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Protein

Isoprenyl transferase

Gene

uppS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei21 – 211UniRule annotation
Metal bindingi21 – 211MagnesiumUniRule annotation
Binding sitei26 – 261SubstrateUniRule annotation
Binding sitei34 – 341SubstrateUniRule annotation
Binding sitei38 – 381SubstrateUniRule annotation
Active sitei69 – 691Proton acceptorUniRule annotation
Binding sitei70 – 701SubstrateUniRule annotation
Binding sitei72 – 721SubstrateUniRule annotation
Binding sitei183 – 1831SubstrateUniRule annotation
Metal bindingi202 – 2021MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:RF_0656
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Isoprenyl transferasePRO_0000123662Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0656.

Structurei

3D structure databases

ProteinModelPortaliQ4ULR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 254Substrate bindingUniRule annotation
Regioni66 – 683Substrate bindingUniRule annotation
Regioni189 – 1913Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQHLKYKIM TNIKHLAIIM DGNARWADQH NLTKSEGHKA GADKIRELLP
60 70 80 90 100
EFINLNIPYI TLYTFSSENW QRSSTEVDFL IKLLSIYFKN ELNSLHKNGV
110 120 130 140 150
KIKVIGRLNL LSSSLQKQIN NAIELTKNNN KITLCIAFSY GSRQEIVDAC
160 170 180 190 200
TKIIASGKKE ISESDIGHAL YDPEMPDVDL LIRPGGVYRI SNFLLWQAAY
210 220 230
AELYFSPKYW PAFNKDDIIE AINDYSKRKR TFGKR
Length:235
Mass (Da):27,060
Last modified:July 5, 2005 - v1
Checksum:i86B98E70DCF32C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61507.1.

Genome annotation databases

EnsemblBacteriaiAAY61507; AAY61507; RF_0656.
KEGGirfe:RF_0656.
PATRICi17891914. VBIRicFel64634_0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61507.1.

3D structure databases

ProteinModelPortaliQ4ULR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61507; AAY61507; RF_0656.
KEGGirfe:RF_0656.
PATRICi17891914. VBIRicFel64634_0786.

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-673-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiISPT_RICFE
AccessioniPrimary (citable) accession number: Q4ULR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.