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Q4UKF1

- GATA_RICFE

UniProt

Q4UKF1 - GATA_RICFE

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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Charge relay systemUniRule annotation
Active sitei158 – 1581Charge relay systemUniRule annotation
Active sitei182 – 1821Acyl-ester intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-ADT subunit AUniRule annotation
Gene namesi
Name:gatAUniRule annotation
Ordered Locus Names:RF_1129
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000241149Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1129.

Structurei

3D structure databases

ProteinModelPortaliQ4UKF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0154.
HOGENOMiHOG000116699.
KOiK02433.
OMAiYDILLAY.
OrthoDBiEOG61P6R9.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELNKLTVA DSVKGLKNKD FTSKELVNAH IKQIEKHKNL NAYVTETFDL
60 70 80 90 100
ALKQAEAADQ NYAQNQPQTL EGIPFAAKDL FCTKGIRTTA CSNILKNFIP
110 120 130 140 150
NYESSVTQNI FDKGGVMLGK TNMDEFAMGS ANITSCFGNV ISPWKANDDN
160 170 180 190 200
ADLVPGGSSG GSAAAVSGFM ASAALGSDTG GSVRQPASFT GLVGFKPTYG
210 220 230 240 250
RCSRYGMVSF ASSLDQAGIF TRSVLDSSIM LEAMMGFDEK DSTSIKAEVP
260 270 280 290 300
ELQSAIGSSM KNMKIGVPLS LGEGGIIEPD IMKMWQDTIE LLKNAGAEIV
310 320 330 340 350
DITLPHAKYG VAVYYVIAPA EASSNLSRYD GVRYGLRVER ENMTLDEMYE
360 370 380 390 400
MTRSAGFGEE VKRRIMIGTY VLSSSCMDAY YLKAQKVRRL VANDFNNAFA
410 420 430 440 450
KVDAILLPAA PTEAFKIGEK QNDPTIMYLN DLFTIPASLA GLPCASVPAG
460 470 480 490
LSARGLPLGM QIIGKQLDEY NVLKVASTIE SGVKHIKFEP KGF
Length:493
Mass (Da):53,180
Last modified:July 5, 2005 - v1
Checksum:i1BA841879A33C182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61980.1.
RefSeqiYP_247145.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61980; AAY61980; RF_1129.
GeneIDi3401426.
KEGGirfe:RF_1129.
PATRICi17893100. VBIRicFel64634_1364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61980.1 .
RefSeqi YP_247145.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61980 ; AAY61980 ; RF_1129 .
GeneIDi 3401426.
KEGGi rfe:RF_1129.
PATRICi 17893100. VBIRicFel64634_1364.

Phylogenomic databases

eggNOGi COG0154.
HOGENOMi HOG000116699.
KOi K02433.
OMAi YDILLAY.
OrthoDBi EOG61P6R9.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1162-MONOMER.

Family and domain databases

Gene3Di 3.90.1300.10. 1 hit.
HAMAPi MF_00120. GatA.
InterProi IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view ]
PANTHERi PTHR11895. PTHR11895. 1 hit.
Pfami PF01425. Amidase. 1 hit.
[Graphical view ]
SUPFAMi SSF75304. SSF75304. 1 hit.
TIGRFAMsi TIGR00132. gatA. 1 hit.
PROSITEi PS00571. AMIDASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiGATA_RICFE
AccessioniPrimary (citable) accession number: Q4UKF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3