Reviewed, UniProtKB/Swiss-Prot Q4ULR7 (CDSA_RICFE)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	RF_0655

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Phosphatidate cytidylyltransferase		PRO_0000281058
Regions
	Transmembrane	31 – 51	21	Potential
	Transmembrane	65 – 85	21	Potential
	Transmembrane	93 – 113	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	206 – 226	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4ULR7-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 44E64F36CDE950FE	FASTA	227	25,624
	10 20 30 40 50 60 MITQKGKEHL AKDKQNIYLR ILSGIVLVPL FVIAILWFKP LFYILMILVG MGMLSEWYNM 70 80 90 100 110 120 TYSSIPYLLI GLIIIPIPIS LLTFLSMEDT NRWLIMLYFC IIWSVDSFAM IGGKTFKGAK 130 140 150 160 170 180 LAPKISPKKT WSGLVTGVLS AGLVAVLASF IPNFHIENYY FSNKIYLFII SCILALIAQS 190 200 210 220 SDLFISYLKR KFNIKDSGHI IPGHGGVLDR FDSIILTAPV LFFISIL

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY61506.1.
RefSeq	YP_246671.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400663.
GenomeReviews	Gene locus RF_0655 in contig CP000053_GR.
KEGG	rfe:RF_0655.
NMPDR	fig|315456.3.peg.566.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4ULR7.
OMA	Q4ULR7. MEDTNRW.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0655-MON.
BRENDA	2.7.7.41. 297363.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICFE

Accession

Primary (citable) accession number: Q4ULR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)