Q4UKW3 (SECD_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecD

Gene names

Name:	secD
Ordered Locus Names:	RF_0959

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA By similarity. HAMAP-Rule MF_01463
Subunit structure	Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01463.
Sequence similarities	Belongs to the SecD/SecF family. SecD subfamily.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein targeting Inferred from electronic annotation. Source: HAMAP protein transport by the Sec complex Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Protein translocase subunit SecD HAMAP-Rule MF_01463		PRO_0000272635
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Transmembrane	406 – 426	21	Helical; Potential
	Transmembrane	452 – 474	23	Helical; Potential
	Transmembrane	486 – 506	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UKW3 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 208C69B570F1EDFF	FASTA	518	56,608
	10 20 30 40 50 60 MQNLPKWKIF LSIICTVFAV ICALPNFMQV NSKFLPHDSV NLGLDLRGGA HLLLDVDFDT 70 80 90 100 110 120 YLNDSMENLA DTLRKNFRED KIGYKNLLVR QNSIQLEVRS PEELKPLKKI INKIDPEIIA 130 140 150 160 170 180 EVNENKIKLS YSESRLNDLL NKVVDQSIEI VRMRVDSTGT KEPTLQKQGD KHILLQVPGE 190 200 210 220 230 240 ENPSYLKNIL GKTAKLTFHL VDENANIEEA VKGHVPVGSM LVKGDSESHR EYYVVIKKKV 250 260 270 280 290 300 VLGGDQLTTA SASFDQNSQA VVAFSFNNLG SKIFGEITKN NTGKRLAIVL DNKLLSAPTI 310 320 330 340 350 360 NGAIMGGSGI ITGNFTVESA NELALLLRAG SLPAPLKIIE ERSIGPSLGA DSIESGKKAG 370 380 390 400 410 420 LIGFIAVCIF MVWSYGVLGL FANIALSLAL LYILALLSLF QATLTLPGIA GIILTMGMAV 430 440 450 460 470 480 DANVLIYERI KEELHKGVSN LYAIRTGFES AFATILDSNL TTLIVAFLLY IFGVGAIKGF 490 500 510 AVALTIGIIS SMFSAIIITK LLIDIWVKYF IPKKLGLV

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61810.1.
RefSeq	YP_246975.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UKW3.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0959.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61810; AAY61810; RF_0959.
GeneID	3400967.
KEGG	rfe:RF_0959.
PATRIC	17892665. VBIRicFel64634_1150.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0342.
HOGENOM	HOG000018636.
KO	K03072.
OMA	VNLWYGR.
ProtClustDB	PRK05812.
Family and domain databases
HAMAP	MF_01463_B. SecD_B.
InterPro	IPR001036. Acrflvin-R. IPR005791. SecD. IPR022813. SecD/SecF. IPR022645. SecD/SecF_bac. IPR022646. SecD/SecF_CS. [Graphical view]
Pfam	PF07549. Sec_GG. 1 hit. PF02355. SecD_SecF. 1 hit. [Graphical view]
PRINTS	PR00702. ACRIFLAVINRP.
TIGRFAMs	TIGR00916. 2A0604s01. 1 hit. TIGR01129. secD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SECD_RICFE

Accession

Primary (citable) accession number: Q4UKW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program