Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UKY1

- SECA_RICFE

UniProt

Q4UKY1 - SECA_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi890 – 8901ZincUniRule annotation
Metal bindingi892 – 8921ZincUniRule annotation
Metal bindingi901 – 9011ZincUniRule annotation
Metal bindingi902 – 9021ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:RF_0941
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Protein translocase subunit SecAPRO_0000277301Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0941.

Structurei

3D structure databases

ProteinModelPortaliQ4UKY1.
SMRiQ4UKY1. Positions 13-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiEAYEFQQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSILKKLFG TANDRTVKKL FSEITKINSL EPAIQKLSDE ELKNKTVEFK
60 70 80 90 100
EKLKNGATLD DIVYEAFAVV REAARRVCGM RHFDVQLIGG LILHRGMITE
110 120 130 140 150
MRTGEGKTLV ATLPAYLNAL TGKGVHVVTV NDYLASRDSA SMGKIYNFLG
160 170 180 190 200
LSVGCIVAGM PDEAKRAAYN ADITHATNNE LGFDYLRDNM KYSLQERVLR
210 220 230 240 250
PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKIDK IVRMLNTSDF
260 270 280 290 300
EKDEKLKTIN LTETGITHIE SLLSKEHLIK PDTGLYDFEN LTLVHYVNQA
310 320 330 340 350
LRAHNMFTVD VDYLVREGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV
360 370 380 390 400
KIQNENQTLA SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP
410 420 430 440 450
THNKVTRLDL DDEIYGSKKE KYDAILKLIK DCYDRGQPIL VGTISIEKSE
460 470 480 490 500
ELSSVLNKEK IPHKVLNAKF HEQEAFIIAQ AGRFKAVTIA TNMAGRGTDI
510 520 530 540 550
MLGGNPEMLI EQLDEDHNYE TKAAEIKAQI SEEKKQVIEA GGLFVIGTER
560 570 580 590 600
HESRRIDNQL RGRSGRQGDP GKTKFFLSLD DDLMRIFASD RISGVLRTLG
610 620 630 640 650
LKDGEAIHHP MISRSLEKAQ QKVEGHNYEM RKNLLRFDDV MNDQRKIIYE
660 670 680 690 700
QRTEIIKSKD SHGFLNSTTE ELAKKIVLTF MPVGSYREDW DIENLSVELH
710 720 730 740 750
RVFSMKFDHN LVSKNDVTEE EITKIVIQTA HDIYKSKEEA YSSELMHNAV
760 770 780 790 800
KYILLTTLDQ VWKDHLYSLD HLRQGISLRA YAQKDPLSEY KREAFNLFEQ
810 820 830 840 850
MLNNLKELFI QTVYHFHIDL KHIQKEDVSL EHKKLQKNMR ESREDPAFSK
860 870 880 890 900
YNAGSSLETD LKPVVSRVDP KDRNPDDPTS WGRVSRNELC PCGSGKKYKY

CHGANE
Length:906
Mass (Da):103,324
Last modified:July 5, 2005 - v1
Checksum:iC3229F5E6BBE415F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61792.1.
RefSeqiYP_246957.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61792; AAY61792; RF_0941.
GeneIDi3400947.
KEGGirfe:RF_0941.
PATRICi17892621. VBIRicFel64634_1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61792.1 .
RefSeqi YP_246957.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKY1.
SMRi Q4UKY1. Positions 13-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61792 ; AAY61792 ; RF_0941 .
GeneIDi 3400947.
KEGGi rfe:RF_0941.
PATRICi 17892621. VBIRicFel64634_1130.

Phylogenomic databases

eggNOGi COG0653.
HOGENOMi HOG000218168.
KOi K03070.
OMAi EAYEFQQ.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-968-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSECA_RICFE
AccessioniPrimary (citable) accession number: Q4UKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3