Reviewed, UniProtKB/Swiss-Prot Q4UKL7 (GLRX1_RICFE)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1

Gene names

Name:	grxC1
Synonyms:	grx
Ordered Locus Names:	RF_1059

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 102	102	Glutaredoxin-1		PRO_0000288736
Regions
	Domain	1 – 96	96	Glutaredoxin
Amino acid modifications
	Disulfide bond	17 ↔ 20		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UKL7-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: B94A5949CF6005F4	FASTA	102	11,396
	10 20 30 40 50 60 MNKAILHTII IYTLASCPYC IKAKALLDEK NVVYEEIEVS NFTQEEKEKF IKKSGGKKTV 70 80 90 100 PQIFIDNIHV GGCDALFDLE KEGRLDKLLE GQPKKKMPAA GA

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY61910.1.
RefSeq	YP_247075.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400169.
GenomeReviews	Gene locus RF_1059 in contig CP000053_GR.
KEGG	rfe:RF_1059.
NMPDR	fig|315456.3.peg.1059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UKL7.
OMA	Q4UKL7. CDELHAL.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_1059-MON.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011900. GRX_bact. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02181. GRX_bact. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_RICFE

Accession

Primary (citable) accession number: Q4UKL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)