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Q4UKQ2 (CTAA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme A synthase

Short name=HAS
EC=1.3.-.-
Alternative name(s):
Cytochrome aa3-controlling protein
Gene names
Name:ctaA
Synonyms:coxW
Ordered Locus Names:RF_1024
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group By similarity. HAMAP-Rule MF_01665

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. HAMAP-Rule MF_01665

Subunit structure

Interacts with CtaB By similarity. HAMAP-Rule MF_01665

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01665.

Sequence similarities

Belongs to the COX15/CtaA family. Type 2 subfamily.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme a biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity, acting on the CH-CH group of donors

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Heme A synthase HAMAP-Rule MF_01665
PRO_0000349076

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane285 – 30521Helical; Potential
Transmembrane308 – 32821Helical; Potential

Sites

Binding site3161Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UKQ2 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 60535EF3B04FF76F

FASTA33738,545
        10         20         30         40         50         60 
MQKSLITKWL FISCIMVIAM IVIGGITRLT GSGLSIVEWR PVTGILPPFS FESWQAEFAK 

        70         80         90        100        110        120 
YKAFPEYNSI NYGMTLSQFK FIYLLEFVHR LLGRITALIY IVPLIYFYFK DVIKNRDILP 

       130        140        150        160        170        180 
YIIALLLFCV QGFMGWYMVK SGLLNSPSVS HFRLAFHLII AVIIYHILFY QLIKNRCDIL 

       190        200        210        220        230        240 
LIPSQTDLKL PLIFSGIAIT VIYVQIFLGA MVAGLDAGLI YNSFPLMGDN FIPMEIKDNF 

       250        260        270        280        290        300 
FNLANLHDPV FIQFIHRLGG YSVFLVVVVL VICLLKIEHP KLNKIAYFLM IALLMQISTG 

       310        320        330 
IITLLYSVPI IIASIHQLFA IILLSIIIWC YFIIKTS 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61875.1.
RefSeqYP_247040.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61875; AAY61875; RF_1024.
GeneID3400134.
KEGGrfe:RF_1024.
PATRIC17892823. VBIRicFel64634_1227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1612.
HOGENOMHOG000214943.
KOK02259.
OMALSMVTWK.
OrthoDBEOG6KMB6V.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1056-MONOMER.
UniPathwayUPA00269; UER00713.

Family and domain databases

HAMAPMF_01665. HemeA_synth_type2.
InterProIPR003780. HemeA_syn.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamPF02628. COX15-CtaA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTAA_RICFE
AccessionPrimary (citable) accession number: Q4UKQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways