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Protein

Ribosomal RNA large subunit methyltransferase E

Gene

rlmE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei80S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei103S-adenosyl-L-methionineUniRule annotation1
Binding sitei119S-adenosyl-L-methionineUniRule annotation1
Binding sitei143S-adenosyl-L-methionineUniRule annotation1
Active sitei183Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase EUniRule annotation (EC:2.1.1.166UniRule annotation)
Alternative name(s):
23S rRNA Um2552 methyltransferaseUniRule annotation
rRNA (uridine-2'-O-)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmEUniRule annotation
Synonyms:ftsJUniRule annotation, rrmJUniRule annotation
Ordered Locus Names:RF_1118
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001555331 – 227Ribosomal RNA large subunit methyltransferase EAdd BLAST227

Proteomic databases

PRIDEiQ4UKG2

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1118

Structurei

3D structure databases

ProteinModelPortaliQ4UKG2
SMRiQ4UKG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F7M Bacteria
COG0293 LUCA
HOGENOMiHOG000162367
KOiK02427
OMAiHRQTDHL
OrthoDBiPOG091H05ST

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01728 FtsJ, 1 hit
PIRSFiPIRSF005461 23S_rRNA_mtase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q4UKG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNLSGYRN KFVRVKTSKK RTVSSSNWLR RQLNDPYVAK ARLEGFRSRA
60 70 80 90 100
AYKLLEIHGK FKLFNPNMKI VDLGAAPGGW SQVASKLIKA SDNSLNNKII
110 120 130 140 150
SIDLLEIEPI AEVEFFQKDF FEENTEELII QALDGKADIV MSDMASNTIG
160 170 180 190 200
HKATDHIRTL LLCEQAFEFA LKVLKPSGHF IAKIFRGGAE NELLNKVKRE
210 220
FRTVKHFKPS SSRSESTEIY LVALNKK
Length:227
Mass (Da):25,764
Last modified:July 5, 2005 - v1
Checksum:iA7528B1C4DC19D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61969.1
RefSeqiWP_011271428.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61969; AAY61969; RF_1118
KEGGirfe:RF_1118

Similar proteinsi

Entry informationi

Entry nameiRLME_RICFE
AccessioniPrimary (citable) accession number: Q4UKG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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