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Q4UKI8 (ODO1_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:RF_1092
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length977 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Contains 1 RPE1 insert domain.

Sequence caution

The sequence AAY61943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9779772-oxoglutarate dehydrogenase E1 component
PRO_0000288750

Regions

Domain77 – 12549RPE1 insert

Sequences

Sequence LengthMass (Da)Tools
Q4UKI8 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: B0B3FAD38BA0533F

FASTA977109,496
        10         20         30         40         50         60 
MEEDLKKTGY LFGGNAVFVD ELYRQYLANP ASVDQTWQEF FAGIKDNSTV LNKSTAKIII 

        70         80         90        100        110        120 
PYEIKKEPLN NNLSSEVLNN RHLAKPAYRE EFKGDTERST AAYIDIREDA STGSTSKLPL 

       130        140        150        160        170        180 
EAKFGKMSSL KAKEMINTYR KHAHYLANLD PLGLELRKTK NDLKLNIETF GLDNSQLEKN 

       190        200        210        220        230        240 
INITDEFVGN WNCKLSELVT KLDKTYTGSI GVEFEQIENV EEKNWLYNKL ESEVTFSSED 

       250        260        270        280        290        300 
KKTILNDLVE VEGFEQYLHT KFPGAKRFSV EGGDASIVAM SKAIDLSMNQ GVEEIVIGMA 

       310        320        330        340        350        360 
HRGRLNTLTK VVGKPYKAVI AGFISGSVFP DELNVSGDVK YHLGYSSDRT IDNKKIHLSL 

       370        380        390        400        410        420 
ADNPSHLEAV NPIVAGKVRA KQDILGDTKR SKVKAILVHG DAAFCGQGVV AESLSMSPLA 

       430        440        450        460        470        480 
AYDIGGILHF VINNQLGFTA NAADTRASRY STEFAKIIAA PILHVNGDDI EAVLKATNIA 

       490        500        510        520        530        540 
VEYRQKFGKD VVVEIICYRK YGHNEGDEPM YTQGKMYNII KSKPTPGNIY ANELVKSGII 

       550        560        570        580        590        600 
DNNYFAKLKE EFKAKLDKEF EQAKNYKPEA HFLGGLWQGI SRIRTQAAIT GVGKKTLQDL 

       610        620        630        640        650        660 
GTKLCEIPKD FAVNPKLVKL FEARKATLTS DQPIDWATAE QLAFASLLSE GTNIRLTGQD 

       670        680        690        700        710        720 
CGRGTFSHRH SVLHNQIDDT TYIPLNNLSK TQAKYEVADS NLSEYAVLGF EYGYSLANPK 

       730        740        750        760        770        780 
NLVLWEAQFG DFANGAQIIF DQFISSSETK WLRMSGLVVL LPHAFEGQGP EHSSARLERF 

       790        800        810        820        830        840 
LQLAAEDNMY VTYPTTPASI FHLLRRQILD DTRKPLIIMS PKSLLRHKYA VSKLDELGEN 

       850        860        870        880        890        900 
TTFLPVLDEV NKVDTNNITK VILCSGKVYY DLFEMRGNNS NIAIIRLEQL YPFEKKLVAS 

       910        920        930        940        950        960 
LLKKYNRTQE FIWCQEEPKN MGAWRYIVSH LNDVLKEAGI NNEFKYVGRE ESASPAVGSL 

       970 
QAHNKQQEKL LKEALGM 

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61943.1. Different initiation.
RefSeqYP_247108.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61943; AAY61943; RF_1092.
GeneID3400202.
KEGGrfe:RF_1092.
PATRIC17892996. VBIRicFel64634_1313.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1124-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005728. Rickett_RPE.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
TIGR01045. RPE1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_RICFE
AccessionPrimary (citable) accession number: Q4UKI8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 11, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names