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Q4UL62 (DNAB_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Replicative DNA helicase
EC=3.6.4.12
Gene names
Name:dnaB
Ordered Locus Names:RF_0860
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the helicase family. DnaB subfamily.

Contains 1 SF4 helicase domain.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentPrimosome
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA duplex unwinding

Inferred from electronic annotation. Source: GOC

DNA replication, synthesis of RNA primer

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentreplisome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA helicase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Replicative DNA helicase
PRO_0000281067

Regions

Domain198 – 490293SF4 helicase
Nucleotide binding229 – 2368ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UL62 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: E7B7AC134C73C992

FASTA49455,840
        10         20         30         40         50         60 
MARNKINNDK NIAANEEADI PIPRVLPSNV QAEQMLLGAI LTNNELLSYV SEFLRSEHFF 

        70         80         90        100        110        120 
EPIHQKIYNA IEKITEKGLI ATPITLRSML TQDELFQEIE GAEYLAKLIT MSMMVINPVD 

       130        140        150        160        170        180 
YGKIIYDLAI KRNLINIGEE VVNDAYNSSL EIEAREQIEH AEAKLYDLAS ESLNEKSFTR 

       190        200        210        220        230        240 
IGIPISESLA SINRAMKNND HVIGISTGLL DLDNKLFGFH NSDLLILAGR PSMGKTAFAI 

       250        260        270        280        290        300 
NLALNACNNM RLKNIRDNQE IQSVGFFSLE MSSEQLTTRL LSMCAEIDST SLRTGILGEE 

       310        320        330        340        350        360 
KYNRLRKEAN TLSELQFFID DTPALSISAI RTRARRMKRK HNLGILFIDY LQLIRGVSKS 

       370        380        390        400        410        420 
ENRVSEISEI TQGLKAIAKE LNIPVIALSQ LSRAVELRED KKPMLSDLRE SGTIEQDADI 

       430        440        450        460        470        480 
VMFIYREEYY LTRKEPAAGD AKHAEWLDKL NKVYNIADII VAKHRNGPVG NVPLYYDSQF 

       490 
SKFGNLEKRT FSSN

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000053 Genomic DNA. Translation: AAY61711.1.
RefSeqYP_246876.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UL62.
ModBaseSearch...

Protein-protein interaction databases

STRING315456.RF_0860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61711; AAY61711; RF_0860.
GeneID3400736.
KEGGrfe:RF_0860.
PATRIC17892425. VBIRicFel64634_1034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0305.
HOGENOMHOG000113195.
KOK02314.
OMAYRTALML.
ProtClustDBPRK09165.

Family and domain databases

Gene3D1.10.860.10. 1 hit.
InterProIPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
[Graphical view]
PfamPF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
[Graphical view]
SUPFAMSSF48024. DNA_helicase_DnaB-like_N. 1 hit.
TIGRFAMsTIGR00665. DnaB. 1 hit.
PROSITEPS51199. SF4_HELICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAB_RICFE
AccessionPrimary (citable) accession number: Q4UL62
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

SIMILARITY comments

Index of protein domains and families

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