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Q4UKB0

- ERA_RICFE

UniProt

Q4UKB0 - ERA_RICFE

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Protein
GTPase Era
Gene
era, RF_1174
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTP Reviewed prediction
Nucleotide bindingi60 – 645GTP Reviewed prediction
Nucleotide bindingi122 – 1254GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: UniProtKB-HAMAP
  3. small ribosomal subunit rRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. ribosomal small subunit biogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase Era
Gene namesi
Name:era
Ordered Locus Names:RF_1174
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293GTPase EraUniRule annotation
PRO_0000277965Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1174.

Structurei

3D structure databases

ProteinModelPortaliQ4UKB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 174170Era-type G
Add
BLAST
Domaini202 – 27978KH type-2
Add
BLAST

Sequence similaritiesi

Contains 1 KH type-2 domain.

Phylogenomic databases

eggNOGiCOG1159.
HOGENOMiHOG000245597.
KOiK03595.
OMAiHDNAQIV.
OrthoDBiEOG68DD1Q.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00367. GTPase_Era.
InterProiIPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00436. era. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKB0-1 [UniParc]FASTAAdd to Basket

« Hide

MTKQKTISFC IIGRPNSGKS TLLNRIIGEK LSIVTPKVQT TRSIITGIIT    50
LKDTQVILYD TPGIFEPKGT LEKAMVRCAW SSLHSADLVM LIIDSLKPFD 100
DVMHDILDKL RSLNIVPIFL LNKIDIESKY LDDIKAFLTE NHPDSLLFPI 150
SALSGKNIDG LLEYITGKAK ISPWLYAEDD ITDLPMRFIA AEITREQLFF 200
NLQQELPYKL TVQTEKWEVL KDKSIKINQV IVVSRESYKT IILGKNGSKI 250
KEIGAKSRMQ MERFFGFPVH LFLFVKVREL WENNQEFYQY MKI 293
Length:293
Mass (Da):33,694
Last modified:July 5, 2005 - v1
Checksum:i82D1B619DA0DEE00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62025.1.
RefSeqiWP_011271482.1. NC_007109.1.
YP_247190.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62025; AAY62025; RF_1174.
GeneIDi3401472.
KEGGirfe:RF_1174.
PATRICi17893202. VBIRicFel64634_1414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62025.1 .
RefSeqi WP_011271482.1. NC_007109.1.
YP_247190.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62025 ; AAY62025 ; RF_1174 .
GeneIDi 3401472.
KEGGi rfe:RF_1174.
PATRICi 17893202. VBIRicFel64634_1414.

Phylogenomic databases

eggNOGi COG1159.
HOGENOMi HOG000245597.
KOi K03595.
OMAi HDNAQIV.
OrthoDBi EOG68DD1Q.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1208-MONOMER.

Family and domain databases

Gene3Di 3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00367. GTPase_Era.
InterProi IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view ]
Pfami PF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsi TIGR00436. era. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiERA_RICFE
AccessioniPrimary (citable) accession number: Q4UKB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi