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Q4UKU3

- SYT_RICFE

UniProt

Q4UKU3 - SYT_RICFE

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi333 – 3331Zinc; catalyticUniRule annotation
    Metal bindingi384 – 3841Zinc; catalyticUniRule annotation
    Metal bindingi510 – 5101Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1008-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:RF_0979
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Threonine--tRNA ligasePRO_0000101037Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKU3.
    SMRiQ4UKU3. Positions 241-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 533292CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003880.
    KOiK01868.
    OMAiHFKLQKI.
    OrthoDBiEOG61KBFJ.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINISFPDGS VKQFESNITA FEVANAISMS LAKAAMVAEI NGELKDLSTI    50
    IENDCKLRIL TAKDSECLEI IRHDAAHIIA EAAKELFPDI QVTIGPAIEN 100
    GFFYDFAKDK PFTPDDVAMI EARMHEIVKR NEQITRELWD RDKAVEFFKS 150
    IGEHYKAEII ASIPAGEPIT LYRQGSFIDL CRGPHAPSTG FVKHFKLMKV 200
    AGAYWRGDSR NEMLQRIYGT AWATKEQLDN YLFMLEEAEK RDHRKLGREL 250
    DLFHFQEEAQ GMVFWHDKGW SIYNTIEQYI RKKIRKNGYT EVKTPVLVDK 300
    SLWEASGHWE KFREDMFALE TDDKTLALKP MNCPCHVQIF KQGIKSYRDL 350
    PLRMSEFGLC HRNEASGALH GLMRVRSLVQ DDAHIFCAEE QITDETVSFC 400
    KLLTEVYKDF GFTDIKVKFS DRPEIRAGSD EVWDKAENAL KEAVEKAGFT 450
    YTLNPGEGAF YGPKLEFVLT DAIGRQWQCG TLQMDFVLPE RLDASYIAAS 500
    GEKKRPVMLH RAILGSLERF IGILIEEYAG RFPIWLAPIQ VAIATITSDL 550
    NDYALEVQKA LIDNGVRTDI NISPDKINYK IREFSNQKIP MIAVIGKQEK 600
    ENKHVTIRRL GTTDQEVLSI EQLIALIKKE NEKYL 635
    Length:635
    Mass (Da):72,589
    Last modified:July 5, 2005 - v1
    Checksum:i3B11869BA3758CB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61830.1.
    RefSeqiYP_246995.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61830; AAY61830; RF_0979.
    GeneIDi3400987.
    KEGGirfe:RF_0979.
    PATRICi17892707. VBIRicFel64634_1171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61830.1 .
    RefSeqi YP_246995.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKU3.
    SMRi Q4UKU3. Positions 241-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61830 ; AAY61830 ; RF_0979 .
    GeneIDi 3400987.
    KEGGi rfe:RF_0979.
    PATRICi 17892707. VBIRicFel64634_1171.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003880.
    KOi K01868.
    OMAi HFKLQKI.
    OrthoDBi EOG61KBFJ.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1008-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSYT_RICFE
    AccessioniPrimary (citable) accession number: Q4UKU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3