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Protein

Isoprenyl transferase

Gene

uppS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei21UniRule annotation1
Metal bindingi21MagnesiumUniRule annotation1
Binding sitei26SubstrateUniRule annotation1
Binding sitei34SubstrateUniRule annotation1
Binding sitei38SubstrateUniRule annotation1
Active sitei69Proton acceptorUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei72SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Metal bindingi202MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:RF_0656
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236621 – 235Isoprenyl transferaseAdd BLAST235

Proteomic databases

PRIDEiQ4ULR6

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0656

Structurei

3D structure databases

ProteinModelPortaliQ4ULR6
SMRiQ4ULR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 25Substrate bindingUniRule annotation4
Regioni66 – 68Substrate bindingUniRule annotation3
Regioni189 – 191Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3 Bacteria
COG0020 LUCA
HOGENOMiHOG000006054
KOiK00806
OMAiFDRRDLW
OrthoDBiPOG091H00BZ

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ULR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQHLKYKIM TNIKHLAIIM DGNARWADQH NLTKSEGHKA GADKIRELLP
60 70 80 90 100
EFINLNIPYI TLYTFSSENW QRSSTEVDFL IKLLSIYFKN ELNSLHKNGV
110 120 130 140 150
KIKVIGRLNL LSSSLQKQIN NAIELTKNNN KITLCIAFSY GSRQEIVDAC
160 170 180 190 200
TKIIASGKKE ISESDIGHAL YDPEMPDVDL LIRPGGVYRI SNFLLWQAAY
210 220 230
AELYFSPKYW PAFNKDDIIE AINDYSKRKR TFGKR
Length:235
Mass (Da):27,060
Last modified:July 5, 2005 - v1
Checksum:i86B98E70DCF32C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61507.1

Genome annotation databases

EnsemblBacteriaiAAY61507; AAY61507; RF_0656
KEGGirfe:RF_0656

Entry informationi

Entry nameiISPT_RICFE
AccessioniPrimary (citable) accession number: Q4ULR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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