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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1UniRule annotation
Metal bindingi70 – 701Magnesium 1UniRule annotation
Metal bindingi70 – 701Magnesium 2UniRule annotation
Metal bindingi102 – 1021Magnesium 1UniRule annotation

GO - Molecular functioni

  1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-991-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:RF_0962
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Inorganic pyrophosphatasePRO_0000278036Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0962.

Structurei

3D structure databases

ProteinModelPortaliQ4UKW0.
SMRiQ4UKW0. Positions 2-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0221.
HOGENOMiHOG000236473.
KOiK01507.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDKIKAKA NNDEINVIIE IPMNIGPIKY EFDKESGAVF VDRFMQTTMS
60 70 80 90 100
YPCNYGFIPH TLSNDGDPVD VLVVAHHPVV PGSVIKCRAV GVLMMEDESG
110 120 130 140 150
LDEKIIAVPT SKLDITFDHI KELDDLCEML KKRIVHFFEH YKDLEKGKWV
160 170
KVTGWENKAK ANALINEGID RAS
Length:173
Mass (Da):19,551
Last modified:February 20, 2007 - v2
Checksum:i50C73DDA61C42B4B
GO

Sequence cautioni

The sequence AAY61813.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61813.1. Different initiation.
RefSeqiYP_246978.2. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61813; AAY61813; RF_0962.
KEGGirfe:RF_0962.
PATRICi17892671. VBIRicFel64634_1153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61813.1. Different initiation.
RefSeqiYP_246978.2. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UKW0.
SMRiQ4UKW0. Positions 2-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61813; AAY61813; RF_0962.
KEGGirfe:RF_0962.
PATRICi17892671. VBIRicFel64634_1153.

Phylogenomic databases

eggNOGiCOG0221.
HOGENOMiHOG000236473.
KOiK01507.
OrthoDBiEOG6NKR4X.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-991-MONOMER.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiIPYR_RICFE
AccessioniPrimary (citable) accession number: Q4UKW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 1, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.