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Q4UKW1

- CCME_RICFE

UniProt

Q4UKW1 - CCME_RICFE

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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
  2. protein-heme linkage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-990-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:RF_0961
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Cytochrome c-type biogenesis protein CcmEPRO_0000238856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0961.

Structurei

3D structure databases

ProteinModelPortaliQ4UKW1.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicUniRule annotation
Topological domaini30 – 12899PeriplasmicUniRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiENYMPRE.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKRVRNRLI TIIICFCSAA LGISIVLYNL EKNIVFFLPP SKINEIEQGK
60 70 80 90 100
ELRVGGLVKI DSINKIAADK ISFVITDNIR DLEILYQGVL PALFREGQGI
110 120
IAIGQLSDGK FIARQLLAKH DENYRPPS
Length:128
Mass (Da):14,351
Last modified:July 5, 2005 - v1
Checksum:i9F96E756A87B6677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61812.1.
RefSeqiWP_011271284.1. NC_007109.1.
YP_246977.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61812; AAY61812; RF_0961.
GeneIDi3400969.
KEGGirfe:RF_0961.
PATRICi17892669. VBIRicFel64634_1152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61812.1 .
RefSeqi WP_011271284.1. NC_007109.1.
YP_246977.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61812 ; AAY61812 ; RF_0961 .
GeneIDi 3400969.
KEGGi rfe:RF_0961.
PATRICi 17892669. VBIRicFel64634_1152.

Phylogenomic databases

eggNOGi COG2332.
HOGENOMi HOG000009661.
KOi K02197.
OMAi ENYMPRE.
OrthoDBi EOG69D3JN.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-990-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_01959. CcmE.
InterProi IPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF03100. CcmE. 1 hit.
[Graphical view ]
SUPFAMi SSF82093. SSF82093. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCCME_RICFE
AccessioniPrimary (citable) accession number: Q4UKW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3