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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi890 – 8901ZincUniRule annotation
Metal bindingi892 – 8921ZincUniRule annotation
Metal bindingi901 – 9011ZincUniRule annotation
Metal bindingi902 – 9021ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:RF_0941
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Protein translocase subunit SecAPRO_0000277301Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0941.

Structurei

3D structure databases

ProteinModelPortaliQ4UKY1.
SMRiQ4UKY1. Positions 13-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSILKKLFG TANDRTVKKL FSEITKINSL EPAIQKLSDE ELKNKTVEFK
60 70 80 90 100
EKLKNGATLD DIVYEAFAVV REAARRVCGM RHFDVQLIGG LILHRGMITE
110 120 130 140 150
MRTGEGKTLV ATLPAYLNAL TGKGVHVVTV NDYLASRDSA SMGKIYNFLG
160 170 180 190 200
LSVGCIVAGM PDEAKRAAYN ADITHATNNE LGFDYLRDNM KYSLQERVLR
210 220 230 240 250
PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKIDK IVRMLNTSDF
260 270 280 290 300
EKDEKLKTIN LTETGITHIE SLLSKEHLIK PDTGLYDFEN LTLVHYVNQA
310 320 330 340 350
LRAHNMFTVD VDYLVREGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV
360 370 380 390 400
KIQNENQTLA SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP
410 420 430 440 450
THNKVTRLDL DDEIYGSKKE KYDAILKLIK DCYDRGQPIL VGTISIEKSE
460 470 480 490 500
ELSSVLNKEK IPHKVLNAKF HEQEAFIIAQ AGRFKAVTIA TNMAGRGTDI
510 520 530 540 550
MLGGNPEMLI EQLDEDHNYE TKAAEIKAQI SEEKKQVIEA GGLFVIGTER
560 570 580 590 600
HESRRIDNQL RGRSGRQGDP GKTKFFLSLD DDLMRIFASD RISGVLRTLG
610 620 630 640 650
LKDGEAIHHP MISRSLEKAQ QKVEGHNYEM RKNLLRFDDV MNDQRKIIYE
660 670 680 690 700
QRTEIIKSKD SHGFLNSTTE ELAKKIVLTF MPVGSYREDW DIENLSVELH
710 720 730 740 750
RVFSMKFDHN LVSKNDVTEE EITKIVIQTA HDIYKSKEEA YSSELMHNAV
760 770 780 790 800
KYILLTTLDQ VWKDHLYSLD HLRQGISLRA YAQKDPLSEY KREAFNLFEQ
810 820 830 840 850
MLNNLKELFI QTVYHFHIDL KHIQKEDVSL EHKKLQKNMR ESREDPAFSK
860 870 880 890 900
YNAGSSLETD LKPVVSRVDP KDRNPDDPTS WGRVSRNELC PCGSGKKYKY

CHGANE
Length:906
Mass (Da):103,324
Last modified:July 5, 2005 - v1
Checksum:iC3229F5E6BBE415F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61792.1.
RefSeqiWP_011271264.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61792; AAY61792; RF_0941.
KEGGirfe:RF_0941.
PATRICi17892621. VBIRicFel64634_1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61792.1.
RefSeqiWP_011271264.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UKY1.
SMRiQ4UKY1. Positions 13-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61792; AAY61792; RF_0941.
KEGGirfe:RF_0941.
PATRICi17892621. VBIRicFel64634_1130.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-968-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSECA_RICFE
AccessioniPrimary (citable) accession number: Q4UKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.