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Q4UKW1 (CCME_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene names
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:RF_0961
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959

Subcellular location

Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.

Sequence similarities

Belongs to the CcmE/CycJ family.

Ontologies

Keywords
   Biological processCytochrome c-type biogenesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandHeme
Iron
Metal-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcytochrome complex assembly

Inferred from electronic annotation. Source: UniProtKB-KW

protein-heme linkage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959
PRO_0000238856

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 12899Periplasmic Potential

Sites

Metal binding1241Iron (heme axial ligand) By similarity
Binding site1201Heme (covalent; via pros nitrogen) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UKW1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 9F96E756A87B6677

FASTA12814,351
        10         20         30         40         50         60 
MQKRVRNRLI TIIICFCSAA LGISIVLYNL EKNIVFFLPP SKINEIEQGK ELRVGGLVKI 

        70         80         90        100        110        120 
DSINKIAADK ISFVITDNIR DLEILYQGVL PALFREGQGI IAIGQLSDGK FIARQLLAKH 


DENYRPPS 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61812.1.
RefSeqYP_246977.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKW1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61812; AAY61812; RF_0961.
GeneID3400969.
KEGGrfe:RF_0961.
PATRIC17892669. VBIRicFel64634_1152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2332.
HOGENOMHOG000009661.
KOK02197.
OMAGPDQNVE.
OrthoDBEOG69D3JN.
ProtClustDBPRK13254.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-990-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01959. CcmE.
InterProIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMSSF82093. SSF82093. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCME_RICFE
AccessionPrimary (citable) accession number: Q4UKW1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names