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Protein

Probable branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts on leucine, isoleucine and valine.By similarity

Catalytic activityi

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. L-isoleucine transaminase activity Source: UniProtKB-EC
  2. L-leucine transaminase activity Source: UniProtKB-EC
  3. L-valine transaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. leucine biosynthetic process Source: UniProtKB-UniPathway
  3. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-676-MONOMER.
UniPathwayiUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable branched-chain-amino-acid aminotransferase (EC:2.6.1.42)
Short name:
BCAT
Gene namesi
Name:ilvE
Ordered Locus Names:RF_0659
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Probable branched-chain-amino-acid aminotransferasePRO_0000280901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0659.

Structurei

3D structure databases

ProteinModelPortaliQ4ULR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0115.
HOGENOMiHOG000276706.
KOiK00826.
OMAiCTGANVF.
OrthoDBiEOG67MF3R.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005785. B_amino_transI.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.
TIGRFAMsiTIGR01122. ilvE_I. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMIKLEQIF WHVWINGDLV PYQFARIHVL THSLHYSGSV FEGERAYNGK
60 70 80 90 100
VFKLKEHTER LIKSAEALGL KVPYSVDEII KAHELVIKQN NIKDAYIRPL
110 120 130 140 150
IWCGDESLNI TNPDLSTNLL IAGIPSMPRS FEKGINLHVG RWRKAIPDST
160 170 180 190 200
PVQSKSAAQY NMAITSKKEA KALGYDDALL LDYEGYIAEC TTTNIFFVKD
210 220 230 240 250
KTLYTPIADR FLNGITRQTI IEIAKDLGLE VKEERLKLEQ IENFTGCFVT
260 270 280 290
GTAIEVQNID SIDLGNKKIT FDDHQIADRL KKEYGRIVRE
Length:290
Mass (Da):33,046
Last modified:July 5, 2005 - v1
Checksum:iD1C631A4DBDEF5F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61510.1.
RefSeqiWP_011270989.1. NC_007109.1.
YP_246675.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61510; AAY61510; RF_0659.
GeneIDi3400667.
KEGGirfe:RF_0659.
PATRICi17891924. VBIRicFel64634_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61510.1.
RefSeqiWP_011270989.1. NC_007109.1.
YP_246675.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4ULR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0659.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61510; AAY61510; RF_0659.
GeneIDi3400667.
KEGGirfe:RF_0659.
PATRICi17891924. VBIRicFel64634_0791.

Phylogenomic databases

eggNOGiCOG0115.
HOGENOMiHOG000276706.
KOiK00826.
OMAiCTGANVF.
OrthoDBiEOG67MF3R.

Enzyme and pathway databases

UniPathwayiUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.
BioCyciRFEL315456:GKEK-676-MONOMER.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005785. B_amino_transI.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.
TIGRFAMsiTIGR01122. ilvE_I. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiILVE_RICFE
AccessioniPrimary (citable) accession number: Q4ULR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: February 4, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.