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Q4UKY1

- SECA_RICFE

UniProt

Q4UKY1 - SECA_RICFE

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

    Cofactori

    May bind 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi890 – 8901ZincUniRule annotation
    Metal bindingi892 – 8921ZincUniRule annotation
    Metal bindingi901 – 9011ZincUniRule annotation
    Metal bindingi902 – 9021ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1088ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein import Source: InterPro
    3. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecAUniRule annotation
    Gene namesi
    Name:secAUniRule annotation
    Ordered Locus Names:RF_0941
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
    Note: Distribution is 50-50.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 906906Protein translocase subunit SecAPRO_0000277301Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKY1.
    SMRiQ4UKY1. Positions 13-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0653.
    HOGENOMiHOG000218168.
    KOiK03070.
    OMAiEAYEFQQ.
    OrthoDBiEOG654P48.

    Family and domain databases

    Gene3Di1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPiMF_01382. SecA.
    InterProiIPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view]
    PfamiPF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view]
    PRINTSiPR00906. SECA.
    SMARTiSM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsiTIGR00963. secA. 1 hit.
    PROSITEiPS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKY1-1 [UniParc]FASTAAdd to Basket

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    MLSILKKLFG TANDRTVKKL FSEITKINSL EPAIQKLSDE ELKNKTVEFK    50
    EKLKNGATLD DIVYEAFAVV REAARRVCGM RHFDVQLIGG LILHRGMITE 100
    MRTGEGKTLV ATLPAYLNAL TGKGVHVVTV NDYLASRDSA SMGKIYNFLG 150
    LSVGCIVAGM PDEAKRAAYN ADITHATNNE LGFDYLRDNM KYSLQERVLR 200
    PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKIDK IVRMLNTSDF 250
    EKDEKLKTIN LTETGITHIE SLLSKEHLIK PDTGLYDFEN LTLVHYVNQA 300
    LRAHNMFTVD VDYLVREGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV 350
    KIQNENQTLA SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP 400
    THNKVTRLDL DDEIYGSKKE KYDAILKLIK DCYDRGQPIL VGTISIEKSE 450
    ELSSVLNKEK IPHKVLNAKF HEQEAFIIAQ AGRFKAVTIA TNMAGRGTDI 500
    MLGGNPEMLI EQLDEDHNYE TKAAEIKAQI SEEKKQVIEA GGLFVIGTER 550
    HESRRIDNQL RGRSGRQGDP GKTKFFLSLD DDLMRIFASD RISGVLRTLG 600
    LKDGEAIHHP MISRSLEKAQ QKVEGHNYEM RKNLLRFDDV MNDQRKIIYE 650
    QRTEIIKSKD SHGFLNSTTE ELAKKIVLTF MPVGSYREDW DIENLSVELH 700
    RVFSMKFDHN LVSKNDVTEE EITKIVIQTA HDIYKSKEEA YSSELMHNAV 750
    KYILLTTLDQ VWKDHLYSLD HLRQGISLRA YAQKDPLSEY KREAFNLFEQ 800
    MLNNLKELFI QTVYHFHIDL KHIQKEDVSL EHKKLQKNMR ESREDPAFSK 850
    YNAGSSLETD LKPVVSRVDP KDRNPDDPTS WGRVSRNELC PCGSGKKYKY 900
    CHGANE 906
    Length:906
    Mass (Da):103,324
    Last modified:July 5, 2005 - v1
    Checksum:iC3229F5E6BBE415F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61792.1.
    RefSeqiYP_246957.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61792; AAY61792; RF_0941.
    GeneIDi3400947.
    KEGGirfe:RF_0941.
    PATRICi17892621. VBIRicFel64634_1130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61792.1 .
    RefSeqi YP_246957.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKY1.
    SMRi Q4UKY1. Positions 13-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61792 ; AAY61792 ; RF_0941 .
    GeneIDi 3400947.
    KEGGi rfe:RF_0941.
    PATRICi 17892621. VBIRicFel64634_1130.

    Phylogenomic databases

    eggNOGi COG0653.
    HOGENOMi HOG000218168.
    KOi K03070.
    OMAi EAYEFQQ.
    OrthoDBi EOG654P48.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-968-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPi MF_01382. SecA.
    InterProi IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view ]
    Pfami PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view ]
    PRINTSi PR00906. SECA.
    SMARTi SM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsi TIGR00963. secA. 1 hit.
    PROSITEi PS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSECA_RICFE
    AccessioniPrimary (citable) accession number: Q4UKY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3