ID   LEP_RICFE               Reviewed;         266 AA.
AC   Q4UKA7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Signal peptidase I;
DE            Short=SPase I;
DE            EC=3.4.21.89;
DE   AltName: Full=Leader peptidase I;
GN   Name=lepB; OrderedLocusNames=RF_1177;
OS   Rickettsia felis (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=42862;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II
CC       membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
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DR   EMBL; CP000053; AAY62028.1; -; Genomic_DNA.
DR   RefSeq; YP_247193.1; -.
DR   MEROPS; S26.001; -.
DR   GeneID; 3401475; -.
DR   GenomeReviews; CP000053_GR; RF_1177.
DR   KEGG; rfe:RF_1177; -.
DR   NMPDR; fig|315456.3.peg.1177; -.
DR   HOGENOM; Q4UKA7; -.
DR   OMA; Q4UKA7; KPWIESV.
DR   BioCyc; RFEL315456:RF_1177-MON; -.
DR   BRENDA; 3.4.21.89; 297363.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR   InterPro; IPR019759; Peptidase_S24_S26_cons-reg.
DR   InterPro; IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
DR   Gene3D; G3DSA:2.10.109.10; Pept_S24_S26_C; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00760; SPASE_I_2; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Hydrolase;
KW   Membrane; Transmembrane.
FT   CHAIN         1    266       Signal peptidase I.
FT                                /FTId=PRO_0000316275.
FT   TOPO_DOM      1     20       Cytoplasmic (Potential).
FT   TRANSMEM     21     41       Potential.
FT   TOPO_DOM     42    266       Periplasmic (Potential).
FT   ACT_SITE     45     45       By similarity.
FT   ACT_SITE    108    108       By similarity.
SQ   SEQUENCE   266 AA;  31119 MW;  D7CE673D20F67D45 CRC64;
     MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFT VPTGSMKATI LENDYIFSTK
     YSYGYSNYSL SFFDFIPLFK GRIFAREPER GDIVVFRPPN DMNVRYIKRL IGLPGDKIQL
     IDDVIYINDK KIERTEVGTY ISEEGIKYLK FKETLPNGRT YFSYKLAPIF GVIYNDRYGN
     TDVFYVPEGK YFFLGDNRDQ SNDSRVNLGF VPFENFIAKA QFIWLSTKIT WWDNDIGVIN
     LVLKLKPWIE SVRLNRIFRN LYSTDE
//