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Q4UKQ2

- CTAA_RICFE

UniProt

Q4UKQ2 - CTAA_RICFE

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Protein

Heme A synthase

Gene

ctaA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei316 – 3161SubstrateUniRule annotation

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

GO - Biological processi

  1. heme a biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1056-MONOMER.
UniPathwayiUPA00269; UER00713.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme A synthaseUniRule annotation (EC:1.3.-.-UniRule annotation)
Short name:
HASUniRule annotation
Alternative name(s):
Cytochrome aa3-controlling proteinUniRule annotation
Gene namesi
Name:ctaAUniRule annotation
Synonyms:coxW
Ordered Locus Names:RF_1024
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei118 – 13821HelicalUniRule annotationAdd
BLAST
Transmembranei154 – 17421HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21221HelicalUniRule annotationAdd
BLAST
Transmembranei258 – 27821HelicalUniRule annotationAdd
BLAST
Transmembranei285 – 30521HelicalUniRule annotationAdd
BLAST
Transmembranei308 – 32821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Heme A synthasePRO_0000349076Add
BLAST

Interactioni

Subunit structurei

Interacts with CtaB.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1024.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1612.
HOGENOMiHOG000214943.
KOiK02259.
OMAiLSMVTWK.
OrthoDBiEOG6KMB6V.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKSLITKWL FISCIMVIAM IVIGGITRLT GSGLSIVEWR PVTGILPPFS
60 70 80 90 100
FESWQAEFAK YKAFPEYNSI NYGMTLSQFK FIYLLEFVHR LLGRITALIY
110 120 130 140 150
IVPLIYFYFK DVIKNRDILP YIIALLLFCV QGFMGWYMVK SGLLNSPSVS
160 170 180 190 200
HFRLAFHLII AVIIYHILFY QLIKNRCDIL LIPSQTDLKL PLIFSGIAIT
210 220 230 240 250
VIYVQIFLGA MVAGLDAGLI YNSFPLMGDN FIPMEIKDNF FNLANLHDPV
260 270 280 290 300
FIQFIHRLGG YSVFLVVVVL VICLLKIEHP KLNKIAYFLM IALLMQISTG
310 320 330
IITLLYSVPI IIASIHQLFA IILLSIIIWC YFIIKTS
Length:337
Mass (Da):38,545
Last modified:July 5, 2005 - v1
Checksum:i60535EF3B04FF76F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61875.1.
RefSeqiYP_247040.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61875; AAY61875; RF_1024.
GeneIDi3400134.
KEGGirfe:RF_1024.
PATRICi17892823. VBIRicFel64634_1227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61875.1 .
RefSeqi YP_247040.1. NC_007109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61875 ; AAY61875 ; RF_1024 .
GeneIDi 3400134.
KEGGi rfe:RF_1024.
PATRICi 17892823. VBIRicFel64634_1227.

Phylogenomic databases

eggNOGi COG1612.
HOGENOMi HOG000214943.
KOi K02259.
OMAi LSMVTWK.
OrthoDBi EOG6KMB6V.

Enzyme and pathway databases

UniPathwayi UPA00269 ; UER00713 .
BioCyci RFEL315456:GKEK-1056-MONOMER.

Family and domain databases

HAMAPi MF_01665. HemeA_synth_type2.
InterProi IPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view ]
Pfami PF02628. COX15-CtaA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCTAA_RICFE
AccessioniPrimary (citable) accession number: Q4UKQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3