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Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi258MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheSUniRule annotation
Ordered Locus Names:RF_0647
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002320211 – 349Phenylalanine--tRNA ligase alpha subunitAdd BLAST349

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0647

Structurei

3D structure databases

ProteinModelPortaliQ4ULS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSS Bacteria
COG0016 LUCA
HOGENOMiHOG000242675
KOiK01889
OrthoDBiPOG091H00QY

Family and domain databases

HAMAPiMF_00281 Phe_tRNA_synth_alpha1, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004529 Phe-tRNA-synth_IIc_asu
IPR004188 Phe-tRNA_ligase_II_N
IPR022911 Phe_tRNA_ligase_alpha1_bac
IPR002319 Phenylalanyl-tRNA_Synthase
IPR010978 tRNA-bd_arm
PANTHERiPTHR11538:SF48 PTHR11538:SF48, 1 hit
PfamiView protein in Pfam
PF02912 Phe_tRNA-synt_N, 1 hit
PF01409 tRNA-synt_2d, 1 hit
SUPFAMiSSF46589 SSF46589, 1 hit
TIGRFAMsiTIGR00468 pheS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ULS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENIETILRL AEEKILLVQN LKELQEYKVE FLGKNGIVTG ELKKLGSLNE
60 70 80 90 100
QERKEFGLKI NKLKDKIQNI IKAKEEILEE QELNLKLAAD KIDLTIPARR
110 120 130 140 150
YKQGSIHPIT QCSEELIQVF SQFGFTIENG PNIENDFHNF TSLNFEDDHP
160 170 180 190 200
ARQMHDTFYL KGQENNKPLL LRTHTSTVQI RAMKNGKPPF RFIAPGRTYR
210 220 230 240 250
SDSDMTHTPM FHQIEGLVID KNINMGHLKY VITEFIKSFF ENSNIELRFR
260 270 280 290 300
PSFFPFTEPS AEVDIRMNKN DKWLEVLGCG MVHPNVLKNV GIDSSEYQGF
310 320 330 340
AFGLGVERFA MLKYNIKDLR QFFEGDMRWL KHYNFGSFDI PNLAGGLTK
Length:349
Mass (Da):40,484
Last modified:April 4, 2006 - v2
Checksum:i5D7BA4BD0B739DCD
GO

Sequence cautioni

The sequence AAY61498 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61498.1 Different initiation.
RefSeqiWP_011270977.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61498; AAY61498; RF_0647
KEGGirfe:RF_0647

Similar proteinsi

Entry informationi

Entry nameiSYFA_RICFE
AccessioniPrimary (citable) accession number: Q4ULS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: April 25, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health