Q4UKP8 (LPXC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	RF_1028

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388		PRO_0000191950

Sequences

	Sequence		Length	Mass (Da)
	Q4UKP8 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 06174E7917E50CC1	FASTA	288	32,231
	10 20 30 40 50 60 MQQSTLLKPV SCYGIGVHSG KRTQLTIEPA KENTGIIFIR TDISSENNYI EASYFNVSDT 70 80 90 100 110 120 LLSTTISNDH KVQISTIEHL MAALWGCSID NAIIKIDGPE VPIMDGSSKP FVFMIECAGK 130 140 150 160 170 180 KLQNAPKKYL KILKDIKVVH KDCELYCTPY DHMTVDLTID FASKAIGRQN LTFSKQESFN 190 200 210 220 230 240 QNIADARTFG FTKELDYLQS KGLAQGASFE NAIGIDEQDK ILNPNGLRYE DEFVRHKLLD 250 260 270 280 LFGDLYTSGT SVVSSIKGYK TSHALNNELL HRIFSDTTSY KFVTNSEL

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61879.1.
RefSeq	YP_247044.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UKP8.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1028.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61879; AAY61879; RF_1028.
GeneID	3400138.
KEGG	rfe:RF_1028.
PATRIC	17892834. VBIRicFel64634_1232.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HOG000256664.
KO	K02535.
OMA	KAYKSGH.
ProtClustDB	PRK13186.
Enzyme and pathway databases
UniPathway	UPA00359; UER00478.
Family and domain databases
Gene3D	3.30.1700.10. 1 hit. 3.30.230.20. 1 hit.
HAMAP	MF_00388. LpxC.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. lpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_RICFE

Accession

Primary (citable) accession number: Q4UKP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program