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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-781-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
Gene namesi
Name:prfAUniRule annotation
Ordered Locus Names:RF_0762
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Peptide chain release factor 1PRO_0000263340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N5-methylglutamineUniRule annotation

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0762.

Structurei

3D structure databases

ProteinModelPortaliQ4ULG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0216.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSDNLAKI LDKYENLGKK LSSGIMGDEF VKASKEYAEL EDVVAKIKEY
60 70 80 90 100
NKAKSELEEA NNFKLEVGLD NATLEMIEDE IHTLENSLPK LERAVKIALL
110 120 130 140 150
PKDDADSKSA IIEVRAGSGG EEAALFAAVL FNMYQRYAEL KGWRFEILAI
160 170 180 190 200
SDTGIGGYKE ASASIKGKDV FSKLKFESGV HRVQRVPETE SQGRIHTSAA
210 220 230 240 250
TVAVLPEAEE VDIKIEDKDL RIDTYRASGA GGQHVNTTDS AVRITHIPTG
260 270 280 290 300
ITVALQDEKS QHKNKAKALK ILRARIYEEE RRKKEQERAD SRRGQVGSGD
310 320 330 340 350
RSERIRTYNF PQGRVSDHRI NLTLYKIDEV VKNGQLDEFV EALIADDEAK

KLSEI
Length:355
Mass (Da):39,658
Last modified:July 5, 2005 - v1
Checksum:iD71DD1AB9CE903A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61613.1.
RefSeqiWP_011271091.1. NC_007109.1.
YP_246778.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61613; AAY61613; RF_0762.
KEGGirfe:RF_0762.
PATRICi17892184. VBIRicFel64634_0920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61613.1.
RefSeqiWP_011271091.1. NC_007109.1.
YP_246778.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4ULG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61613; AAY61613; RF_0762.
KEGGirfe:RF_0762.
PATRICi17892184. VBIRicFel64634_0920.

Phylogenomic databases

eggNOGiCOG0216.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-781-MONOMER.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiRF1_RICFE
AccessioniPrimary (citable) accession number: Q4ULG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.