Reviewed,
UniProtKB/Swiss-Prot Q4UKR6 (UCRI_RICFE)
Last modified
November 3, 2009.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquinol-cytochrome c reductase iron-sulfur subunit EC=1.10.2.2 Alternative name(s): Rieske iron-sulfur protein Short name=RISP | ||||
| Gene names |
| ||||
| Organism | Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 42862 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group |
Protein attributes
| Sequence length | 177 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. |
| Catalytic activity | QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+. |
| Cofactor | Binds 1 2Fe-2S cluster per subunit By similarity. |
| Subunit structure | The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. |
| Subcellular location | Cell membrane; Single-pass membrane protein Potential. |
| Miscellaneous | The Rieske protein is a high potential 2Fe-2S protein. |
| Sequence similarities | Contains 1 Rieske domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | 2Fe-2S Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 177 | 177 | Ubiquinol-cytochrome c reductase iron-sulfur subunit | PRO_0000286643 | |||||||
Regions | |||||||||||
| Transmembrane | 18 – 38 | 21 | Potential | ||||||||
| Domain | 88 – 175 | 88 | Rieske | ||||||||
Sites | |||||||||||
| Metal binding | 120 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 122 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
| Metal binding | 139 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 142 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 125 ↔ 141 | By similarity | |||||||||
Sequences
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References
| [1] | "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2. |
Cross-references
Sequence databases | |
|---|---|
| CP000053 Genomic DNA. Translation: AAY61861.1. | |
| RefSeq | YP_247026.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3401020. |
| GenomeReviews | Gene locus RF_1010 in contig CP000053_GR. |
| KEGG | rfe:RF_1010. |
| NMPDR | fig|315456.3.peg.1010. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q4UKR6. |
| OMA | VVGICSH. |
Enzyme and pathway databases | |
| BioCyc | RFEL315456:RF_1010-MON. |
| BRENDA | 1.10.2.2. 297363. |
Family and domain databases | |
| InterPro | IPR017941. Rieske_2Fe-2S. IPR014349. Rieske_Fe-S_prot. IPR005805. Rieske_Fe-S_prot_C. IPR006311. TAT_signal. IPR017909. Twin_arg_translocation_Tat. IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT. IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su. [Graphical view] |
| Gene3D | G3DSA:2.102.10.10. Rieske_reg. 1 hit. |
| PANTHER | PTHR10134. Rieske. 1 hit. |
| Pfam | PF00355. Rieske. 1 hit. PF10399. UCR_Fe-S_N. 1 hit. [Graphical view] |
| PRINTS | PR00162. RIESKE. |
| TIGRFAMs | TIGR01416. Rieske_proteo. 1 hit. TIGR01409. TAT_signal_seq. 1 hit. |
| PROSITE | PS51296. RIESKE. 1 hit. PS51318. TAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UCRI_RICFE | ||||||||
| Accession | Primary (citable) accession number: Q4UKR6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Rickettsia felis (Rickettsia azadi) Rickettsia felis (strain URRWXCal2): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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