SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UKW0

- IPYR_RICFE

UniProt

Q4UKW0 - IPYR_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inorganic pyrophosphatase

Gene
ppa, RF_0962
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1 By similarity
Metal bindingi70 – 701Magnesium 1 By similarity
Metal bindingi70 – 701Magnesium 2 By similarity
Metal bindingi102 – 1021Magnesium 1 By similarity

GO - Molecular functioni

  1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-991-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:RF_0962
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Inorganic pyrophosphataseUniRule annotationPRO_0000278036Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0962.

Structurei

3D structure databases

ProteinModelPortaliQ4UKW0.
SMRiQ4UKW0. Positions 2-171.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.

Phylogenomic databases

eggNOGiCOG0221.
HOGENOMiHOG000236473.
KOiK01507.
OMAiKNMFIDK.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKW0-1 [UniParc]FASTAAdd to Basket

« Hide

MFIDKIKAKA NNDEINVIIE IPMNIGPIKY EFDKESGAVF VDRFMQTTMS    50
YPCNYGFIPH TLSNDGDPVD VLVVAHHPVV PGSVIKCRAV GVLMMEDESG 100
LDEKIIAVPT SKLDITFDHI KELDDLCEML KKRIVHFFEH YKDLEKGKWV 150
KVTGWENKAK ANALINEGID RAS 173
Length:173
Mass (Da):19,551
Last modified:February 20, 2007 - v2
Checksum:i50C73DDA61C42B4B
GO

Sequence cautioni

The sequence AAY61813.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61813.1. Different initiation.
RefSeqiYP_246978.2. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61813; AAY61813; RF_0962.
GeneIDi3400970.
KEGGirfe:RF_0962.
PATRICi17892671. VBIRicFel64634_1153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61813.1 . Different initiation.
RefSeqi YP_246978.2. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKW0.
SMRi Q4UKW0. Positions 2-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61813 ; AAY61813 ; RF_0962 .
GeneIDi 3400970.
KEGGi rfe:RF_0962.
PATRICi 17892671. VBIRicFel64634_1153.

Phylogenomic databases

eggNOGi COG0221.
HOGENOMi HOG000236473.
KOi K01507.
OMAi KNMFIDK.
OrthoDBi EOG6NKR4X.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-991-MONOMER.

Family and domain databases

Gene3Di 3.90.80.10. 1 hit.
HAMAPi MF_00209. Inorganic_PPase.
InterProi IPR008162. Pyrophosphatase.
[Graphical view ]
PANTHERi PTHR10286. PTHR10286. 1 hit.
Pfami PF00719. Pyrophosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF50324. SSF50324. 1 hit.
PROSITEi PS00387. PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiIPYR_RICFE
AccessioniPrimary (citable) accession number: Q4UKW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi