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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89SubstrateBy similarity1
Binding sitei99SubstrateBy similarity1
Binding sitei121SubstrateBy similarity1
Sitei128Critical for catalysisBy similarity1
Sitei175Critical for catalysisBy similarity1
Metal bindingi208Magnesium or manganeseBy similarity1
Binding sitei208SubstrateBy similarity1
Metal bindingi232Magnesium or manganeseBy similarity1
Metal bindingi236Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RF_1015
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002922031 – 483Isocitrate dehydrogenase [NADP]Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1015.

Structurei

3D structure databases

ProteinModelPortaliQ4UKR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0C. Bacteria.
COG0473. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY
60 70 80 90 100
TSGISEESWE SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP
110 120 130 140 150
SVSFHPFTMT LHPHLNLTII RENEEDLYAG IEYRQTHNMY ESIKLISHTG
160 170 180 190 200
CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGVFHKIF NEIAKEYPQI
210 220 230 240 250
NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS
260 270 280 290 300
ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL
310 320 330 340 350
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK
360 370 380 390 400
ADYPLIAEKQ ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL
410 420 430 440 450
DLGNIELKTI SSKGLKLWPR DTRFETISDH WCCRFMNKDG TEIKHLDITR
460 470 480
LLEALSKANI DFIKVENLFE FDGVAGYSLA QGE
Length:483
Mass (Da):54,062
Last modified:June 26, 2007 - v2
Checksum:i57322A4AD6884B3C
GO

Sequence cautioni

The sequence AAY61866 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqiWP_041405360.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61866; AAY61866; RF_1015.
KEGGirfe:RF_1015.
PATRICi17892797. VBIRicFel64634_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqiWP_041405360.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UKR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61866; AAY61866; RF_1015.
KEGGirfe:RF_1015.
PATRICi17892797. VBIRicFel64634_1214.

Phylogenomic databases

eggNOGiENOG4105C0C. Bacteria.
COG0473. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_RICFE
AccessioniPrimary (citable) accession number: Q4UKR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.