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Q4UKP8 (LPXC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

EC=3.5.1.-
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene names
Name:lpxC
Ordered Locus Names:RF_1028
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388

Catalytic activity

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388

Sequence similarities

Belongs to the LpxC family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388
PRO_0000191950

Sequences

Sequence LengthMass (Da)Tools
Q4UKP8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 06174E7917E50CC1

FASTA28832,231
        10         20         30         40         50         60 
MQQSTLLKPV SCYGIGVHSG KRTQLTIEPA KENTGIIFIR TDISSENNYI EASYFNVSDT 

        70         80         90        100        110        120 
LLSTTISNDH KVQISTIEHL MAALWGCSID NAIIKIDGPE VPIMDGSSKP FVFMIECAGK 

       130        140        150        160        170        180 
KLQNAPKKYL KILKDIKVVH KDCELYCTPY DHMTVDLTID FASKAIGRQN LTFSKQESFN 

       190        200        210        220        230        240 
QNIADARTFG FTKELDYLQS KGLAQGASFE NAIGIDEQDK ILNPNGLRYE DEFVRHKLLD 

       250        260        270        280 
LFGDLYTSGT SVVSSIKGYK TSHALNNELL HRIFSDTTSY KFVTNSEL 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61879.1.
RefSeqYP_247044.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61879; AAY61879; RF_1028.
GeneID3400138.
KEGGrfe:RF_1028.
PATRIC17892834. VBIRicFel64634_1232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0774.
HOGENOMHOG000256664.
KOK02535.
OMAKAYKSGH.
OrthoDBEOG6PGK74.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1060-MONOMER.
UniPathwayUPA00359; UER00478.

Family and domain databases

Gene3D3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPMF_00388. LpxC.
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
TIGRFAMsTIGR00325. lpxC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXC_RICFE
AccessionPrimary (citable) accession number: Q4UKP8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways