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Q4ULQ8

- SUCD_RICFE

UniProt

Q4ULQ8 - SUCD_RICFE

Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei248 – 2481Tele-phosphohistidine intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP citrate synthase activity Source: InterPro
    3. cofactor binding Source: InterPro
    4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-681-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit alpha (EC:6.2.1.5)
    Alternative name(s):
    Succinyl-CoA synthetase subunit alpha
    Short name:
    SCS-alpha
    Gene namesi
    Name:sucD
    Ordered Locus Names:RF_0664
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Succinyl-CoA ligase [ADP-forming] subunit alphaPRO_0000286489Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4ULQ8.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_0664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULQ8.
    SMRiQ4ULQ8. Positions 2-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0074.
    HOGENOMiHOG000239685.
    KOiK01902.
    OMAiFEQDPQT.
    OrthoDBiEOG644ZT0.

    Family and domain databases

    Gene3Di3.40.50.261. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view]
    PfamiPF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
    PRINTSiPR01798. SCOASYNTHASE.
    SMARTiSM00881. CoA_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF52210. SSF52210. 1 hit.
    TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
    PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ULQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAILINKKTK VICQGFTGSQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLD    50
    LPVYNTVHEA KAKTGANASV IYVPPGFAAD SILEAIDAEI EVVVCITEGI 100
    PVLDMVKVKR ALVGSKTRLI GPNCPGVITP GECKIGIMPG HIHKRGTIGI 150
    VSRSGTLTYE AVAQTTAVGL GQSTCVGIGG DPVNGTNFVD CIDMFLKDDE 200
    TKAIIMIGEI GGNAEEDAAE FIKQSKIKKP IVSFIAGITA PPGKRMGHAG 250
    AIIAGGKGSA EDKLEALQSA GVTITRSPAD IGKTMFDLLN KG 292
    Length:292
    Mass (Da):30,165
    Last modified:July 5, 2005 - v1
    Checksum:iF26E7227B10DD277
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61515.1.
    RefSeqiWP_011270994.1. NC_007109.1.
    YP_246680.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61515; AAY61515; RF_0664.
    GeneIDi3401289.
    KEGGirfe:RF_0664.
    PATRICi17891938. VBIRicFel64634_0798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61515.1 .
    RefSeqi WP_011270994.1. NC_007109.1.
    YP_246680.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULQ8.
    SMRi Q4ULQ8. Positions 2-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0664.

    Proteomic databases

    PRIDEi Q4ULQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61515 ; AAY61515 ; RF_0664 .
    GeneIDi 3401289.
    KEGGi rfe:RF_0664.
    PATRICi 17891938. VBIRicFel64634_0798.

    Phylogenomic databases

    eggNOGi COG0074.
    HOGENOMi HOG000239685.
    KOi K01902.
    OMAi FEQDPQT.
    OrthoDBi EOG644ZT0.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-681-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.261. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view ]
    Pfami PF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
    PRINTSi PR01798. SCOASYNTHASE.
    SMARTi SM00881. CoA_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52210. SSF52210. 1 hit.
    TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
    PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSUCD_RICFE
    AccessioniPrimary (citable) accession number: Q4ULQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3