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Protein

Lon protease

Gene

lon

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei679UniRule annotation1
Active sitei722UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 363ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:RF_0692
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002808931 – 778Lon proteaseAdd BLAST778

Proteomic databases

PRIDEiQ4ULN0

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0692

Structurei

3D structure databases

ProteinModelPortaliQ4ULN0
SMRiQ4ULN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 205Lon N-terminalPROSITE-ProRule annotationAdd BLAST200
Domaini592 – 773Lon proteolyticPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P Bacteria
COG0466 LUCA
HOGENOMiHOG000261410
KOiK01338
OMAiPILCLYG
OrthoDBiPOG091H00WA

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_01973 lon_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027543 Lon_bac
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ULN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKSLPLMA LRDMVVFPGV IAPIFVGRQK SLQALSHTTV SEEDNSKYIL
60 70 80 90 100
VTLQKKFDQE NPSKHELNNT AILAKIIQIV KLPNNTAKIL IEAVARVKLS
110 120 130 140 150
NIKGNDAFEA NYEIIPDEEI FDVNNMRSLV DNAVQLFSKY AINDKKVNAE
160 170 180 190 200
IIETINKEIS NSTNFINIIN ILASHLITSL EAKQHLLEET SPFKRITTVI
210 220 230 240 250
STLTSNIVNS ETEQALQQRV RKQIEKTQRD YYLHEQMKAI QKELDEDKSE
260 270 280 290 300
LADIEKKIKS LKLSKEAKEK AESELKKLRS MNQMSAESGV TRNYLETLLS
310 320 330 340 350
LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP
360 370 380 390 400
ILCLIGPPGV GKTSLVKSIA EGMGRKYTKF ALGGVRDEAE IRGHRKTYLG
410 420 430 440 450
STPGKILGQL KKVKTSNPVM LLDEIDKMSS DFRGDPASAL LEVLDPEQNS
460 470 480 490 500
HFVDHYLEVE YDLSNVIFIA TANSHDLPRA LSDRMEKIYI SGYVEEEKLQ
510 520 530 540 550
IAKNYLVPKQ FKMHKIKKDE ITISETAILD LIRYYTKESG VRALEREIGA
560 570 580 590 600
LTRKALKQIL ADKTVKHIAI DSSNLEEFLE AKKYNFGLAE KEDQIGSTTG
610 620 630 640 650
LAYTEVGGEL LTIEALAFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAT
660 670 680 690 700
NFGLKYDNYK DFDIHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVHRT
710 720 730 740 750
VAMTGEITLR GNVLPIGGLK EKLLAASRGG IKTVLIPEEN VKDLKDIPPN
760 770
IKESLEIISV SNIDQVLKHA LVETPINK
Length:778
Mass (Da):87,027
Last modified:July 5, 2005 - v1
Checksum:iE0855BF70147205A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61543.1
RefSeqiWP_011271022.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61543; AAY61543; RF_0692
KEGGirfe:RF_0692

Similar proteinsi

Entry informationi

Entry nameiLON_RICFE
AccessioniPrimary (citable) accession number: Q4ULN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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