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Protein

Probable cytochrome c oxidase subunit 3

Gene

ctaE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Gene namesi
Name:ctaE
Synonyms:coxC
Ordered Locus Names:RF_1076
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Probable cytochrome c oxidase subunit 3PRO_0000280890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1076.

Structurei

3D structure databases

ProteinModelPortaliQ4UKK0.
SMRiQ4UKK0. Positions 9-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
KOiK02276.
OMAiGFFWAFY.
OrthoDBiEOG6V7BK2.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPNSHPITK SHLFHIVDPS PWPVLTSFAL LLLVIGGVSF MHGYKFNIYI
60 70 80 90 100
LSAGVISVGY CLYSWWRDVV KEGIVEHQHT SPVRKGLQIG MALFILTEIV
110 120 130 140 150
FFGVFFASFF KSSLSPVGLL DGVWVVKQGI WPPPTIKTFD PFDIPFINTL
160 170 180 190 200
ILLLSGTTVT WAHYALEEKN QKDCVTALAL TILLGIFFTT MQAYEYYHAA
210 220 230 240 250
FKFTDGIYAS NFYLATGFHG AHVIIGTIFL IVCYFRAKRG DFTTEGNGHL
260 270
GFEFAAWYWH FVDVVWLFLF TFVYIFGS
Length:278
Mass (Da):31,505
Last modified:July 5, 2005 - v1
Checksum:i7CF5B3F4E7BDCAB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61927.1.
RefSeqiYP_247092.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61927; AAY61927; RF_1076.
KEGGirfe:RF_1076.
PATRICi17892954. VBIRicFel64634_1292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61927.1.
RefSeqiYP_247092.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UKK0.
SMRiQ4UKK0. Positions 9-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1076.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61927; AAY61927; RF_1076.
KEGGirfe:RF_1076.
PATRICi17892954. VBIRicFel64634_1292.

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
KOiK02276.
OMAiGFFWAFY.
OrthoDBiEOG6V7BK2.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1108-MONOMER.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCOX3_RICFE
AccessioniPrimary (citable) accession number: Q4UKK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.