIILVII AVPSFRILRH AEKIPETDLT IKVVGYQWYW 

       190        200        210        220        230        240 
HYIYPDHDNL EFDSVMISDE NLKPDQKRLL DVDNRIVIPE NATVRFLITA GDVIHSFAVP 

       250        260        270        280        290        300 
SLGFKIDAVP GRINETWTRV AKKGVYYGQC SELCGINHGF MPIAIEVVSK EDFDNWIASK 

       310 
NKTAMNGKNP KLAAN 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61480.1.
RefSeqYP_246645.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0629.

Proteomic databases

PRIDEQ4ULU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61480; AAY61480; RF_0629.
GeneID3400400.
KEGGrfe:RF_0629.
PATRIC17891846. VBIRicFel64634_0752.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02275.
OMADNWIASK.
OrthoDBEOG68SVXT.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-646-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_RICFE
AccessionPrimary (citable) accession number: Q4ULU3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names