Q4UKC1 (DHSC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase cytochrome b556 subunit
Short name=Cytochrome b-556

Gene names

Name:	sdhC
Ordered Locus Names:	RF_1163

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome b560 family.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell succinate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Succinate dehydrogenase cytochrome b556 subunit		PRO_0000281051
Regions
	Topological domain	1 – 29	29	Cytoplasmic By similarity
	Transmembrane	30 – 55	26	Helical; By similarity
	Topological domain	56 – 67	12	Periplasmic By similarity
	Transmembrane	68 – 88	21	Helical; By similarity
	Topological domain	89 – 103	15	Cytoplasmic By similarity
	Transmembrane	104 – 124	21	Helical; By similarity
Sites
	Metal binding	83	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UKC1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: A756A3E50CE104D3	FASTA	124	14,358
	10 20 30 40 50 60 MTKTKQEIYN KRPTSPHLSI YKLQISSTLS ILHRMTGVAL FFAVSILAWW LILSKYDNNY 70 80 90 100 110 120 LQFANCCIIK ICLVAVSYAW FYHLCNGIRH LFWDIGYGFS IKAVNITGWC VVVCSILLTM LLWV

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY62014.1.
RefSeq	YP_247179.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 1NEK based on UniProtKB P69054.
ProteinModelPortal	Q4UKC1.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1163.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY62014; AAY62014; RF_1163.
GeneID	3401461.
KEGG	rfe:RF_1163.
PATRIC	17893174. VBIRicFel64634_1400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2009.
HOGENOM	HOG000160253.
KO	K00241.
OMA	WALMHHM.
ProtClustDB	CLSK870757.
Enzyme and pathway databases
UniPathway	UPA00223.
Family and domain databases
InterPro	IPR018495. Succ_DH_cyt_bsu_CS. IPR014314. Succ_DH_cytb556. IPR014361. Succ_DH_cytb560. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
PIRSF	PIRSF000178. SDH_cyt_b560. 1 hit.
TIGRFAMs	TIGR02970. succ_dehyd_cytB. 1 hit.
PROSITE	PS01000. SDH_CYT_1. 1 hit. PS01001. SDH_CYT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSC_RICFE

Accession

Primary (citable) accession number: Q4UKC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program