ID   PLP_RICFE               Reviewed;         282 AA.
AC   Q4UKY0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=Parvulin-like PPIase;
DE            EC=5.2.1.8;
DE   AltName: Full=Peptidyl-prolyl cis-trans isomerase plp;
DE   AltName: Full=Rotamase plp;
DE   Flags: Precursor;
GN   Name=plp; OrderedLocusNames=RF_0942;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PpiC/parvulin rotamase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000053; AAY61793.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4UKY0; -.
DR   SMR; Q4UKY0; -.
DR   STRING; 315456.RF_0942; -.
DR   KEGG; rfe:RF_0942; -.
DR   eggNOG; COG0760; Bacteria.
DR   HOGENOM; CLU_034646_1_3_5; -.
DR   OrthoDB; 14196at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   PANTHER; PTHR47245:SF1; FOLDASE PROTEIN PRSA; 1.
DR   PANTHER; PTHR47245; PEPTIDYLPROLYL ISOMERASE; 1.
DR   Pfam; PF13616; Rotamase_3; 1.
DR   SUPFAM; SSF54534; FKBP-like; 1.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Isomerase; Membrane; Rotamase; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..282
FT                   /note="Parvulin-like PPIase"
FT                   /id="PRO_0000289286"
FT   DOMAIN          138..231
FT                   /note="PpiC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
SQ   SEQUENCE   282 AA;  31350 MW;  7B9CCEDE9FA882BF CRC64;
     MKKLSVIFLS VSMLSGIAFA DKDKVVATYK GGEVKESQIM KEFKPQLNLQ SGETIKNFDD
     FPPQDQEKLI KIYVNNLLLK EEVAKSNITS SKEFQEKLEN AKNQLAQQEL LANYIKSNIT
     DKMFDDEYNK YVGNLKGKEQ IKVAHILVKS QKEANNIKTK LSKGGNFTKL AEESSLDKAS
     ASNGGVIGYI LLNQPGQLVP EFEKKAFALK VNEVSTPVKT DFGWHIIKVL EKKPVPIPTK
     EEAKVTIDNI LAAEVLKKYI SDLEAKADLK IMLPKAGSKA GS
//