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Q4UL32 (FAD3_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative fatty acid oxidation complex trifunctional enzyme

Including the following 2 domains:

  1. 3-hydroxyacyl-CoA dehydrogenase
    EC=1.1.1.35
  2. Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase
    EC=4.2.1.17
    EC=5.3.3.8
Gene names
Ordered Locus Names:RF_0890
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

Sequence similarities

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 720720Putative fatty acid oxidation complex trifunctional enzyme
PRO_0000285697

Regions

Region1 – 3843843-hydroxyacyl-CoA dehydrogenase
Region453 – 720268Enoyl-CoA hydratase/isomerase

Sequences

Sequence LengthMass (Da)Tools
Q4UL32 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: AB2E8CBC1C1F1426

FASTA72081,043
        10         20         30         40         50         60 
MQNEIKKVCV IGSGVMGSGI AALIANSSHK VVLLDIIAKD SDDPNKIVKT AKENLHKQKP 

        70         80         90        100        110        120 
PPLSFPDKVN FITIGNLEHD LELIRDCDLV IEVIVEKLEI KHQLYNKIIP YLKEDAIIAS 

       130        140        150        160        170        180 
NTSTLPLKRL KENLPDNIKS RFVITHFFNP PRYMELLELI IDSMVKFEVI ERVSGFLTKT 

       190        200        210        220        230        240 
LGKTIVKCND TPGFIANRVG CFLLELVARK AISQKLDFVA LDKIFTICLG LPSTGIFGLY 

       250        260        270        280        290        300 
DLIGHDVMKL ISSSLLAALP ANDAYHKIYV NTPVLDKMIE KKLIGRKGEG GFYRLSVSNG 

       310        320        330        340        350        360 
KKIKEVININ DLSYSSVQKV DISFNNLDEL LVSDSVYGKI FTEIITEFYV YLASLVPSVT 

       370        380        390        400        410        420 
DNIYDIDAAM KLGYSWKYGP FELLTIAAKD GWNSVIKNAD LMHIPLPQYL GNKEYQKIDK 

       430        440        450        460        470        480 
QKFNSHKDIL QESQIVLEND SAKLINYREN FIFVITTKMN CLNHNVFYLL QEAASKAEKD 

       490        500        510        520        530        540 
GKNLYIYPQG NNFSAGADLK LLLSYIEDGN FHDLENLLKL GQQTMLHLKY SGVHIISCAK 

       550        560        570        580        590        600 
GVALGGGCEL LLYSSYIVAN QELNAGLVEL GVGLIPGWGG VTEMFVRSKG DKTKLIRNVR 

       610        620        630        640        650        660 
NIIEQNKTSS ADYFKSDYDV ESMHVNMNKH YILDEALKLN LSKKIVPIPH KITLPKINLA 

       670        680        690        700        710        720 
TEIDTSKYND LQNKVLSKFQ NIIDKHPDTN EEELLGYERE IFLELAKDPK TIEKLKAIVK 

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61741.1.
RefSeqYP_246906.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UL32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61741; AAY61741; RF_0890.
GeneID3401556.
KEGGrfe:RF_0890.
PATRIC17892493. VBIRicFel64634_1068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1250.
HOGENOMHOG000264370.
KOK01782.
OMAYDYEDGE.
OrthoDBEOG6B8XF5.
ProtClustDBCLSK870987.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-915-MONOMER.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFAD3_RICFE
AccessionPrimary (citable) accession number: Q4UL32
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names