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Q4ULS5

- SYFA_RICFE

UniProt

Q4ULS5 - SYFA_RICFE

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

    Cofactori

    Binds 2 magnesium ions per tetramer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi258 – 2581MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-664-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
    Short name:
    PheRSUniRule annotation
    Gene namesi
    Name:pheSUniRule annotation
    Ordered Locus Names:RF_0647
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Phenylalanine--tRNA ligase alpha subunitPRO_0000232021Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0647.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0016.
    HOGENOMiHOG000242675.
    KOiK01889.
    OMAiMGKELNS.
    OrthoDBiEOG6WX4QN.

    Family and domain databases

    HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00468. pheS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ULS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENIETILRL AEEKILLVQN LKELQEYKVE FLGKNGIVTG ELKKLGSLNE    50
    QERKEFGLKI NKLKDKIQNI IKAKEEILEE QELNLKLAAD KIDLTIPARR 100
    YKQGSIHPIT QCSEELIQVF SQFGFTIENG PNIENDFHNF TSLNFEDDHP 150
    ARQMHDTFYL KGQENNKPLL LRTHTSTVQI RAMKNGKPPF RFIAPGRTYR 200
    SDSDMTHTPM FHQIEGLVID KNINMGHLKY VITEFIKSFF ENSNIELRFR 250
    PSFFPFTEPS AEVDIRMNKN DKWLEVLGCG MVHPNVLKNV GIDSSEYQGF 300
    AFGLGVERFA MLKYNIKDLR QFFEGDMRWL KHYNFGSFDI PNLAGGLTK 349
    Length:349
    Mass (Da):40,484
    Last modified:April 4, 2006 - v2
    Checksum:i5D7BA4BD0B739DCD
    GO

    Sequence cautioni

    The sequence AAY61498.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61498.1. Different initiation.
    RefSeqiYP_246663.2. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61498; AAY61498; RF_0647.
    GeneIDi3400655.
    KEGGirfe:RF_0647.
    PATRICi17891890. VBIRicFel64634_0774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61498.1 . Different initiation.
    RefSeqi YP_246663.2. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0647.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61498 ; AAY61498 ; RF_0647 .
    GeneIDi 3400655.
    KEGGi rfe:RF_0647.
    PATRICi 17891890. VBIRicFel64634_0774.

    Phylogenomic databases

    eggNOGi COG0016.
    HOGENOMi HOG000242675.
    KOi K01889.
    OMAi MGKELNS.
    OrthoDBi EOG6WX4QN.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-664-MONOMER.

    Family and domain databases

    HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00468. pheS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSYFA_RICFE
    AccessioniPrimary (citable) accession number: Q4ULS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3