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Q4UKY1 (SECA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein translocase subunit SecA
Gene names
Name:secA
Ordered Locus Names:RF_0941
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382

Cofactor

May bind 1 zinc ion per subunit Potential.

Subunit structure

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity. HAMAP-Rule MF_01382

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382

Sequence similarities

Belongs to the SecA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 906906Protein translocase subunit SecA HAMAP-Rule MF_01382
PRO_0000277301

Regions

Nucleotide binding101 – 1088ATP Potential

Sites

Metal binding8901Zinc Potential
Metal binding8921Zinc Potential
Metal binding9011Zinc Potential
Metal binding9021Zinc Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UKY1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: C3229F5E6BBE415F

FASTA906103,324
        10         20         30         40         50         60 
MLSILKKLFG TANDRTVKKL FSEITKINSL EPAIQKLSDE ELKNKTVEFK EKLKNGATLD 

        70         80         90        100        110        120 
DIVYEAFAVV REAARRVCGM RHFDVQLIGG LILHRGMITE MRTGEGKTLV ATLPAYLNAL 

       130        140        150        160        170        180 
TGKGVHVVTV NDYLASRDSA SMGKIYNFLG LSVGCIVAGM PDEAKRAAYN ADITHATNNE 

       190        200        210        220        230        240 
LGFDYLRDNM KYSLQERVLR PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKIDK 

       250        260        270        280        290        300 
IVRMLNTSDF EKDEKLKTIN LTETGITHIE SLLSKEHLIK PDTGLYDFEN LTLVHYVNQA 

       310        320        330        340        350        360 
LRAHNMFTVD VDYLVREGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV KIQNENQTLA 

       370        380        390        400        410        420 
SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP THNKVTRLDL DDEIYGSKKE 

       430        440        450        460        470        480 
KYDAILKLIK DCYDRGQPIL VGTISIEKSE ELSSVLNKEK IPHKVLNAKF HEQEAFIIAQ 

       490        500        510        520        530        540 
AGRFKAVTIA TNMAGRGTDI MLGGNPEMLI EQLDEDHNYE TKAAEIKAQI SEEKKQVIEA 

       550        560        570        580        590        600 
GGLFVIGTER HESRRIDNQL RGRSGRQGDP GKTKFFLSLD DDLMRIFASD RISGVLRTLG 

       610        620        630        640        650        660 
LKDGEAIHHP MISRSLEKAQ QKVEGHNYEM RKNLLRFDDV MNDQRKIIYE QRTEIIKSKD 

       670        680        690        700        710        720 
SHGFLNSTTE ELAKKIVLTF MPVGSYREDW DIENLSVELH RVFSMKFDHN LVSKNDVTEE 

       730        740        750        760        770        780 
EITKIVIQTA HDIYKSKEEA YSSELMHNAV KYILLTTLDQ VWKDHLYSLD HLRQGISLRA 

       790        800        810        820        830        840 
YAQKDPLSEY KREAFNLFEQ MLNNLKELFI QTVYHFHIDL KHIQKEDVSL EHKKLQKNMR 

       850        860        870        880        890        900 
ESREDPAFSK YNAGSSLETD LKPVVSRVDP KDRNPDDPTS WGRVSRNELC PCGSGKKYKY 


CHGANE 

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61792.1.
RefSeqYP_246957.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKY1.
SMRQ4UKY1. Positions 13-231.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61792; AAY61792; RF_0941.
GeneID3400947.
KEGGrfe:RF_0941.
PATRIC17892621. VBIRicFel64634_1130.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0653.
HOGENOMHOG000218168.
KOK03070.
OMAEAYEFQQ.
OrthoDBEOG654P48.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-968-MONOMER.

Family and domain databases

Gene3D1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPMF_01382. SecA.
InterProIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSPR00906. SECA.
SMARTSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsTIGR00963. secA. 1 hit.
PROSITEPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSECA_RICFE
AccessionPrimary (citable) accession number: Q4UKY1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names