Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4UKI8

- ODO1_RICFE

UniProt

Q4UKI8 - ODO1_RICFE

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1124-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:sucA
    Ordered Locus Names:RF_1092
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9779772-oxoglutarate dehydrogenase E1 componentPRO_0000288750Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_1092.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 12549RPE1 insertAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RPE1 insert domain.Curated

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR005728. Rickett_RPE.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
    TIGR01045. RPE1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UKI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEDLKKTGY LFGGNAVFVD ELYRQYLANP ASVDQTWQEF FAGIKDNSTV    50
    LNKSTAKIII PYEIKKEPLN NNLSSEVLNN RHLAKPAYRE EFKGDTERST 100
    AAYIDIREDA STGSTSKLPL EAKFGKMSSL KAKEMINTYR KHAHYLANLD 150
    PLGLELRKTK NDLKLNIETF GLDNSQLEKN INITDEFVGN WNCKLSELVT 200
    KLDKTYTGSI GVEFEQIENV EEKNWLYNKL ESEVTFSSED KKTILNDLVE 250
    VEGFEQYLHT KFPGAKRFSV EGGDASIVAM SKAIDLSMNQ GVEEIVIGMA 300
    HRGRLNTLTK VVGKPYKAVI AGFISGSVFP DELNVSGDVK YHLGYSSDRT 350
    IDNKKIHLSL ADNPSHLEAV NPIVAGKVRA KQDILGDTKR SKVKAILVHG 400
    DAAFCGQGVV AESLSMSPLA AYDIGGILHF VINNQLGFTA NAADTRASRY 450
    STEFAKIIAA PILHVNGDDI EAVLKATNIA VEYRQKFGKD VVVEIICYRK 500
    YGHNEGDEPM YTQGKMYNII KSKPTPGNIY ANELVKSGII DNNYFAKLKE 550
    EFKAKLDKEF EQAKNYKPEA HFLGGLWQGI SRIRTQAAIT GVGKKTLQDL 600
    GTKLCEIPKD FAVNPKLVKL FEARKATLTS DQPIDWATAE QLAFASLLSE 650
    GTNIRLTGQD CGRGTFSHRH SVLHNQIDDT TYIPLNNLSK TQAKYEVADS 700
    NLSEYAVLGF EYGYSLANPK NLVLWEAQFG DFANGAQIIF DQFISSSETK 750
    WLRMSGLVVL LPHAFEGQGP EHSSARLERF LQLAAEDNMY VTYPTTPASI 800
    FHLLRRQILD DTRKPLIIMS PKSLLRHKYA VSKLDELGEN TTFLPVLDEV 850
    NKVDTNNITK VILCSGKVYY DLFEMRGNNS NIAIIRLEQL YPFEKKLVAS 900
    LLKKYNRTQE FIWCQEEPKN MGAWRYIVSH LNDVLKEAGI NNEFKYVGRE 950
    ESASPAVGSL QAHNKQQEKL LKEALGM 977
    Length:977
    Mass (Da):109,496
    Last modified:May 29, 2007 - v2
    Checksum:iB0B3FAD38BA0533F
    GO

    Sequence cautioni

    The sequence AAY61943.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61943.1. Different initiation.
    RefSeqiYP_247108.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61943; AAY61943; RF_1092.
    GeneIDi3400202.
    KEGGirfe:RF_1092.
    PATRICi17892996. VBIRicFel64634_1313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61943.1 . Different initiation.
    RefSeqi YP_247108.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61943 ; AAY61943 ; RF_1092 .
    GeneIDi 3400202.
    KEGGi rfe:RF_1092.
    PATRICi 17892996. VBIRicFel64634_1313.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1124-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR005728. Rickett_RPE.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    TIGR01045. RPE1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiODO1_RICFE
    AccessioniPrimary (citable) accession number: Q4UKI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3