Q4UKM7 (EFP_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor P
Short name=EF-P

Gene names

Name:	efp
Ordered Locus Names:	RF_1049

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase By similarity. HAMAP-Rule MF_00141
Pathway	Protein biosynthesis; polypeptide chain elongation. HAMAP-Rule MF_00141
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00141.
Sequence similarities	Belongs to the elongation factor P family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Elongation factor P HAMAP-Rule MF_00141		PRO_0000274854

Sequences

	Sequence		Length	Mass (Da)
	Q4UKM7 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: DB7DCFF8B8128CC0	FASTA	188	21,504
	10 20 30 40 50 60 MKISANSIRT GNILVYNNDL WVVSKTPEHT QPGKGGAYVQ VEMKNLKTGT KRNERFSSSD 70 80 90 100 110 120 YLEKAELEQK DYQFLYFEGD DLVLMDTKHF EQINVPKEIL EEKLPFLTEN MIVKVEFYNE 130 140 150 160 170 180 KPLNIELPPT VILEINETDP VIKGATATAS YKPAILENGI KVKVPQYLEV GEKIVVKTDD MTYVERAK

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61900.1.
RefSeq	YP_247065.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UKM7.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1049.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61900; AAY61900; RF_1049.
GeneID	3400159.
KEGG	rfe:RF_1049.
PATRIC	17892880. VBIRicFel64634_1255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0231.
HOGENOM	HOG000010048.
KO	K02356.
OMA	FMDNEDY.
ProtClustDB	PRK00529.
Enzyme and pathway databases
BioCyc	RFEL315456:GKEK-1081-MONOMER.
UniPathway	UPA00345.
Family and domain databases
Gene3D	2.30.30.30. 1 hit. 2.40.50.140. 2 hits.
HAMAP	MF_00141. EF-P.
InterPro	IPR015365. Elong-fact-P_C. IPR012340. NA-bd_OB-fold. IPR014722. Rib_L2_dom2. IPR020599. Transl_elong_fac_P/YeiP. IPR013185. Transl_elong_KOW-like. IPR001059. Transl_elong_P/YeiP_cen. IPR013852. Transl_elong_P/YeiP_CS. IPR011768. Transl_elongation_fac_P. IPR008991. Translation_prot_SH3-like. [Graphical view]
Pfam	PF01132. EFP. 1 hit. PF08207. EFP_N. 1 hit. PF09285. Elong-fact-P_C. 1 hit. [Graphical view]
PIRSF	PIRSF005901. EF-P. 1 hit.
SMART	SM00841. Elong-fact-P_C. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 2 hits. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR00038. efp. 1 hit.
PROSITE	PS01275. EFP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFP_RICFE

Accession

Primary (citable) accession number: Q4UKM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	July 5, 2005
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program