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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi235Copper ASequence analysis1
Metal bindingi270Copper ASequence analysis1
Metal bindingi274Copper ASequence analysis1
Metal bindingi278Copper ASequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RF_0629
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002808871 – 315Probable cytochrome c oxidase subunit 2Add BLAST315

Proteomic databases

PRIDEiQ4ULU3.

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0629.

Structurei

3D structure databases

ProteinModelPortaliQ4ULU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 53RPE1 insertAdd BLAST48

Sequence similaritiesi

Contains 1 RPE1 insert domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000264988.
KOiK02275.
OMAiFMPIAIR.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIIRHLSK PAYREEFKGD TSPRTAAYIS NRADASLGST YKLPLEAKFW
60 70 80 90 100
KMSIALICFL IVSSNCFASE PLPWQVTFQP PASPIMEELH HFHNFLLYIS
110 120 130 140 150
TAIVLFVAGL LGFVCIRFNA KNNPVPAKFS HNVLIEIIWT VIPIIILVII
160 170 180 190 200
AVPSFRILRH AEKIPETDLT IKVVGYQWYW HYIYPDHDNL EFDSVMISDE
210 220 230 240 250
NLKPDQKRLL DVDNRIVIPE NATVRFLITA GDVIHSFAVP SLGFKIDAVP
260 270 280 290 300
GRINETWTRV AKKGVYYGQC SELCGINHGF MPIAIEVVSK EDFDNWIASK
310
NKTAMNGKNP KLAAN
Length:315
Mass (Da):35,674
Last modified:July 5, 2005 - v1
Checksum:iB8DFA39883B841E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61480.1.
RefSeqiWP_011270959.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61480; AAY61480; RF_0629.
KEGGirfe:RF_0629.
PATRICi17891846. VBIRicFel64634_0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61480.1.
RefSeqiWP_011270959.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4ULU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0629.

Proteomic databases

PRIDEiQ4ULU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61480; AAY61480; RF_0629.
KEGGirfe:RF_0629.
PATRICi17891846. VBIRicFel64634_0752.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000264988.
KOiK02275.
OMAiFMPIAIR.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_RICFE
AccessioniPrimary (citable) accession number: Q4ULU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.