Q4ULQ8 (SUCD_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name=SCS-alpha

Gene names

Name:	sucD
Ordered Locus Names:	RF_0664

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Succinyl-CoA ligase [ADP-forming] subunit alpha		PRO_0000286489
Sites
	Active site	248	1	Tele-phosphohistidine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4ULQ8 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: F26E7227B10DD277	FASTA	292	30,165
	10 20 30 40 50 60 MAILINKKTK VICQGFTGSQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLD LPVYNTVHEA 70 80 90 100 110 120 KAKTGANASV IYVPPGFAAD SILEAIDAEI EVVVCITEGI PVLDMVKVKR ALVGSKTRLI 130 140 150 160 170 180 GPNCPGVITP GECKIGIMPG HIHKRGTIGI VSRSGTLTYE AVAQTTAVGL GQSTCVGIGG 190 200 210 220 230 240 DPVNGTNFVD CIDMFLKDDE TKAIIMIGEI GGNAEEDAAE FIKQSKIKKP IVSFIAGITA 250 260 270 280 290 PPGKRMGHAG AIIAGGKGSA EDKLEALQSA GVTITRSPAD IGKTMFDLLN KG

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61515.1.
RefSeq	YP_246680.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 1EUD based on UniProtKB O19069.
ProteinModelPortal	Q4ULQ8.
SMR	Q4ULQ8. Positions 2-289.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0664.
Proteomic databases
PRIDE	Q4ULQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61515; AAY61515; RF_0664.
GeneID	3401289.
KEGG	rfe:RF_0664.
PATRIC	17891938. VBIRicFel64634_0798.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0074.
HOGENOM	HOG000239685.
KO	K01902.
OMA	KGRKKPM.
ProtClustDB	PRK05678.
Family and domain databases
Gene3D	3.40.50.261. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Pfam	PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001553. SucCS_alpha. 1 hit.
PRINTS	PR01798. SCOASYNTHASE.
SMART	SM00881. CoA_binding. 1 hit. [Graphical view]
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01019. sucCoAalpha. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCD_RICFE

Accession

Primary (citable) accession number: Q4ULQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program