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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RF_1092
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887501 – 9772-oxoglutarate dehydrogenase E1 componentAdd BLAST977

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi315456.RF_1092.

Structurei

3D structure databases

ProteinModelPortaliQ4UKI8.
SMRiQ4UKI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 125RPE1 insertAdd BLAST49

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C7P. Bacteria.
COG0567. LUCA.
HOGENOMiHOG000259588.
KOiK00164.
OrthoDBiPOG091H03SK.

Family and domain databases

InterProiView protein in InterPro
IPR032106. 2-oxogl_dehyd_N.
IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR005728. Rickett_RPE.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiView protein in Pfam
PF16078. 2-oxogl_dehyd_N. 1 hit.
PF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
TIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UKI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDLKKTGY LFGGNAVFVD ELYRQYLANP ASVDQTWQEF FAGIKDNSTV
60 70 80 90 100
LNKSTAKIII PYEIKKEPLN NNLSSEVLNN RHLAKPAYRE EFKGDTERST
110 120 130 140 150
AAYIDIREDA STGSTSKLPL EAKFGKMSSL KAKEMINTYR KHAHYLANLD
160 170 180 190 200
PLGLELRKTK NDLKLNIETF GLDNSQLEKN INITDEFVGN WNCKLSELVT
210 220 230 240 250
KLDKTYTGSI GVEFEQIENV EEKNWLYNKL ESEVTFSSED KKTILNDLVE
260 270 280 290 300
VEGFEQYLHT KFPGAKRFSV EGGDASIVAM SKAIDLSMNQ GVEEIVIGMA
310 320 330 340 350
HRGRLNTLTK VVGKPYKAVI AGFISGSVFP DELNVSGDVK YHLGYSSDRT
360 370 380 390 400
IDNKKIHLSL ADNPSHLEAV NPIVAGKVRA KQDILGDTKR SKVKAILVHG
410 420 430 440 450
DAAFCGQGVV AESLSMSPLA AYDIGGILHF VINNQLGFTA NAADTRASRY
460 470 480 490 500
STEFAKIIAA PILHVNGDDI EAVLKATNIA VEYRQKFGKD VVVEIICYRK
510 520 530 540 550
YGHNEGDEPM YTQGKMYNII KSKPTPGNIY ANELVKSGII DNNYFAKLKE
560 570 580 590 600
EFKAKLDKEF EQAKNYKPEA HFLGGLWQGI SRIRTQAAIT GVGKKTLQDL
610 620 630 640 650
GTKLCEIPKD FAVNPKLVKL FEARKATLTS DQPIDWATAE QLAFASLLSE
660 670 680 690 700
GTNIRLTGQD CGRGTFSHRH SVLHNQIDDT TYIPLNNLSK TQAKYEVADS
710 720 730 740 750
NLSEYAVLGF EYGYSLANPK NLVLWEAQFG DFANGAQIIF DQFISSSETK
760 770 780 790 800
WLRMSGLVVL LPHAFEGQGP EHSSARLERF LQLAAEDNMY VTYPTTPASI
810 820 830 840 850
FHLLRRQILD DTRKPLIIMS PKSLLRHKYA VSKLDELGEN TTFLPVLDEV
860 870 880 890 900
NKVDTNNITK VILCSGKVYY DLFEMRGNNS NIAIIRLEQL YPFEKKLVAS
910 920 930 940 950
LLKKYNRTQE FIWCQEEPKN MGAWRYIVSH LNDVLKEAGI NNEFKYVGRE
960 970
ESASPAVGSL QAHNKQQEKL LKEALGM
Length:977
Mass (Da):109,496
Last modified:May 29, 2007 - v2
Checksum:iB0B3FAD38BA0533F
GO

Sequence cautioni

The sequence AAY61943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61943.1. Different initiation.
RefSeqiWP_041405326.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61943; AAY61943; RF_1092.
KEGGirfe:RF_1092.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiODO1_RICFE
AccessioniPrimary (citable) accession number: Q4UKI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 7, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families