Q4UKD5 (RPOC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta'
Short name=RNAP subunit beta'
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'

Gene names

Name:	rpoC
Ordered Locus Names:	RF_1145

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	1372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01322
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01322
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta' chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1372	1372	DNA-directed RNA polymerase subunit beta' HAMAP-Rule MF_01322		PRO_0000225573

Sequences

	Sequence		Length	Mass (Da)
	Q4UKD5 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 864E04C0B485E8CB	FASTA	1,372	153,405
	10 20 30 40 50 60 MSVVNFYGQL SNTQQFDQIR INIASPDQVR SWSFGEVTKP ETINYRTFKP EKDGLFCARI 70 80 90 100 110 120 FGPVKDYECL CGKYKRMKNR GITCEKCGVE VTVSRVRRER MGHIELAAPV AHIWFLKSLP 130 140 150 160 170 180 SRISTLLDMT MRDVEKILYF ENYVVVDPGL SILQKGELLT EEELQKAKDK YGEDAFTASI 190 200 210 220 230 240 GAEVIQQMLK EIDFLKLKQE LYEELQTTSS EVKKKKLVKR LKLVEDFLES ENKPEWMIMD 250 260 270 280 290 300 VLPVIPPEIR PLVMLDGGRF ATSDLNELYR RVINRNNRLK KLIESKAPDI IVRNEKRMLQ 310 320 330 340 350 360 EAVDALFDNG RRGRAAKNAN KRPFKSLSDM LKGKQGRFRQ NLLGKRVDYS GRSVIVVGSE 370 380 390 400 410 420 LKLHQCGLPK KMALELFKPF IYSKLELYGI ATTIKAAKRM VEAEKPEVWD VLEEVIREHP 430 440 450 460 470 480 VLLNRAPTLH RLGIQAFEPL LIEGKAIQLY PLVCAAFNAD FDGDQMAVHI PLSIEAQLEA 490 500 510 520 530 540 RVFMMSTNNI LSPANGRPII VPDKDIVLGL YYLTLAFDNE VGEGMMFSDL AEMEHALYNK 550 560 570 580 590 600 FITIHTKIKY RRNQLNAEGK MVPVIIDTTY GRLMVGELLP SNPNIEFKFI NKQLTKKDIS 610 620 630 640 650 660 LVIDLVYRHC GQKATVIFAD QLMKLGFKYA CSSGISFGMD DMVVPESKST HINETQLEIK 670 680 690 700 710 720 EFEQQYSNGL ITYGEKYNKV VDAWSRCTDR VANDMMKEIA TPPVSDDPNH QKINAIYMMA 730 740 750 760 770 780 ISGARGSFQQ IKQLGGMRGL MTKSNGQIIQ TPIISNFKEG LTEFECFNSA NGMRKGQIDT 790 800 810 820 830 840 ALKTASSGYL TRKLVDVAQD CIITEKDCGT DKGIEVKSVI EGGEVIVPLA EKILGRTAAI 850 860 870 880 890 900 DIFHPVTNDL ILNKGELINE AKLEQIESAG LDRIMIKSVL TCESTTGICS ICYGRDLATG 910 920 930 940 950 960 TLVSEGEAIG VIAAQSIGEP GTQLTMRTFH IGGAATKGAE VSSVEASYDA KVKIISRNVV 970 980 990 1000 1010 1020 INSEERKIVM SRNCELLLLD NNGNEKARHK IPYGARLLVD DGDMVIKTQK LAEWDPYTIP 1030 1040 1050 1060 1070 1080 IITEKSGKVL FKDMVEGISI RDVTDEATGI PSKVIIESKQ YSRGAELRPR IQLLDAKGEV 1090 1100 1110 1120 1130 1140 IALSNGLEAR YYLPVGAVLS VEDGVQISVG DIIARIPKES TTTKDITGGL PRVAELVEAR 1150 1160 1170 1180 1190 1200 RPKDHAVIAE IDGRVEFGKD YKSKRRIIIH PIDETMSIEY MVPKGKHVVV NEGDFVKKGD 1210 1220 1230 1240 1250 1260 LLIDGNPVLQ DILKVMGVEV LANYIVKEVQ AVYRLQGVKI DDKHIEVIIR QMLQKVEITD 1270 1280 1290 1300 1310 1320 SGGTTLLAGE KIDRHEFEEI NEKAIKNGLK PAEAQLILQG ITKASLQTRS FISAASFQET 1330 1340 1350 1360 1370 TRVLTEAAIA GKIDKLRGLK ENVIVGRLVP AGTGYFMDKM RKAAVKLDEE NV

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61996.1.
RefSeq	YP_247161.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UKD5.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1145.
Proteomic databases
PRIDE	Q4UKD5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61996; AAY61996; RF_1145.
GeneID	3401442.
KEGG	rfe:RF_1145.
PATRIC	17893134. VBIRicFel64634_1381.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0086.
HOGENOM	HOG000218386.
KO	K03046.
OMA	DINDKHI.
ProtClustDB	PRK00566.
Family and domain databases
Gene3D	2.40.40.20. 2 hits.
HAMAP	MF_01322. RNApol_bact_RpoC.
InterPro	IPR009010. Asp_de-COase-like_dom. IPR012754. DNA-dir_RpoC_beta_prime. IPR000722. RNA_pol_asu. IPR006592. RNA_pol_N. IPR007080. RNA_pol_Rpb1_1. IPR007066. RNA_pol_Rpb1_3. IPR007083. RNA_pol_Rpb1_4. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
Pfam	PF04997. RNA_pol_Rpb1_1. 1 hit. PF00623. RNA_pol_Rpb1_2. 1 hit. PF04983. RNA_pol_Rpb1_3. 1 hit. PF05000. RNA_pol_Rpb1_4. 1 hit. PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
SMART	SM00663. RPOLA_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02386. rpoC_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPOC_RICFE

Accession

Primary (citable) accession number: Q4UKD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program