Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UKR1

- IDH_RICFE

UniProt

Q4UKR1 - IDH_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Sitei128 – 1281Critical for catalysisBy similarity
Sitei175 – 1751Critical for catalysisBy similarity
Metal bindingi208 – 2081Magnesium or manganeseBy similarity
Binding sitei208 – 2081SubstrateBy similarity
Metal bindingi232 – 2321Magnesium or manganeseBy similarity
Metal bindingi236 – 2361Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RF_1015
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000292203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1015.

Structurei

3D structure databases

ProteinModelPortaliQ4UKR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiMCMQLVM.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY
60 70 80 90 100
TSGISEESWE SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP
110 120 130 140 150
SVSFHPFTMT LHPHLNLTII RENEEDLYAG IEYRQTHNMY ESIKLISHTG
160 170 180 190 200
CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGVFHKIF NEIAKEYPQI
210 220 230 240 250
NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS
260 270 280 290 300
ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL
310 320 330 340 350
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK
360 370 380 390 400
ADYPLIAEKQ ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL
410 420 430 440 450
DLGNIELKTI SSKGLKLWPR DTRFETISDH WCCRFMNKDG TEIKHLDITR
460 470 480
LLEALSKANI DFIKVENLFE FDGVAGYSLA QGE
Length:483
Mass (Da):54,062
Last modified:June 26, 2007 - v2
Checksum:i57322A4AD6884B3C
GO

Sequence cautioni

The sequence AAY61866.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1. Different initiation.
RefSeqiYP_247031.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61866; AAY61866; RF_1015.
GeneIDi3401026.
KEGGirfe:RF_1015.
PATRICi17892797. VBIRicFel64634_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61866.1 . Different initiation.
RefSeqi YP_247031.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61866 ; AAY61866 ; RF_1015 .
GeneIDi 3401026.
KEGGi rfe:RF_1015.
PATRICi 17892797. VBIRicFel64634_1214.

Phylogenomic databases

eggNOGi COG0473.
HOGENOMi HOG000021113.
KOi K00031.
OMAi MCMQLVM.
OrthoDBi EOG65XN31.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1047-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiIDH_RICFE
AccessioniPrimary (citable) accession number: Q4UKR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 26, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3