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Q4UKP8

- LPXC_RICFE

UniProt

Q4UKP8 - LPXC_RICFE

Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Source: InterPro

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1060-MONOMER.
    UniPathwayiUPA00359; UER00478.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
    Alternative name(s):
    UDP-3-O-acyl-GlcNAc deacetylaseUniRule annotation
    Gene namesi
    Name:lpxCUniRule annotation
    Ordered Locus Names:RF_1028
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191950Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1028.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0774.
    HOGENOMiHOG000256664.
    KOiK02535.
    OMAiKAYKSGH.
    OrthoDBiEOG6PGK74.

    Family and domain databases

    Gene3Di3.30.1700.10. 1 hit.
    3.30.230.20. 1 hit.
    HAMAPiMF_00388. LpxC.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR004463. UDP-acyl_GlcNac_deAcase.
    IPR011334. UDP-acyl_GlcNac_deAcase_C.
    IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
    [Graphical view]
    PfamiPF03331. LpxC. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    TIGRFAMsiTIGR00325. lpxC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UKP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQSTLLKPV SCYGIGVHSG KRTQLTIEPA KENTGIIFIR TDISSENNYI    50
    EASYFNVSDT LLSTTISNDH KVQISTIEHL MAALWGCSID NAIIKIDGPE 100
    VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKDIKVVH KDCELYCTPY 150
    DHMTVDLTID FASKAIGRQN LTFSKQESFN QNIADARTFG FTKELDYLQS 200
    KGLAQGASFE NAIGIDEQDK ILNPNGLRYE DEFVRHKLLD LFGDLYTSGT 250
    SVVSSIKGYK TSHALNNELL HRIFSDTTSY KFVTNSEL 288
    Length:288
    Mass (Da):32,231
    Last modified:July 5, 2005 - v1
    Checksum:i06174E7917E50CC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61879.1.
    RefSeqiYP_247044.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61879; AAY61879; RF_1028.
    GeneIDi3400138.
    KEGGirfe:RF_1028.
    PATRICi17892834. VBIRicFel64634_1232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61879.1 .
    RefSeqi YP_247044.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61879 ; AAY61879 ; RF_1028 .
    GeneIDi 3400138.
    KEGGi rfe:RF_1028.
    PATRICi 17892834. VBIRicFel64634_1232.

    Phylogenomic databases

    eggNOGi COG0774.
    HOGENOMi HOG000256664.
    KOi K02535.
    OMAi KAYKSGH.
    OrthoDBi EOG6PGK74.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00478 .
    BioCyci RFEL315456:GKEK-1060-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1700.10. 1 hit.
    3.30.230.20. 1 hit.
    HAMAPi MF_00388. LpxC.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR004463. UDP-acyl_GlcNac_deAcase.
    IPR011334. UDP-acyl_GlcNac_deAcase_C.
    IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
    [Graphical view ]
    Pfami PF03331. LpxC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    TIGRFAMsi TIGR00325. lpxC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiLPXC_RICFE
    AccessioniPrimary (citable) accession number: Q4UKP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3