Q4ULD7 (IDI2_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	RF_0785

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP-Rule MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP-Rule MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation-reduction process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Isopentenyl-diphosphate delta-isomerase HAMAP-Rule MF_00354		PRO_0000229508

Sequences

	Sequence		Length	Mass (Da)
	Q4ULD7 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 48701A8380132B3D	FASTA	345	37,330
	10 20 30 40 50 60 MSKMPKNQNL DIERKQDHIE INLMKNVAST LTSGFESMQF IHNALPEINY DSIDTTSTFL 70 80 90 100 110 120 GKSLQAPILI SSMTGGTTRA GDINYRLAQA AQKAGIAMGL GSMRVLLTKP DTITTFAVRD 130 140 150 160 170 180 VAPDIPLLAN IGAVQLNYFV TPKECQYLVD VVKADALILH LNVLQELTQP EGNRNWENLL 190 200 210 220 230 240 PKIKELVNYL SVPVIVKEVG YGLSKKVAES LIGVGVKVLD IAGSGGTSWS QVEAYRATNS 250 260 270 280 290 300 LQNRIASSFI NWGIPTLDSL KMVREVSGDI PIIASGGLKS GIDGAKAIRM GANIFGLAGQ 310 320 330 340 FLKAADTSES LLSEEVQLII EQLKITMLCT GSRTLKDLAK AEIRL

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61636.1.
RefSeq	YP_246801.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4ULD7.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0785.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61636; AAY61636; RF_0785.
GeneID	3401666.
KEGG	rfe:RF_0785.
PATRIC	17892242. VBIRicFel64634_0947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1304.
HOGENOM	HOG000072126.
KO	K01823.
OMA	FEFPFYI.
ProtClustDB	PRK05437.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00354. Idi_2.
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
PANTHER	PTHR10578:SF3. PTHR10578:SF3. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_RICFE

Accession

Primary (citable) accession number: Q4ULD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program