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Q4UKR6

- UCRI_RICFE

UniProt

Q4UKR6 - UCRI_RICFE

Protein

Ubiquinol-cytochrome c reductase iron-sulfur subunit

Gene

petA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

    Catalytic activityi

    Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi122 – 1221Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation
    Metal bindingi139 – 1391Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi142 – 1421Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. ubiquinol-cytochrome-c reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3082-MONOMER.
    RFEL315456:GKEK-1042-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC:1.10.2.2)
    Alternative name(s):
    Rieske iron-sulfur protein
    Short name:
    RISP
    Gene namesi
    Name:petA
    Ordered Locus Names:RF_1010
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177Ubiquinol-cytochrome c reductase iron-sulfur subunitPRO_0000286643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi125 ↔ 141PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

    Protein-protein interaction databases

    STRINGi315456.RF_1010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKR6.
    SMRiQ4UKR6. Positions 118-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 17588RieskePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rieske domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0723.
    HOGENOMiHOG000255193.
    KOiK00411.
    OMAiMIGSCTH.
    OrthoDBiEOG6RNQD9.

    Family and domain databases

    Gene3Di2.102.10.10. 1 hit.
    InterProiIPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    [Graphical view]
    PANTHERiPTHR10134. PTHR10134. 1 hit.
    PfamiPF00355. Rieske. 1 hit.
    PF10399. UCR_Fe-S_N. 1 hit.
    [Graphical view]
    PRINTSiPR00162. RIESKE.
    SUPFAMiSSF50022. SSF50022. 1 hit.
    TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
    TIGR01409. TAT_signal_seq. 1 hit.
    PROSITEiPS51296. RIESKE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTEDNKNK QTTRRDFMVL TASSVAAVGA VCTLWPLVDS LNPSADVLAL    50
    SSIEVDLSNI AVGQTVTVKW QGKPVFITNR TPDKIAEARA VKMSELIDPE 100
    TDEARVKAGH DNWLVTIGIC THLGCVPLAN QGEYDGWFCP CHGSQYDSSG 150
    RVRRGPAPLN LAVPPYTFIS DKKIRIG 177
    Length:177
    Mass (Da):19,228
    Last modified:July 5, 2005 - v1
    Checksum:i8F500C77E8FD743D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61861.1.
    RefSeqiYP_247026.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61861; AAY61861; RF_1010.
    GeneIDi3401020.
    KEGGirfe:RF_1010.
    PATRICi17892785. VBIRicFel64634_1208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61861.1 .
    RefSeqi YP_247026.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKR6.
    SMRi Q4UKR6. Positions 118-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61861 ; AAY61861 ; RF_1010 .
    GeneIDi 3401020.
    KEGGi rfe:RF_1010.
    PATRICi 17892785. VBIRicFel64634_1208.

    Phylogenomic databases

    eggNOGi COG0723.
    HOGENOMi HOG000255193.
    KOi K00411.
    OMAi MIGSCTH.
    OrthoDBi EOG6RNQD9.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-3082-MONOMER.
    RFEL315456:GKEK-1042-MONOMER.

    Family and domain databases

    Gene3Di 2.102.10.10. 1 hit.
    InterProi IPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    [Graphical view ]
    PANTHERi PTHR10134. PTHR10134. 1 hit.
    Pfami PF00355. Rieske. 1 hit.
    PF10399. UCR_Fe-S_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00162. RIESKE.
    SUPFAMi SSF50022. SSF50022. 1 hit.
    TIGRFAMsi TIGR01416. Rieske_proteo. 1 hit.
    TIGR01409. TAT_signal_seq. 1 hit.
    PROSITEi PS51296. RIESKE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiUCRI_RICFE
    AccessioniPrimary (citable) accession number: Q4UKR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The Rieske protein is a high potential 2Fe-2S protein.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3