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Q4UKA7

- LEP_RICFE

UniProt

Q4UKA7 - LEP_RICFE

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Protein
Signal peptidase I
Gene
lepB, RF_1177
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity
Active sitei108 – 1081 By similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1211-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:RF_1177
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei21 – 4121Helical; Reviewed prediction
Add
BLAST
Topological domaini42 – 266225Periplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Signal peptidase I
PRO_0000316275Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1177.

Structurei

3D structure databases

ProteinModelPortaliQ4UKA7.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0681.
HOGENOMiHOG000003673.
KOiK03100.
OMAiLYFWTWR.
OrthoDBiEOG6KDKTM.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UKA7-1 [UniParc]FASTAAdd to Basket

« Hide

MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFT VPTGSMKATI    50
LENDYIFSTK YSYGYSNYSL SFFDFIPLFK GRIFAREPER GDIVVFRPPN 100
DMNVRYIKRL IGLPGDKIQL IDDVIYINDK KIERTEVGTY ISEEGIKYLK 150
FKETLPNGRT YFSYKLAPIF GVIYNDRYGN TDVFYVPEGK YFFLGDNRDQ 200
SNDSRVNLGF VPFENFIAKA QFIWLSTKIT WWDNDIGVIN LVLKLKPWIE 250
SVRLNRIFRN LYSTDE 266
Length:266
Mass (Da):31,119
Last modified:July 5, 2005 - v1
Checksum:iD7CE673D20F67D45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62028.1.
RefSeqiWP_011271485.1. NC_007109.1.
YP_247193.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62028; AAY62028; RF_1177.
GeneIDi3401475.
KEGGirfe:RF_1177.
PATRICi17893208. VBIRicFel64634_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62028.1 .
RefSeqi WP_011271485.1. NC_007109.1.
YP_247193.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UKA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62028 ; AAY62028 ; RF_1177 .
GeneIDi 3401475.
KEGGi rfe:RF_1177.
PATRICi 17893208. VBIRicFel64634_1417.

Phylogenomic databases

eggNOGi COG0681.
HOGENOMi HOG000003673.
KOi K03100.
OMAi LYFWTWR.
OrthoDBi EOG6KDKTM.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1211-MONOMER.

Family and domain databases

Gene3Di 2.10.109.10. 2 hits.
InterProi IPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view ]
PANTHERi PTHR12383. PTHR12383. 1 hit.
Pfami PF00717. Peptidase_S24. 1 hit.
[Graphical view ]
PRINTSi PR00727. LEADERPTASE.
SUPFAMi SSF51306. SSF51306. 1 hit.
TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
PROSITEi PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiLEP_RICFE
AccessioniPrimary (citable) accession number: Q4UKA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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