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Q4UKB0

- ERA_RICFE

UniProt

Q4UKB0 - ERA_RICFE

Protein

GTPase Era

Gene

era

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208GTPUniRule annotation
    Nucleotide bindingi60 – 645GTPUniRule annotation
    Nucleotide bindingi122 – 1254GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-HAMAP
    3. small ribosomal subunit rRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ribosomal small subunit biogenesis Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1208-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase EraUniRule annotation
    Gene namesi
    Name:eraUniRule annotation
    Ordered Locus Names:RF_1174
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm. Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293GTPase EraPRO_0000277965Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_1174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 174170Era-type GAdd
    BLAST
    Domaini202 – 27978KH type-2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.UniRule annotation
    Contains 1 KH type-2 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1159.
    HOGENOMiHOG000245597.
    KOiK03595.
    OMAiHDNAQIV.
    OrthoDBiEOG68DD1Q.

    Family and domain databases

    Gene3Di3.30.300.20. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00367. GTPase_Era.
    InterProiIPR005662. GTP-bd_Era.
    IPR006073. GTP_binding_domain.
    IPR015946. KH_dom-like_a/b.
    IPR004044. KH_dom_type_2.
    IPR009019. KH_prok-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view]
    PfamiPF07650. KH_2. 1 hit.
    PF01926. MMR_HSR1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54814. SSF54814. 1 hit.
    TIGRFAMsiTIGR00436. era. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51713. G_ERA. 1 hit.
    PS50823. KH_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKQKTISFC IIGRPNSGKS TLLNRIIGEK LSIVTPKVQT TRSIITGIIT    50
    LKDTQVILYD TPGIFEPKGT LEKAMVRCAW SSLHSADLVM LIIDSLKPFD 100
    DVMHDILDKL RSLNIVPIFL LNKIDIESKY LDDIKAFLTE NHPDSLLFPI 150
    SALSGKNIDG LLEYITGKAK ISPWLYAEDD ITDLPMRFIA AEITREQLFF 200
    NLQQELPYKL TVQTEKWEVL KDKSIKINQV IVVSRESYKT IILGKNGSKI 250
    KEIGAKSRMQ MERFFGFPVH LFLFVKVREL WENNQEFYQY MKI 293
    Length:293
    Mass (Da):33,694
    Last modified:July 5, 2005 - v1
    Checksum:i82D1B619DA0DEE00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62025.1.
    RefSeqiWP_011271482.1. NC_007109.1.
    YP_247190.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62025; AAY62025; RF_1174.
    GeneIDi3401472.
    KEGGirfe:RF_1174.
    PATRICi17893202. VBIRicFel64634_1414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62025.1 .
    RefSeqi WP_011271482.1. NC_007109.1.
    YP_247190.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKB0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62025 ; AAY62025 ; RF_1174 .
    GeneIDi 3401472.
    KEGGi rfe:RF_1174.
    PATRICi 17893202. VBIRicFel64634_1414.

    Phylogenomic databases

    eggNOGi COG1159.
    HOGENOMi HOG000245597.
    KOi K03595.
    OMAi HDNAQIV.
    OrthoDBi EOG68DD1Q.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1208-MONOMER.

    Family and domain databases

    Gene3Di 3.30.300.20. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00367. GTPase_Era.
    InterProi IPR005662. GTP-bd_Era.
    IPR006073. GTP_binding_domain.
    IPR015946. KH_dom-like_a/b.
    IPR004044. KH_dom_type_2.
    IPR009019. KH_prok-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view ]
    Pfami PF07650. KH_2. 1 hit.
    PF01926. MMR_HSR1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54814. SSF54814. 1 hit.
    TIGRFAMsi TIGR00436. era. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51713. G_ERA. 1 hit.
    PS50823. KH_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiERA_RICFE
    AccessioniPrimary (citable) accession number: Q4UKB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3