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Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1060-MONOMER.
UniPathwayiUPA00359; UER00478.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylaseUniRule annotation
Gene namesi
Name:lpxCUniRule annotation
Ordered Locus Names:RF_1028
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191950Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1028.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiKAYKSGH.
OrthoDBiEOG6PGK74.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQSTLLKPV SCYGIGVHSG KRTQLTIEPA KENTGIIFIR TDISSENNYI
60 70 80 90 100
EASYFNVSDT LLSTTISNDH KVQISTIEHL MAALWGCSID NAIIKIDGPE
110 120 130 140 150
VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKDIKVVH KDCELYCTPY
160 170 180 190 200
DHMTVDLTID FASKAIGRQN LTFSKQESFN QNIADARTFG FTKELDYLQS
210 220 230 240 250
KGLAQGASFE NAIGIDEQDK ILNPNGLRYE DEFVRHKLLD LFGDLYTSGT
260 270 280
SVVSSIKGYK TSHALNNELL HRIFSDTTSY KFVTNSEL
Length:288
Mass (Da):32,231
Last modified:July 5, 2005 - v1
Checksum:i06174E7917E50CC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61879.1.
RefSeqiYP_247044.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61879; AAY61879; RF_1028.
KEGGirfe:RF_1028.
PATRICi17892834. VBIRicFel64634_1232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61879.1.
RefSeqiYP_247044.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61879; AAY61879; RF_1028.
KEGGirfe:RF_1028.
PATRICi17892834. VBIRicFel64634_1232.

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiKAYKSGH.
OrthoDBiEOG6PGK74.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00478.
BioCyciRFEL315456:GKEK-1060-MONOMER.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiLPXC_RICFE
AccessioniPrimary (citable) accession number: Q4UKP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.