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Q4UKW0

- IPYR_RICFE

UniProt

Q4UKW0 - IPYR_RICFE

Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.UniRule annotation

    Cofactori

    Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Magnesium 1UniRule annotation
    Metal bindingi70 – 701Magnesium 1UniRule annotation
    Metal bindingi70 – 701Magnesium 2UniRule annotation
    Metal bindingi102 – 1021Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-991-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
    Alternative name(s):
    Pyrophosphate phospho-hydrolaseUniRule annotation
    Short name:
    PPaseUniRule annotation
    Gene namesi
    Name:ppaUniRule annotation
    Ordered Locus Names:RF_0962
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Inorganic pyrophosphatasePRO_0000278036Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0962.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKW0.
    SMRiQ4UKW0. Positions 2-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0221.
    HOGENOMiHOG000236473.
    KOiK01507.
    OMAiKNMFIDK.
    OrthoDBiEOG6NKR4X.

    Family and domain databases

    Gene3Di3.90.80.10. 1 hit.
    HAMAPiMF_00209. Inorganic_PPase.
    InterProiIPR008162. Pyrophosphatase.
    [Graphical view]
    PANTHERiPTHR10286. PTHR10286. 1 hit.
    PfamiPF00719. Pyrophosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50324. SSF50324. 1 hit.
    PROSITEiPS00387. PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIDKIKAKA NNDEINVIIE IPMNIGPIKY EFDKESGAVF VDRFMQTTMS    50
    YPCNYGFIPH TLSNDGDPVD VLVVAHHPVV PGSVIKCRAV GVLMMEDESG 100
    LDEKIIAVPT SKLDITFDHI KELDDLCEML KKRIVHFFEH YKDLEKGKWV 150
    KVTGWENKAK ANALINEGID RAS 173
    Length:173
    Mass (Da):19,551
    Last modified:February 20, 2007 - v2
    Checksum:i50C73DDA61C42B4B
    GO

    Sequence cautioni

    The sequence AAY61813.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61813.1. Different initiation.
    RefSeqiYP_246978.2. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61813; AAY61813; RF_0962.
    GeneIDi3400970.
    KEGGirfe:RF_0962.
    PATRICi17892671. VBIRicFel64634_1153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61813.1 . Different initiation.
    RefSeqi YP_246978.2. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKW0.
    SMRi Q4UKW0. Positions 2-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0962.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61813 ; AAY61813 ; RF_0962 .
    GeneIDi 3400970.
    KEGGi rfe:RF_0962.
    PATRICi 17892671. VBIRicFel64634_1153.

    Phylogenomic databases

    eggNOGi COG0221.
    HOGENOMi HOG000236473.
    KOi K01507.
    OMAi KNMFIDK.
    OrthoDBi EOG6NKR4X.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-991-MONOMER.

    Family and domain databases

    Gene3Di 3.90.80.10. 1 hit.
    HAMAPi MF_00209. Inorganic_PPase.
    InterProi IPR008162. Pyrophosphatase.
    [Graphical view ]
    PANTHERi PTHR10286. PTHR10286. 1 hit.
    Pfami PF00719. Pyrophosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50324. SSF50324. 1 hit.
    PROSITEi PS00387. PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiIPYR_RICFE
    AccessioniPrimary (citable) accession number: Q4UKW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3