Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q4UKR1 (IDH_RICFE)

Last modified June 16, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
Gene names
Name: icd
Ordered Locus Names: RF_1015
OrganismRickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier42862 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Hide | Top

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Oxalosuccinate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000292203

Sites

Metal binding2081Magnesium or manganese By similarity
Metal binding2321Magnesium or manganese By similarity
Metal binding2361Magnesium or manganese By similarity
Binding site891Substrate By similarity
Binding site991Substrate By similarity
Binding site1211Substrate By similarity
Binding site2081Substrate By similarity
Site1281Critical for catalysis By similarity
Site1751Critical for catalysis By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q4UKR1-1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 57322A4AD6884B3C

FASTA48354,062
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY TSGISEESWE 

        70         80         90        100        110        120 
SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP SVSFHPFTMT LHPHLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESIKLISHTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK 

       190        200        210        220        230        240 
FSDGVFHKIF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK ADYPLIAEKQ 

       370        380        390        400        410        420 
ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL DLGNIELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETISDH WCCRFMNKDG TEIKHLDITR LLEALSKANI DFIKVENLFE FDGVAGYSLA 


QGE

« Hide

Hide | Top

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Hide | Top

Cross-references

Sequence databases

CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqYP_247031.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3401026.
GenomeReviewsGene locus RF_1015 in contig CP000053_GR.
KEGGrfe:RF_1015.
NMPDRfig|315456.3.peg.1015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ4UKR1.
OMAQ4UKR1. DNIMKMT.

Enzyme and pathway databases

BioCycRFEL315456:RF_1015-MON.
BRENDA1.1.1.42. 297363.

Family and domain databases

InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_bac.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR02924. ICDH_alpha. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameIDH_RICFE
AccessionPrimary (citable) accession number: Q4UKR1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 16, 2009
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents