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Q4UKA7 (LEP_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal peptidase I

Short name=SPase I
EC=3.4.21.89
Alternative name(s):
Leader peptidase I
Gene names
Name:lepB
Ordered Locus Names:RF_1177
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Subcellular location

Cell inner membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the peptidase S26 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type peptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Signal peptidase I
PRO_0000316275

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121Helical; Potential
Topological domain42 – 266225Periplasmic Potential

Sites

Active site451 By similarity
Active site1081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UKA7 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: D7CE673D20F67D45

FASTA26631,119
        10         20         30         40         50         60 
MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFT VPTGSMKATI LENDYIFSTK 

        70         80         90        100        110        120 
YSYGYSNYSL SFFDFIPLFK GRIFAREPER GDIVVFRPPN DMNVRYIKRL IGLPGDKIQL 

       130        140        150        160        170        180 
IDDVIYINDK KIERTEVGTY ISEEGIKYLK FKETLPNGRT YFSYKLAPIF GVIYNDRYGN 

       190        200        210        220        230        240 
TDVFYVPEGK YFFLGDNRDQ SNDSRVNLGF VPFENFIAKA QFIWLSTKIT WWDNDIGVIN 

       250        260 
LVLKLKPWIE SVRLNRIFRN LYSTDE 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62028.1.
RefSeqYP_247193.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62028; AAY62028; RF_1177.
GeneID3401475.
KEGGrfe:RF_1177.
PATRIC17893208. VBIRicFel64634_1417.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0681.
HOGENOMHOG000003673.
KOK03100.
OMALYFWTWR.
OrthoDBEOG6KDKTM.
ProtClustDBCLSK870751.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1211-MONOMER.

Family and domain databases

Gene3D2.10.109.10. 2 hits.
InterProIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERPTHR12383. PTHR12383. 1 hit.
PfamPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00727. LEADERPTASE.
SUPFAMSSF51306. SSF51306. 1 hit.
TIGRFAMsTIGR02227. sigpep_I_bact. 1 hit.
PROSITEPS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEP_RICFE
AccessionPrimary (citable) accession number: Q4UKA7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

Peptidase families

Classification of peptidase families and list of entries