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Q4ULP7

- NADK_RICFE

UniProt

Q4ULP7 - NADK_RICFE

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Protein

NAD kinase

Gene
nadK, RF_0675
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor By similarity
Binding sitei49 – 491NAD By similarity
Binding sitei144 – 1441NAD By similarity
Binding sitei152 – 1521NAD; via carbonyl oxygen By similarity
Binding sitei216 – 2161NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452NAD By similarity
Nucleotide bindingi114 – 1152NAD By similarity
Nucleotide bindingi155 – 1606NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:RF_0675
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255NAD kinaseUniRule annotationPRO_0000277993Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0675.

Structurei

3D structure databases

ProteinModelPortaliQ4ULP7.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4ULP7-1 [UniParc]FASTAAdd to Basket

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MNINKIALIY NQNSKHLAII EEIKKLYNYC KIEEAEAIIV IGGDGELLHN    50
IHRYMNLNIP FYGVNLGSLG FLMNPLDTKN LLQNIHESTV SILNPLLMQA 100
EDISGQIYTA LAINEVSIFR KTNQAAKFRI DVNGIERMSE LVADGALVAT 150
PAGSSAYNLS AGGPILPLDS NMLCLTPICS FRPRRWHGAL LLSSATIKFE 200
ILNTNKRPVN ATADFQEFNN ITNVTVKSTK DKPIKLLFNK NHTLEDRIIK 250
EQFGG 255
Length:255
Mass (Da):28,383
Last modified:July 5, 2005 - v1
Checksum:iDC3DCF2E5FA62B80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61526.1.
RefSeqiWP_011271005.1. NC_007109.1.
YP_246691.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61526; AAY61526; RF_0675.
GeneIDi3401300.
KEGGirfe:RF_0675.
PATRICi17891960. VBIRicFel64634_0809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61526.1 .
RefSeqi WP_011271005.1. NC_007109.1.
YP_246691.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4ULP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0675.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61526 ; AAY61526 ; RF_0675 .
GeneIDi 3401300.
KEGGi rfe:RF_0675.
PATRICi 17891960. VBIRicFel64634_0809.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-692-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiNADK_RICFE
AccessioniPrimary (citable) accession number: Q4ULP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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