Q4ULG0 (RF1_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide chain release factor 1
Short name=RF-1

Gene names

Name:	prfA
Ordered Locus Names:	RF_0762

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity. HAMAP-Rule MF_00093
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity. HAMAP-Rule MF_00093
Sequence similarities	Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
PTM	Methylation
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation release factor activity, codon specific Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Peptide chain release factor 1 HAMAP-Rule MF_00093		PRO_0000263340
Amino acid modifications
	Modified residue	233	1	N5-methylglutamine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4ULG0 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: D71DD1AB9CE903A1	FASTA	355	39,658
	10 20 30 40 50 60 MSFSDNLAKI LDKYENLGKK LSSGIMGDEF VKASKEYAEL EDVVAKIKEY NKAKSELEEA 70 80 90 100 110 120 NNFKLEVGLD NATLEMIEDE IHTLENSLPK LERAVKIALL PKDDADSKSA IIEVRAGSGG 130 140 150 160 170 180 EEAALFAAVL FNMYQRYAEL KGWRFEILAI SDTGIGGYKE ASASIKGKDV FSKLKFESGV 190 200 210 220 230 240 HRVQRVPETE SQGRIHTSAA TVAVLPEAEE VDIKIEDKDL RIDTYRASGA GGQHVNTTDS 250 260 270 280 290 300 AVRITHIPTG ITVALQDEKS QHKNKAKALK ILRARIYEEE RRKKEQERAD SRRGQVGSGD 310 320 330 340 350 RSERIRTYNF PQGRVSDHRI NLTLYKIDEV VKNGQLDEFV EALIADDEAK KLSEI

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61613.1.
RefSeq	YP_246778.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 2B3T based on UniProtKB P0A7I0.
ProteinModelPortal	Q4ULG0.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0762.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61613; AAY61613; RF_0762.
GeneID	3400829.
KEGG	rfe:RF_0762.
PATRIC	17892184. VBIRicFel64634_0920.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0216.
HOGENOM	HOG000074815.
KO	K02835.
OMA	SVMLEIR.
ProtClustDB	PRK00591.
Family and domain databases
Gene3D	3.30.160.20. 1 hit.
HAMAP	MF_00093. Rel_fac_1.
InterPro	IPR014720. dsRNA-bd-like_dom. IPR005139. PCRF. IPR000352. Pep_chain_release_fac_I_II. IPR004373. PrfA. [Graphical view]
Pfam	PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit. [Graphical view]
SMART	SM00937. PCRF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00019. prfA. 1 hit.
PROSITE	PS00745. RF_PROK_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RF1_RICFE

Accession

Primary (citable) accession number: Q4ULG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program