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Q4UL68

- NUON_RICFE

UniProt

Q4UL68 - NUON_RICFE

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-879-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:RF_0854
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458NADH-quinone oxidoreductase subunit NPRO_0000272332Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0854.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei30 – 5021HelicalUniRule annotationAdd
    BLAST
    Transmembranei62 – 8221HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei118 – 13821HelicalUniRule annotationAdd
    BLAST
    Transmembranei153 – 17321HelicalUniRule annotationAdd
    BLAST
    Transmembranei194 – 21421HelicalUniRule annotationAdd
    BLAST
    Transmembranei235 – 25521HelicalUniRule annotationAdd
    BLAST
    Transmembranei261 – 28121HelicalUniRule annotationAdd
    BLAST
    Transmembranei290 – 31021HelicalUniRule annotationAdd
    BLAST
    Transmembranei318 – 33821HelicalUniRule annotationAdd
    BLAST
    Transmembranei361 – 38121HelicalUniRule annotationAdd
    BLAST
    Transmembranei397 – 41721HelicalUniRule annotationAdd
    BLAST
    Transmembranei438 – 45821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000010703.
    KOiK00343.
    OMAiIEAQLYG.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UL68-1 [UniParc]FASTAAdd to Basket

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    MLLLLPEITL TLIALLGQFF AVIIPNKNRI ISNIIILLCI LSIFLTFKYS    50
    SYEGVWYSFA TGINIGISKS IVLLFTIISM IIYRDYSILI AEELKFEFIT 100
    LILLSVVGIF VAISSRNFLL LFCGMELTAL TSYALAGFKL NDIKSSEGAL 150
    KYFILGSLVS CLSLFGISFI YGFGGSLQFE DILYKLNNNS GMNLGLIIGI 200
    VLFLSSIFFK LSSVPLHFWV PDVYEGSPIS SVTYFTAASK IGMVIVLLNI 250
    SKLIIGNYYP INYNLIKIIA ILSMLFGAFG AIRQTSLKRL MAYSTILNIG 300
    YVLIGVLLHN QEGYKAALLY ILIYAVGSIG FFTCLIMLLG KDADKASFKT 350
    IQGIAENHKT IAAIISIVMF SMIGIPPLTG FFGKYYLFYQ AINQEEFILA 400
    YCGIFTSVVA AFYYLKVVKA MYFSKKIEII KLPMLYGLLL INYLVVGFLL 450
    LGSFIISF 458
    Length:458
    Mass (Da):50,958
    Last modified:July 5, 2005 - v1
    Checksum:i3AE198F230511F0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61705.1.
    RefSeqiYP_246870.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61705; AAY61705; RF_0854.
    GeneIDi3400730.
    KEGGirfe:RF_0854.
    PATRICi17892409. VBIRicFel64634_1026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61705.1 .
    RefSeqi YP_246870.1. NC_007109.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61705 ; AAY61705 ; RF_0854 .
    GeneIDi 3400730.
    KEGGi rfe:RF_0854.
    PATRICi 17892409. VBIRicFel64634_1026.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000010703.
    KOi K00343.
    OMAi IEAQLYG.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-879-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiNUON_RICFE
    AccessioniPrimary (citable) accession number: Q4UL68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3