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Q4UKI8

- ODO1_RICFE

UniProt

Q4UKI8 - ODO1_RICFE

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1124-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RF_1092
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9779772-oxoglutarate dehydrogenase E1 componentPRO_0000288750Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi315456.RF_1092.

Structurei

3D structure databases

ProteinModelPortaliQ4UKI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 12549RPE1 insertAdd
BLAST

Sequence similaritiesi

Contains 1 RPE1 insert domain.Curated

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005728. Rickett_RPE.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
TIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEDLKKTGY LFGGNAVFVD ELYRQYLANP ASVDQTWQEF FAGIKDNSTV
60 70 80 90 100
LNKSTAKIII PYEIKKEPLN NNLSSEVLNN RHLAKPAYRE EFKGDTERST
110 120 130 140 150
AAYIDIREDA STGSTSKLPL EAKFGKMSSL KAKEMINTYR KHAHYLANLD
160 170 180 190 200
PLGLELRKTK NDLKLNIETF GLDNSQLEKN INITDEFVGN WNCKLSELVT
210 220 230 240 250
KLDKTYTGSI GVEFEQIENV EEKNWLYNKL ESEVTFSSED KKTILNDLVE
260 270 280 290 300
VEGFEQYLHT KFPGAKRFSV EGGDASIVAM SKAIDLSMNQ GVEEIVIGMA
310 320 330 340 350
HRGRLNTLTK VVGKPYKAVI AGFISGSVFP DELNVSGDVK YHLGYSSDRT
360 370 380 390 400
IDNKKIHLSL ADNPSHLEAV NPIVAGKVRA KQDILGDTKR SKVKAILVHG
410 420 430 440 450
DAAFCGQGVV AESLSMSPLA AYDIGGILHF VINNQLGFTA NAADTRASRY
460 470 480 490 500
STEFAKIIAA PILHVNGDDI EAVLKATNIA VEYRQKFGKD VVVEIICYRK
510 520 530 540 550
YGHNEGDEPM YTQGKMYNII KSKPTPGNIY ANELVKSGII DNNYFAKLKE
560 570 580 590 600
EFKAKLDKEF EQAKNYKPEA HFLGGLWQGI SRIRTQAAIT GVGKKTLQDL
610 620 630 640 650
GTKLCEIPKD FAVNPKLVKL FEARKATLTS DQPIDWATAE QLAFASLLSE
660 670 680 690 700
GTNIRLTGQD CGRGTFSHRH SVLHNQIDDT TYIPLNNLSK TQAKYEVADS
710 720 730 740 750
NLSEYAVLGF EYGYSLANPK NLVLWEAQFG DFANGAQIIF DQFISSSETK
760 770 780 790 800
WLRMSGLVVL LPHAFEGQGP EHSSARLERF LQLAAEDNMY VTYPTTPASI
810 820 830 840 850
FHLLRRQILD DTRKPLIIMS PKSLLRHKYA VSKLDELGEN TTFLPVLDEV
860 870 880 890 900
NKVDTNNITK VILCSGKVYY DLFEMRGNNS NIAIIRLEQL YPFEKKLVAS
910 920 930 940 950
LLKKYNRTQE FIWCQEEPKN MGAWRYIVSH LNDVLKEAGI NNEFKYVGRE
960 970
ESASPAVGSL QAHNKQQEKL LKEALGM
Length:977
Mass (Da):109,496
Last modified:May 29, 2007 - v2
Checksum:iB0B3FAD38BA0533F
GO

Sequence cautioni

The sequence AAY61943.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61943.1. Different initiation.
RefSeqiYP_247108.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61943; AAY61943; RF_1092.
GeneIDi3400202.
KEGGirfe:RF_1092.
PATRICi17892996. VBIRicFel64634_1313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61943.1 . Different initiation.
RefSeqi YP_247108.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61943 ; AAY61943 ; RF_1092 .
GeneIDi 3400202.
KEGGi rfe:RF_1092.
PATRICi 17892996. VBIRicFel64634_1313.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1124-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005728. Rickett_RPE.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
TIGR01045. RPE1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiODO1_RICFE
AccessioniPrimary (citable) accession number: Q4UKI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3