Q4ULF7 (RHO_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription termination factor Rho
EC=3.6.4.-

Alternative name(s):
ATP-dependent helicase Rho

Gene names

Name:	rho
Ordered Locus Names:	RF_0765

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity. HAMAP-Rule MF_01884
Subunit structure	Homohexamer. The homohexamer assembles into an open ring structure By similarity.
Sequence similarities	Belongs to the Rho family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Transcription termination
Ligand	ATP-binding Nucleotide-binding RNA-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, termination Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP RNA binding Inferred from electronic annotation. Source: HAMAP RNA-dependent ATPase activity Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Transcription termination factor Rho HAMAP-Rule MF_01884		PRO_0000286652
Regions
	Nucleotide binding	201 – 206	6	ATP Potential
	Nucleotide binding	213 – 218	6	ATP By similarity
Sites
	Binding site	244	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4ULF7 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 840CAC28B46115A7	FASTA	458	51,269
	10 20 30 40 50 60 MNTTNKESTE ELNNTESNNN HNNFAENGNI INLKQLKRKL PEELQAQAEE LKIENINSLL 70 80 90 100 110 120 KQELVFAILK KSVEQGGLIV GEGVLEVLPD GFGFLRSPEV NYLAGPDDIY ISPSQIRRFG 130 140 150 160 170 180 LRTGDTVEGQ IRAPKAGERY FALLKVNRVN FEDPSKAYHR VHFDNLTPLY PDEKLGLELE 190 200 210 220 230 240 NNSKDSKDFS TRVIELVAPM GKGQRALIVA PPRTGKTVLL QNIAHAITTN NPEVFLIVLL 250 260 270 280 290 300 IDERPEEVTD MQRSVRGEVV SSTFDEPASR HVQLAEMVIE KAKRLVEHKK DVVILVDAIT 310 320 330 340 350 360 RLARAYNTVV PSSGKVLTGG VDANALQRPK RFFGAARNIE NGGSLTIIGT ALIETGSRMD 370 380 390 400 410 420 EVIFEEFKGT GNSEIVLDRK IADKRIYPAI DITRSGTRKE DLLVDKIILN KMWVLRRIID 430 440 450 PMGSSEAIEF LLKKLENTKT NGEFFEMMKS PERPKNGL

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61616.1.
RefSeq	YP_246781.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4ULF7.
SMR	Q4ULF7. Positions 31-449.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0765.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61616; AAY61616; RF_0765.
GeneID	3401644.
KEGG	rfe:RF_0765.
PATRIC	17892192. VBIRicFel64634_0924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1158.
HOGENOM	HOG000076952.
KO	K03628.
OMA	FGFLRAP.
ProtClustDB	PRK09376.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_01884. Rho.
InterPro	IPR003593. AAA+_ATPase. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR011129. Cold_shock_prot. IPR012340. NA-bd_OB-fold. IPR011112. Rho_N. IPR011113. Rho_RNA-bd. IPR004665. Term_rho. [Graphical view]
Pfam	PF00006. ATP-synt_ab. 1 hit. PF07498. Rho_N. 1 hit. PF07497. Rho_RNA_bind. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00357. CSP. 1 hit. SM00959. Rho_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF68912. Rho_N. 1 hit.
TIGRFAMs	TIGR00767. rho. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RHO_RICFE

Accession

Primary (citable) accession number: Q4ULF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program