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Q4UKW1

- CCME_RICFE

UniProt

Q4UKW1 - CCME_RICFE

Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
    Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW
    2. protein-heme linkage Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cytochrome c-type biogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-990-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-type biogenesis protein CcmEUniRule annotation
    Alternative name(s):
    Cytochrome c maturation protein EUniRule annotation
    Heme chaperone CcmEUniRule annotation
    Gene namesi
    Name:ccmEUniRule annotation
    Synonyms:cycJUniRule annotation
    Ordered Locus Names:RF_0961
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128128Cytochrome c-type biogenesis protein CcmEPRO_0000238856Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicUniRule annotation
    Topological domaini30 – 12899PeriplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CcmE/CycJ family.UniRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2332.
    HOGENOMiHOG000009661.
    KOiK02197.
    OMAiENYMPRE.
    OrthoDBiEOG69D3JN.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01959. CcmE.
    InterProiIPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF03100. CcmE. 1 hit.
    [Graphical view]
    SUPFAMiSSF82093. SSF82093. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UKW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKRVRNRLI TIIICFCSAA LGISIVLYNL EKNIVFFLPP SKINEIEQGK    50
    ELRVGGLVKI DSINKIAADK ISFVITDNIR DLEILYQGVL PALFREGQGI 100
    IAIGQLSDGK FIARQLLAKH DENYRPPS 128
    Length:128
    Mass (Da):14,351
    Last modified:July 5, 2005 - v1
    Checksum:i9F96E756A87B6677
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61812.1.
    RefSeqiYP_246977.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61812; AAY61812; RF_0961.
    GeneIDi3400969.
    KEGGirfe:RF_0961.
    PATRICi17892669. VBIRicFel64634_1152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61812.1 .
    RefSeqi YP_246977.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61812 ; AAY61812 ; RF_0961 .
    GeneIDi 3400969.
    KEGGi rfe:RF_0961.
    PATRICi 17892669. VBIRicFel64634_1152.

    Phylogenomic databases

    eggNOGi COG2332.
    HOGENOMi HOG000009661.
    KOi K02197.
    OMAi ENYMPRE.
    OrthoDBi EOG69D3JN.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-990-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01959. CcmE.
    InterProi IPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF03100. CcmE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82093. SSF82093. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiCCME_RICFE
    AccessioniPrimary (citable) accession number: Q4UKW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3