Q4UKS5 (PHS_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative pterin-4-alpha-carbinolamine dehydratase
Short name=PHS
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase
Short name=PCD

Gene names

Ordered Locus Names:

RF_0997

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. HAMAP-Rule MF_00434
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Putative pterin-4-alpha-carbinolamine dehydratase HAMAP-Rule MF_00434		PRO_0000231473

Sequences

	Sequence		Length	Mass (Da)
	Q4UKS5 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 3F9E4FB1F2C7EC6C	FASTA	110	12,512
	10 20 30 40 50 60 MTVLSEKKCI PCEGGIPPLE KKEIDKLLVQ LQSKWQVNEL GHLYKKYKFP NFVKAMEFAN 70 80 90 100 110 KITEIAEQEA HHPDLTISWG ACSVEIWTHK IDGLTESDFI LAAKIESINS

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61848.1.
RefSeq	YP_247013.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UKS5.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0997.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61848; AAY61848; RF_0997.
GeneID	3401006.
KEGG	rfe:RF_0997.
PATRIC	17892755. VBIRicFel64634_1194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2154.
HOGENOM	HOG000007681.
KO	K01724.
OMA	ILTEWGK.
ProtClustDB	CLSK937597.
Family and domain databases
Gene3D	3.30.1360.20. 1 hit.
HAMAP	MF_00434. Pterin_4_alpha.
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
PANTHER	PTHR12599. PTHR12599. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS_RICFE

Accession

Primary (citable) accession number: Q4UKS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program