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Q4ULR6

- ISPT_RICFE

UniProt

Q4ULR6 - ISPT_RICFE

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Protein
Isoprenyl transferase
Gene
uppS, RF_0656
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei21 – 211 By similarity
Metal bindingi21 – 211Magnesium By similarity
Binding sitei26 – 261Substrate By similarity
Binding sitei34 – 341Substrate By similarity
Binding sitei38 – 381Substrate By similarity
Active sitei69 – 691Proton acceptor By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei72 – 721Substrate By similarity
Binding sitei183 – 1831Substrate By similarity
Metal bindingi202 – 2021Magnesium By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. prenyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-673-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoprenyl transferase (EC:2.5.1.-)
    Gene namesi
    Name:uppS
    Ordered Locus Names:RF_0656
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Isoprenyl transferaseUniRule annotation
    PRO_0000123662Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0656.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULR6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 254Substrate binding By similarity
    Regioni66 – 683Substrate binding By similarity
    Regioni189 – 1913Substrate binding By similarity

    Sequence similaritiesi

    Belongs to the UPP synthase family.

    Phylogenomic databases

    eggNOGiCOG0020.
    HOGENOMiHOG000006054.
    KOiK00806.
    OMAiNRPEQEV.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ULR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQHLKYKIM TNIKHLAIIM DGNARWADQH NLTKSEGHKA GADKIRELLP    50
    EFINLNIPYI TLYTFSSENW QRSSTEVDFL IKLLSIYFKN ELNSLHKNGV 100
    KIKVIGRLNL LSSSLQKQIN NAIELTKNNN KITLCIAFSY GSRQEIVDAC 150
    TKIIASGKKE ISESDIGHAL YDPEMPDVDL LIRPGGVYRI SNFLLWQAAY 200
    AELYFSPKYW PAFNKDDIIE AINDYSKRKR TFGKR 235
    Length:235
    Mass (Da):27,060
    Last modified:July 5, 2005 - v1
    Checksum:i86B98E70DCF32C55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61507.1.
    RefSeqiYP_246672.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61507; AAY61507; RF_0656.
    GeneIDi3400664.
    KEGGirfe:RF_0656.
    PATRICi17891914. VBIRicFel64634_0786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61507.1 .
    RefSeqi YP_246672.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULR6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61507 ; AAY61507 ; RF_0656 .
    GeneIDi 3400664.
    KEGGi rfe:RF_0656.
    PATRICi 17891914. VBIRicFel64634_0786.

    Phylogenomic databases

    eggNOGi COG0020.
    HOGENOMi HOG000006054.
    KOi K00806.
    OMAi NRPEQEV.
    OrthoDBi EOG68H89T.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-673-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiISPT_RICFE
    AccessioniPrimary (citable) accession number: Q4ULR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: July 5, 2005
    Last modified: May 14, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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