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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RF_0890

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RF_0890
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856971 – 720Putative fatty acid oxidation complex trifunctional enzymeAdd BLAST720

Proteomic databases

PRIDEiQ4UL32

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0890

Structurei

3D structure databases

ProteinModelPortaliQ4UL32
SMRiQ4UL32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 3843-hydroxyacyl-CoA dehydrogenaseAdd BLAST384
Regioni453 – 720Enoyl-CoA hydratase/isomeraseAdd BLAST268

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105DYT Bacteria
COG1024 LUCA
COG1250 LUCA
HOGENOMiHOG000264370
KOiK01782
OMAiGQGFYKK
OrthoDBiPOG091H0NDD

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR029045 ClpP/crotonase-like_dom_sf
IPR032259 HIBYL-CoA-H
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF16113 ECH_2, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 2 hits

Sequencei

Sequence statusi: Complete.

Q4UL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGSGVMGSGI AALIANSSHK VVLLDIIAKD SDDPNKIVKT
60 70 80 90 100
AKENLHKQKP PPLSFPDKVN FITIGNLEHD LELIRDCDLV IEVIVEKLEI
110 120 130 140 150
KHQLYNKIIP YLKEDAIIAS NTSTLPLKRL KENLPDNIKS RFVITHFFNP
160 170 180 190 200
PRYMELLELI IDSMVKFEVI ERVSGFLTKT LGKTIVKCND TPGFIANRVG
210 220 230 240 250
CFLLELVARK AISQKLDFVA LDKIFTICLG LPSTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLLAALP ANDAYHKIYV NTPVLDKMIE KKLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVININ DLSYSSVQKV DISFNNLDEL LVSDSVYGKI FTEIITEFYV
360 370 380 390 400
YLASLVPSVT DNIYDIDAAM KLGYSWKYGP FELLTIAAKD GWNSVIKNAD
410 420 430 440 450
LMHIPLPQYL GNKEYQKIDK QKFNSHKDIL QESQIVLEND SAKLINYREN
460 470 480 490 500
FIFVITTKMN CLNHNVFYLL QEAASKAEKD GKNLYIYPQG NNFSAGADLK
510 520 530 540 550
LLLSYIEDGN FHDLENLLKL GQQTMLHLKY SGVHIISCAK GVALGGGCEL
560 570 580 590 600
LLYSSYIVAN QELNAGLVEL GVGLIPGWGG VTEMFVRSKG DKTKLIRNVR
610 620 630 640 650
NIIEQNKTSS ADYFKSDYDV ESMHVNMNKH YILDEALKLN LSKKIVPIPH
660 670 680 690 700
KITLPKINLA TEIDTSKYND LQNKVLSKFQ NIIDKHPDTN EEELLGYERE
710 720
IFLELAKDPK TIEKLKAIVK
Length:720
Mass (Da):81,043
Last modified:July 5, 2005 - v1
Checksum:iAB2E8CBC1C1F1426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61741.1
RefSeqiWP_011271216.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61741; AAY61741; RF_0890
KEGGirfe:RF_0890

Similar proteinsi

Entry informationi

Entry nameiFAD3_RICFE
AccessioniPrimary (citable) accession number: Q4UL32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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