Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4ULN0 (LON_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lon protease

EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Ordered Locus Names:RF_0692
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length778 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity. HAMAP-Rule MF_01973

Catalytic activity

Hydrolysis of proteins in presence of ATP. HAMAP-Rule MF_01973

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01973.

Induction

By heat shock By similarity. HAMAP-Rule MF_01973

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 778778Lon protease HAMAP-Rule MF_01973
PRO_0000280893

Regions

Domain6 – 203198Lon
Nucleotide binding356 – 3638ATP By similarity

Sites

Active site6791 By similarity
Active site7221 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4ULN0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: E0855BF70147205A

FASTA77887,027
        10         20         30         40         50         60 
MNKKSLPLMA LRDMVVFPGV IAPIFVGRQK SLQALSHTTV SEEDNSKYIL VTLQKKFDQE 

        70         80         90        100        110        120 
NPSKHELNNT AILAKIIQIV KLPNNTAKIL IEAVARVKLS NIKGNDAFEA NYEIIPDEEI 

       130        140        150        160        170        180 
FDVNNMRSLV DNAVQLFSKY AINDKKVNAE IIETINKEIS NSTNFINIIN ILASHLITSL 

       190        200        210        220        230        240 
EAKQHLLEET SPFKRITTVI STLTSNIVNS ETEQALQQRV RKQIEKTQRD YYLHEQMKAI 

       250        260        270        280        290        300 
QKELDEDKSE LADIEKKIKS LKLSKEAKEK AESELKKLRS MNQMSAESGV TRNYLETLLS 

       310        320        330        340        350        360 
LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP ILCLIGPPGV 

       370        380        390        400        410        420 
GKTSLVKSIA EGMGRKYTKF ALGGVRDEAE IRGHRKTYLG STPGKILGQL KKVKTSNPVM 

       430        440        450        460        470        480 
LLDEIDKMSS DFRGDPASAL LEVLDPEQNS HFVDHYLEVE YDLSNVIFIA TANSHDLPRA 

       490        500        510        520        530        540 
LSDRMEKIYI SGYVEEEKLQ IAKNYLVPKQ FKMHKIKKDE ITISETAILD LIRYYTKESG 

       550        560        570        580        590        600 
VRALEREIGA LTRKALKQIL ADKTVKHIAI DSSNLEEFLE AKKYNFGLAE KEDQIGSTTG 

       610        620        630        640        650        660 
LAYTEVGGEL LTIEALAFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAT NFGLKYDNYK 

       670        680        690        700        710        720 
DFDIHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVHRT VAMTGEITLR GNVLPIGGLK 

       730        740        750        760        770 
EKLLAASRGG IKTVLIPEEN VKDLKDIPPN IKESLEIISV SNIDQVLKHA LVETPINK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61543.1.
RefSeqYP_246708.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULN0.
SMRQ4ULN0. Positions 491-584, 594-775.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0692.

Protein family/group databases

MEROPSS16.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61543; AAY61543; RF_0692.
GeneID3400757.
KEGGrfe:RF_0692.
PATRIC17892004. VBIRicFel64634_0831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0466.
HOGENOMHOG000261410.
KOK01338.
OMANATGRKY.
OrthoDBEOG6XHC23.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-709-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01973. lon_bact.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10046. PTHR10046. 1 hit.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR00763. lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_RICFE
AccessionPrimary (citable) accession number: Q4ULN0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

Peptidase families

Classification of peptidase families and list of entries