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Protein

Protein translocase subunit SecD

Gene

secD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-988-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecDUniRule annotation
Gene namesi
Name:secDUniRule annotation
Ordered Locus Names:RF_0959
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei361 – 38121HelicalUniRule annotationAdd
BLAST
Transmembranei384 – 40421HelicalUniRule annotationAdd
BLAST
Transmembranei406 – 42621HelicalUniRule annotationAdd
BLAST
Transmembranei452 – 47423HelicalUniRule annotationAdd
BLAST
Transmembranei486 – 50621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Protein translocase subunit SecDPRO_0000272635Add
BLAST

Interactioni

Subunit structurei

Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0959.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0342.
HOGENOMiHOG000018636.
KOiK03072.
OMAiAAPMEII.
OrthoDBiEOG6N0HJT.

Family and domain databases

HAMAPiMF_01463_B. SecD_B.
InterProiIPR001036. Acrflvin-R.
IPR005791. SecD.
IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR01129. secD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNLPKWKIF LSIICTVFAV ICALPNFMQV NSKFLPHDSV NLGLDLRGGA
60 70 80 90 100
HLLLDVDFDT YLNDSMENLA DTLRKNFRED KIGYKNLLVR QNSIQLEVRS
110 120 130 140 150
PEELKPLKKI INKIDPEIIA EVNENKIKLS YSESRLNDLL NKVVDQSIEI
160 170 180 190 200
VRMRVDSTGT KEPTLQKQGD KHILLQVPGE ENPSYLKNIL GKTAKLTFHL
210 220 230 240 250
VDENANIEEA VKGHVPVGSM LVKGDSESHR EYYVVIKKKV VLGGDQLTTA
260 270 280 290 300
SASFDQNSQA VVAFSFNNLG SKIFGEITKN NTGKRLAIVL DNKLLSAPTI
310 320 330 340 350
NGAIMGGSGI ITGNFTVESA NELALLLRAG SLPAPLKIIE ERSIGPSLGA
360 370 380 390 400
DSIESGKKAG LIGFIAVCIF MVWSYGVLGL FANIALSLAL LYILALLSLF
410 420 430 440 450
QATLTLPGIA GIILTMGMAV DANVLIYERI KEELHKGVSN LYAIRTGFES
460 470 480 490 500
AFATILDSNL TTLIVAFLLY IFGVGAIKGF AVALTIGIIS SMFSAIIITK
510
LLIDIWVKYF IPKKLGLV
Length:518
Mass (Da):56,608
Last modified:July 5, 2005 - v1
Checksum:i208C69B570F1EDFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61810.1.
RefSeqiYP_246975.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61810; AAY61810; RF_0959.
KEGGirfe:RF_0959.
PATRICi17892665. VBIRicFel64634_1150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61810.1.
RefSeqiYP_246975.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61810; AAY61810; RF_0959.
KEGGirfe:RF_0959.
PATRICi17892665. VBIRicFel64634_1150.

Phylogenomic databases

eggNOGiCOG0342.
HOGENOMiHOG000018636.
KOiK03072.
OMAiAAPMEII.
OrthoDBiEOG6N0HJT.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-988-MONOMER.

Family and domain databases

HAMAPiMF_01463_B. SecD_B.
InterProiIPR001036. Acrflvin-R.
IPR005791. SecD.
IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR01129. secD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSECD_RICFE
AccessioniPrimary (citable) accession number: Q4UKW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: April 29, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.