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Q4UKR1 (IDH_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Ordered Locus Names:RF_1015
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence caution

The sequence AAY61866.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000292203

Sites

Metal binding2081Magnesium or manganese By similarity
Metal binding2321Magnesium or manganese By similarity
Metal binding2361Magnesium or manganese By similarity
Binding site891Substrate By similarity
Binding site991Substrate By similarity
Binding site1211Substrate By similarity
Binding site2081Substrate By similarity
Site1281Critical for catalysis By similarity
Site1751Critical for catalysis By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UKR1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 57322A4AD6884B3C

FASTA48354,062
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY TSGISEESWE 

        70         80         90        100        110        120 
SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP SVSFHPFTMT LHPHLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESIKLISHTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK 

       190        200        210        220        230        240 
FSDGVFHKIF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK ADYPLIAEKQ 

       370        380        390        400        410        420 
ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL DLGNIELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETISDH WCCRFMNKDG TEIKHLDITR LLEALSKANI DFIKVENLFE FDGVAGYSLA 


QGE 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqYP_247031.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKR1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61866; AAY61866; RF_1015.
GeneID3401026.
KEGGrfe:RF_1015.
PATRIC17892797. VBIRicFel64634_1214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0473.
HOGENOMHOG000021113.
KOK00031.
OMAVIVRENM.
OrthoDBEOG65XN31.
ProtClustDBPRK09222.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1047-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR02924. ICDH_alpha. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_RICFE
AccessionPrimary (citable) accession number: Q4UKR1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 13, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names