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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-990-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:RF_0961
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicUniRule annotation
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
BLAST
Topological domaini30 – 12899PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Cytochrome c-type biogenesis protein CcmEPRO_0000238856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0961.

Structurei

3D structure databases

ProteinModelPortaliQ4UKW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZKK. Bacteria.
COG2332. LUCA.
HOGENOMiHOG000009661.
KOiK02197.
OMAiGPDQNVE.
OrthoDBiPOG091H05S8.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRVRNRLI TIIICFCSAA LGISIVLYNL EKNIVFFLPP SKINEIEQGK
60 70 80 90 100
ELRVGGLVKI DSINKIAADK ISFVITDNIR DLEILYQGVL PALFREGQGI
110 120
IAIGQLSDGK FIARQLLAKH DENYRPPS
Length:128
Mass (Da):14,351
Last modified:July 5, 2005 - v1
Checksum:i9F96E756A87B6677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61812.1.
RefSeqiWP_011271284.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61812; AAY61812; RF_0961.
KEGGirfe:RF_0961.
PATRICi17892669. VBIRicFel64634_1152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61812.1.
RefSeqiWP_011271284.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UKW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61812; AAY61812; RF_0961.
KEGGirfe:RF_0961.
PATRICi17892669. VBIRicFel64634_1152.

Phylogenomic databases

eggNOGiENOG4108ZKK. Bacteria.
COG2332. LUCA.
HOGENOMiHOG000009661.
KOiK02197.
OMAiGPDQNVE.
OrthoDBiPOG091H05S8.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-990-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCME_RICFE
AccessioniPrimary (citable) accession number: Q4UKW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.