Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4ULJ8 (TLCD_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 4
Alternative name(s):
ADP/ATP translocase 4
Gene names
Name:tlcD
Synonyms:tlc4
Ordered Locus Names:RF_0724
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511ADP,ATP carrier protein 4
PRO_0000286476

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane296 – 31621Helical; Potential
Transmembrane330 – 35021Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane390 – 41021Helical; Potential
Transmembrane453 – 47321Helical; Potential
Transmembrane476 – 49621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4ULJ8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: B64A98B2F1F04533

FASTA51157,870
        10         20         30         40         50         60 
MTINSSNIEN PPSKINSRFS KLTDYIWPIK RHEVSKFLFI TLLMFCILFI QNLIRALKDS 

        70         80         90        100        110        120 
IVTTMIGAET ISFLKFWGVM PSAFLMTAIY VKLVNRMKAE NIFYLIISIF LAFFALFAYV 

       130        140        150        160        170        180 
IFPNHEILHL SPVTVQNLTA NLLNLKWFIL LLSKWSFSLF YIIAELWPNV VFALLFWQFV 

       190        200        210        220        230        240 
NNITTVEESK RFYPLFGLLS QTGIYLAGQF LENLSNINDY VTNKFALQSS FHTLSIQIIL 

       250        260        270        280        290        300 
TIVLILGIIA IKTFWLLNHK VLDKEHMALL KFKAKKKSMT IAESFQMILS SRHIRLIATL 

       310        320        330        340        350        360 
LICYGIAINL VEGPWKAAAT KIYKTPTEYA AFIGSYLSYT GVFTILFVVL GSNIVRRLGW 

       370        380        390        400        410        420 
FTAAVITPLI VFITGILFFA VNNFEGFAGL IIANFILTDP ALIAITIGAI QNVLSKSSKY 

       430        440        450        460        470        480 
TLFDSTKEMA YVPLDPEIKI KGKAAADVIG TKLGKSGSAF LQSLVFIILP SASYQSISIC 

       490        500        510 
LMIIFIITCL TWLWATKELN KEYKNSIKFS Q 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61575.1.
RefSeqYP_246740.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0724.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61575; AAY61575; RF_0724.
GeneID3401098.
KEGGrfe:RF_0724.
PATRIC17892090. VBIRicFel64634_0873.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
KOK03301.
OMAFLMTAIY.
OrthoDBEOG6BCSND.
ProtClustDBCLSK870724.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-742-MONOMER.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCD_RICFE
AccessionPrimary (citable) accession number: Q4ULJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names