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Q4ULQ8

- SUCD_RICFE

UniProt

Q4ULQ8 - SUCD_RICFE

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Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481Tele-phosphohistidine intermediateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP citrate synthase activity Source: InterPro
  3. cofactor binding Source: InterPro
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-681-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha (EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name:
SCS-alpha
Gene namesi
Name:sucD
Ordered Locus Names:RF_0664
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Succinyl-CoA ligase [ADP-forming] subunit alphaPRO_0000286489Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4ULQ8.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi315456.RF_0664.

Structurei

3D structure databases

ProteinModelPortaliQ4ULQ8.
SMRiQ4ULQ8. Positions 2-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiFEQDPQT.
OrthoDBiEOG644ZT0.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAILINKKTK VICQGFTGSQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLD
60 70 80 90 100
LPVYNTVHEA KAKTGANASV IYVPPGFAAD SILEAIDAEI EVVVCITEGI
110 120 130 140 150
PVLDMVKVKR ALVGSKTRLI GPNCPGVITP GECKIGIMPG HIHKRGTIGI
160 170 180 190 200
VSRSGTLTYE AVAQTTAVGL GQSTCVGIGG DPVNGTNFVD CIDMFLKDDE
210 220 230 240 250
TKAIIMIGEI GGNAEEDAAE FIKQSKIKKP IVSFIAGITA PPGKRMGHAG
260 270 280 290
AIIAGGKGSA EDKLEALQSA GVTITRSPAD IGKTMFDLLN KG
Length:292
Mass (Da):30,165
Last modified:July 5, 2005 - v1
Checksum:iF26E7227B10DD277
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61515.1.
RefSeqiWP_011270994.1. NC_007109.1.
YP_246680.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61515; AAY61515; RF_0664.
GeneIDi3401289.
KEGGirfe:RF_0664.
PATRICi17891938. VBIRicFel64634_0798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61515.1 .
RefSeqi WP_011270994.1. NC_007109.1.
YP_246680.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4ULQ8.
SMRi Q4ULQ8. Positions 2-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0664.

Proteomic databases

PRIDEi Q4ULQ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61515 ; AAY61515 ; RF_0664 .
GeneIDi 3401289.
KEGGi rfe:RF_0664.
PATRICi 17891938. VBIRicFel64634_0798.

Phylogenomic databases

eggNOGi COG0074.
HOGENOMi HOG000239685.
KOi K01902.
OMAi FEQDPQT.
OrthoDBi EOG644ZT0.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-681-MONOMER.

Family and domain databases

Gene3Di 3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
Pfami PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
PRINTSi PR01798. SCOASYNTHASE.
SMARTi SM00881. CoA_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF52210. SSF52210. 1 hit.
TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSUCD_RICFE
AccessioniPrimary (citable) accession number: Q4ULQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3