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Q4UKQ6

- ODPA_RICFE

UniProt

Q4UKQ6 - ODPA_RICFE

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Protein
Pyruvate dehydrogenase E1 component subunit alpha
Gene
pdhA, RF_1020
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1052-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:RF_1020
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000288753Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi315456.RF_1020.

Structurei

3D structure databases

ProteinModelPortaliQ4UKQ6.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiEYAMGTS.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKQ6-1 [UniParc]FASTAAdd to Basket

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MDIKPKKYKP TKEEYIKSFK DMLLLRRFEE KCGQLYGMGE IGGFCHLYIG    50
QEAVISAVDT VKQKGDSTIT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS 100
KGKGGSMHLF DIPNKFYGGH GIVGAQVPIG TGLAFAEKYN GTNNICFTFL 150
GDGAVNQGQV YEAFNMAALW GLPVVYIIEN NEYSMGTSVA RSTFMRDLYK 200
KGESFGIKGF QLDGMDFEEM YNGAKQAAEY VRENSFPLIL EVKTYRYRGH 250
SMSDPAKYRS KEEVEQYKER DPLVIIRKTI LDNKYATEAD LKEIEQSVKE 300
IVKEAVKFSE NSPLPDEGEL YTEVYC 326
Length:326
Mass (Da):36,724
Last modified:July 5, 2005 - v1
Checksum:iDFD9E71813DC1E81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61871.1.
RefSeqiWP_011271336.1. NC_007109.1.
YP_247036.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61871; AAY61871; RF_1020.
GeneIDi3401031.
KEGGirfe:RF_1020.
PATRICi17892813. VBIRicFel64634_1222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61871.1 .
RefSeqi WP_011271336.1. NC_007109.1.
YP_247036.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKQ6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 315456.RF_1020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61871 ; AAY61871 ; RF_1020 .
GeneIDi 3401031.
KEGGi rfe:RF_1020.
PATRICi 17892813. VBIRicFel64634_1222.

Phylogenomic databases

eggNOGi COG1071.
HOGENOMi HOG000281336.
KOi K00161.
OMAi EYAMGTS.
OrthoDBi EOG6JMMWC.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1052-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiODPA_RICFE
AccessioniPrimary (citable) accession number: Q4UKQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names

External Data

Dasty 3

Similar proteinsi