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Q4UL32

- FAD3_RICFE

UniProt

Q4UL32 - FAD3_RICFE

Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RF_0890

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
    (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. coenzyme binding Source: InterPro
    3. dodecenoyl-CoA delta-isomerase activity Source: UniProtKB-EC
    4. enoyl-CoA hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Lyase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-915-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative fatty acid oxidation complex trifunctional enzyme
    Including the following 2 domains:
    3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
    Gene namesi
    Ordered Locus Names:RF_0890
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285697Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UL32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
    BLAST
    Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
    In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG1250.
    HOGENOMiHOG000264370.
    KOiK01782.
    OMAiKGPLEFA.
    OrthoDBiEOG6B8XF5.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q4UL32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNEIKKVCV IGSGVMGSGI AALIANSSHK VVLLDIIAKD SDDPNKIVKT    50
    AKENLHKQKP PPLSFPDKVN FITIGNLEHD LELIRDCDLV IEVIVEKLEI 100
    KHQLYNKIIP YLKEDAIIAS NTSTLPLKRL KENLPDNIKS RFVITHFFNP 150
    PRYMELLELI IDSMVKFEVI ERVSGFLTKT LGKTIVKCND TPGFIANRVG 200
    CFLLELVARK AISQKLDFVA LDKIFTICLG LPSTGIFGLY DLIGHDVMKL 250
    ISSSLLAALP ANDAYHKIYV NTPVLDKMIE KKLIGRKGEG GFYRLSVSNG 300
    KKIKEVININ DLSYSSVQKV DISFNNLDEL LVSDSVYGKI FTEIITEFYV 350
    YLASLVPSVT DNIYDIDAAM KLGYSWKYGP FELLTIAAKD GWNSVIKNAD 400
    LMHIPLPQYL GNKEYQKIDK QKFNSHKDIL QESQIVLEND SAKLINYREN 450
    FIFVITTKMN CLNHNVFYLL QEAASKAEKD GKNLYIYPQG NNFSAGADLK 500
    LLLSYIEDGN FHDLENLLKL GQQTMLHLKY SGVHIISCAK GVALGGGCEL 550
    LLYSSYIVAN QELNAGLVEL GVGLIPGWGG VTEMFVRSKG DKTKLIRNVR 600
    NIIEQNKTSS ADYFKSDYDV ESMHVNMNKH YILDEALKLN LSKKIVPIPH 650
    KITLPKINLA TEIDTSKYND LQNKVLSKFQ NIIDKHPDTN EEELLGYERE 700
    IFLELAKDPK TIEKLKAIVK 720
    Length:720
    Mass (Da):81,043
    Last modified:July 5, 2005 - v1
    Checksum:iAB2E8CBC1C1F1426
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61741.1.
    RefSeqiWP_011271216.1. NC_007109.1.
    YP_246906.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61741; AAY61741; RF_0890.
    GeneIDi3401556.
    KEGGirfe:RF_0890.
    PATRICi17892493. VBIRicFel64634_1068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61741.1 .
    RefSeqi WP_011271216.1. NC_007109.1.
    YP_246906.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UL32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61741 ; AAY61741 ; RF_0890 .
    GeneIDi 3401556.
    KEGGi rfe:RF_0890.
    PATRICi 17892493. VBIRicFel64634_1068.

    Phylogenomic databases

    eggNOGi COG1250.
    HOGENOMi HOG000264370.
    KOi K01782.
    OMAi KGPLEFA.
    OrthoDBi EOG6B8XF5.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-915-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiFAD3_RICFE
    AccessioniPrimary (citable) accession number: Q4UL32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3