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Protein

Heme A synthase

Gene

ctaA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group.UniRule annotation

Pathwayi: heme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme A from heme O.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Heme A synthase (ctaA)
This subpathway is part of the pathway heme A biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme A from heme O, the pathway heme A biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00269; UER00713.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme A synthaseUniRule annotation (EC:1.3.-.-UniRule annotation)
Short name:
HASUniRule annotation
Alternative name(s):
Cytochrome aa3-controlling proteinUniRule annotation
Gene namesi
Name:ctaAUniRule annotation
Synonyms:coxW
Ordered Locus Names:RF_1024
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei285 – 305HelicalUniRule annotationAdd BLAST21
Transmembranei308 – 328HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003490761 – 337Heme A synthaseAdd BLAST337

Interactioni

Subunit structurei

Interacts with CtaB.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1024.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107TQK. Bacteria.
COG1612. LUCA.
HOGENOMiHOG000214943.
KOiK02259.
OMAiTALIYIV.
OrthoDBiPOG091H0M6V.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2. 1 hit.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSLITKWL FISCIMVIAM IVIGGITRLT GSGLSIVEWR PVTGILPPFS
60 70 80 90 100
FESWQAEFAK YKAFPEYNSI NYGMTLSQFK FIYLLEFVHR LLGRITALIY
110 120 130 140 150
IVPLIYFYFK DVIKNRDILP YIIALLLFCV QGFMGWYMVK SGLLNSPSVS
160 170 180 190 200
HFRLAFHLII AVIIYHILFY QLIKNRCDIL LIPSQTDLKL PLIFSGIAIT
210 220 230 240 250
VIYVQIFLGA MVAGLDAGLI YNSFPLMGDN FIPMEIKDNF FNLANLHDPV
260 270 280 290 300
FIQFIHRLGG YSVFLVVVVL VICLLKIEHP KLNKIAYFLM IALLMQISTG
310 320 330
IITLLYSVPI IIASIHQLFA IILLSIIIWC YFIIKTS
Length:337
Mass (Da):38,545
Last modified:July 5, 2005 - v1
Checksum:i60535EF3B04FF76F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61875.1.
RefSeqiWP_011271340.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61875; AAY61875; RF_1024.
KEGGirfe:RF_1024.
PATRICi17892823. VBIRicFel64634_1227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61875.1.
RefSeqiWP_011271340.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61875; AAY61875; RF_1024.
KEGGirfe:RF_1024.
PATRICi17892823. VBIRicFel64634_1227.

Phylogenomic databases

eggNOGiENOG4107TQK. Bacteria.
COG1612. LUCA.
HOGENOMiHOG000214943.
KOiK02259.
OMAiTALIYIV.
OrthoDBiPOG091H0M6V.

Enzyme and pathway databases

UniPathwayiUPA00269; UER00713.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2. 1 hit.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTAA_RICFE
AccessioniPrimary (citable) accession number: Q4UKQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.