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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RF_0890

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-915-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RF_0890
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0890.

Structurei

3D structure databases

ProteinModelPortaliQ4UL32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
BLAST
Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiPMGPYEL.
OrthoDBiEOG6B8XF5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4UL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGSGVMGSGI AALIANSSHK VVLLDIIAKD SDDPNKIVKT
60 70 80 90 100
AKENLHKQKP PPLSFPDKVN FITIGNLEHD LELIRDCDLV IEVIVEKLEI
110 120 130 140 150
KHQLYNKIIP YLKEDAIIAS NTSTLPLKRL KENLPDNIKS RFVITHFFNP
160 170 180 190 200
PRYMELLELI IDSMVKFEVI ERVSGFLTKT LGKTIVKCND TPGFIANRVG
210 220 230 240 250
CFLLELVARK AISQKLDFVA LDKIFTICLG LPSTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLLAALP ANDAYHKIYV NTPVLDKMIE KKLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVININ DLSYSSVQKV DISFNNLDEL LVSDSVYGKI FTEIITEFYV
360 370 380 390 400
YLASLVPSVT DNIYDIDAAM KLGYSWKYGP FELLTIAAKD GWNSVIKNAD
410 420 430 440 450
LMHIPLPQYL GNKEYQKIDK QKFNSHKDIL QESQIVLEND SAKLINYREN
460 470 480 490 500
FIFVITTKMN CLNHNVFYLL QEAASKAEKD GKNLYIYPQG NNFSAGADLK
510 520 530 540 550
LLLSYIEDGN FHDLENLLKL GQQTMLHLKY SGVHIISCAK GVALGGGCEL
560 570 580 590 600
LLYSSYIVAN QELNAGLVEL GVGLIPGWGG VTEMFVRSKG DKTKLIRNVR
610 620 630 640 650
NIIEQNKTSS ADYFKSDYDV ESMHVNMNKH YILDEALKLN LSKKIVPIPH
660 670 680 690 700
KITLPKINLA TEIDTSKYND LQNKVLSKFQ NIIDKHPDTN EEELLGYERE
710 720
IFLELAKDPK TIEKLKAIVK
Length:720
Mass (Da):81,043
Last modified:July 5, 2005 - v1
Checksum:iAB2E8CBC1C1F1426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61741.1.
RefSeqiWP_011271216.1. NC_007109.1.
YP_246906.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61741; AAY61741; RF_0890.
KEGGirfe:RF_0890.
PATRICi17892493. VBIRicFel64634_1068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61741.1.
RefSeqiWP_011271216.1. NC_007109.1.
YP_246906.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UL32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61741; AAY61741; RF_0890.
KEGGirfe:RF_0890.
PATRICi17892493. VBIRicFel64634_1068.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiPMGPYEL.
OrthoDBiEOG6B8XF5.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-915-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiFAD3_RICFE
AccessioniPrimary (citable) accession number: Q4UL32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.