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Q4ULR6 (ISPT_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isoprenyl transferase

EC=2.5.1.-
Gene names
Name:uppS
Ordered Locus Names:RF_0656
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_01139

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01139

Sequence similarities

Belongs to the UPP synthase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

prenyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Isoprenyl transferase HAMAP-Rule MF_01139
PRO_0000123662

Regions

Region22 – 254Substrate binding By similarity
Region66 – 683Substrate binding By similarity
Region189 – 1913Substrate binding By similarity

Sites

Active site211 By similarity
Active site691Proton acceptor By similarity
Metal binding211Magnesium By similarity
Metal binding2021Magnesium By similarity
Binding site261Substrate By similarity
Binding site341Substrate By similarity
Binding site381Substrate By similarity
Binding site701Substrate By similarity
Binding site721Substrate By similarity
Binding site1831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4ULR6 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 86B98E70DCF32C55

FASTA23527,060
        10         20         30         40         50         60 
MQQHLKYKIM TNIKHLAIIM DGNARWADQH NLTKSEGHKA GADKIRELLP EFINLNIPYI 

        70         80         90        100        110        120 
TLYTFSSENW QRSSTEVDFL IKLLSIYFKN ELNSLHKNGV KIKVIGRLNL LSSSLQKQIN 

       130        140        150        160        170        180 
NAIELTKNNN KITLCIAFSY GSRQEIVDAC TKIIASGKKE ISESDIGHAL YDPEMPDVDL 

       190        200        210        220        230 
LIRPGGVYRI SNFLLWQAAY AELYFSPKYW PAFNKDDIIE AINDYSKRKR TFGKR 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61507.1.
RefSeqYP_246672.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61507; AAY61507; RF_0656.
GeneID3400664.
KEGGrfe:RF_0656.
PATRIC17891914. VBIRicFel64634_0786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0020.
HOGENOMHOG000006054.
KOK00806.
OMANRPEQEV.
OrthoDBEOG68H89T.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-673-MONOMER.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. ISPT.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. SSF64005. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPT_RICFE
AccessionPrimary (citable) accession number: Q4ULR6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names