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Q4UKB0 (ERA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase Era
Gene names
Name:era
Ordered Locus Names:RF_1174
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP-Rule MF_00367

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00367

Subcellular location

Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00367.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Era subfamily.

Contains 1 G (guanine nucleotide-binding) domain.

Contains 1 KH type-2 domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   Cellular componentCell inner membrane
Cell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Nucleotide-binding
RNA-binding
rRNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processribosomal small subunit biogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

SSU rRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293GTPase Era HAMAP-Rule MF_00367
PRO_0000277965

Regions

Domain18 – 123106G
Domain202 – 27978KH type-2
Nucleotide binding13 – 208GTP Potential
Nucleotide binding60 – 645GTP Potential
Nucleotide binding122 – 1254GTP Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UKB0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 82D1B619DA0DEE00

FASTA29333,694
        10         20         30         40         50         60 
MTKQKTISFC IIGRPNSGKS TLLNRIIGEK LSIVTPKVQT TRSIITGIIT LKDTQVILYD 

        70         80         90        100        110        120 
TPGIFEPKGT LEKAMVRCAW SSLHSADLVM LIIDSLKPFD DVMHDILDKL RSLNIVPIFL 

       130        140        150        160        170        180 
LNKIDIESKY LDDIKAFLTE NHPDSLLFPI SALSGKNIDG LLEYITGKAK ISPWLYAEDD 

       190        200        210        220        230        240 
ITDLPMRFIA AEITREQLFF NLQQELPYKL TVQTEKWEVL KDKSIKINQV IVVSRESYKT 

       250        260        270        280        290 
IILGKNGSKI KEIGAKSRMQ MERFFGFPVH LFLFVKVREL WENNQEFYQY MKI 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62025.1.
RefSeqYP_247190.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1174.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62025; AAY62025; RF_1174.
GeneID3401472.
KEGGrfe:RF_1174.
PATRIC17893202. VBIRicFel64634_1414.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1159.
HOGENOMHOG000245597.
KOK03595.
OMARCAWSSL.
OrthoDBEOG68DD1Q.
ProtClustDBPRK00089.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1208-MONOMER.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00367. GTPase_Era.
InterProIPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsTIGR00436. era. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS50823. KH_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERA_RICFE
AccessionPrimary (citable) accession number: Q4UKB0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names