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Q4UKR1

- IDH_RICFE

UniProt

Q4UKR1 - IDH_RICFE

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, RF_1015
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891Substrate By similarity
Binding sitei99 – 991Substrate By similarity
Binding sitei121 – 1211Substrate By similarity
Sitei128 – 1281Critical for catalysis By similarity
Sitei175 – 1751Critical for catalysis By similarity
Metal bindingi208 – 2081Magnesium or manganese By similarity
Binding sitei208 – 2081Substrate By similarity
Metal bindingi232 – 2321Magnesium or manganese By similarity
Metal bindingi236 – 2361Magnesium or manganese By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RF_1015
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000292203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1015.

Structurei

3D structure databases

ProteinModelPortaliQ4UKR1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiMCMQLVM.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKR1-1 [UniParc]FASTAAdd to Basket

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MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY    50
TSGISEESWE SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP 100
SVSFHPFTMT LHPHLNLTII RENEEDLYAG IEYRQTHNMY ESIKLISHTG 150
CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGVFHKIF NEIAKEYPQI 200
NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS 250
ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL 300
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK 350
ADYPLIAEKQ ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL 400
DLGNIELKTI SSKGLKLWPR DTRFETISDH WCCRFMNKDG TEIKHLDITR 450
LLEALSKANI DFIKVENLFE FDGVAGYSLA QGE 483
Length:483
Mass (Da):54,062
Last modified:June 26, 2007 - v2
Checksum:i57322A4AD6884B3C
GO

Sequence cautioni

The sequence AAY61866.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqiYP_247031.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61866; AAY61866; RF_1015.
GeneIDi3401026.
KEGGirfe:RF_1015.
PATRICi17892797. VBIRicFel64634_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1 . Different initiation.
RefSeqi YP_247031.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61866 ; AAY61866 ; RF_1015 .
GeneIDi 3401026.
KEGGi rfe:RF_1015.
PATRICi 17892797. VBIRicFel64634_1214.

Phylogenomic databases

eggNOGi COG0473.
HOGENOMi HOG000021113.
KOi K00031.
OMAi MCMQLVM.
OrthoDBi EOG65XN31.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1047-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiIDH_RICFE
AccessioniPrimary (citable) accession number: Q4UKR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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