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Q4UL10 (UVRC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:RF_0912
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642UvrABC system protein C HAMAP-Rule MF_00203
PRO_0000227469

Regions

Domain20 – 9778GIY-YIG
Domain207 – 24236UVR

Sequences

Sequence LengthMass (Da)Tools
Q4UL10 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 481B428CC1FD9012

FASTA64273,315
        10         20         30         40         50         60 
MTLEITGSEL IKSKLIDAPE RCGVYRMFDV NKQVIYVGKA KNLKKRLTNY IKSDLDNKTL 

        70         80         90        100        110        120 
RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DDKSFPFIKL RLDHDFPQLL 

       130        140        150        160        170        180 
KYRGKTLNSG KFFGPFASST EVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA 

       190        200        210        220        230        240 
PCVGKINKED YRDLVAQVKD FLQGRTKELQ ENLSKKMEEL SSQMRFEEAA EIRDRIKALS 

       250        260        270        280        290        300 
YVQLKAGVSD IVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTST ENSTKEEVLE 

       310        320        330        340        350        360 
YFLLQFYQKQ QVPAEIIINH EINDKENVIE AIKKINNITK LNIIIPISGG KAKLVQNAAI 

       370        380        390        400        410        420 
NALFSLEQYL KKFAKNQEIM LEIKELFGLS EISERIEIYD NSHIQGKFAV GVMVVAGKAG 

       430        440        450        460        470        480 
FDKKEYRVFS LSSRNSSLSS HASPLSSRNL IAGSSSYFLD PVVKPRDDIV GDDYEMLRQV 

       490        500        510        520        530        540 
LTRRLTRLKN EPHKLPSLMI IDGGRGHLGV VKEVMDKFEM NIPFVCMSKG VDRNAGLEQF 

       550        560        570        580        590        600 
HMTGKEVFTL DKNLPIMKYL QILRDEAHNF AIKNHRLGRS RAIKLSSLDD IEGIGETRKK 

       610        620        630        640 
ALLHYFGSYK AVCDATIDEL TKVNGINKSL AEMIFRTLHK SL 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61763.1.
RefSeqYP_246928.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UL10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0912.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61763; AAY61763; RF_0912.
GeneID3401578.
KEGGrfe:RF_0912.
PATRIC17892549. VBIRicFel64634_1096.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.
ProtClustDBPRK00558.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-937-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR022439. RPE4.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR03777. RPE4. 1 hit.
TIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_RICFE
AccessionPrimary (citable) accession number: Q4UL10
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names