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Q4UKA7

- LEP_RICFE

UniProt

Q4UKA7 - LEP_RICFE

Protein

Signal peptidase I

Gene

lepB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451By similarity
    Active sitei108 – 1081By similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1211-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase I (EC:3.4.21.89)
    Short name:
    SPase I
    Alternative name(s):
    Leader peptidase I
    Gene namesi
    Name:lepB
    Ordered Locus Names:RF_1177
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Signal peptidase IPRO_0000316275Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini42 – 266225PeriplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    HOGENOMiHOG000003673.
    KOiK03100.
    OMAiLYFWTWR.
    OrthoDBiEOG6KDKTM.

    Family and domain databases

    Gene3Di2.10.109.10. 2 hits.
    InterProiIPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view]
    PANTHERiPTHR12383. PTHR12383. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00727. LEADERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
    PROSITEiPS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKA7-1 [UniParc]FASTAAdd to Basket

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    MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFT VPTGSMKATI    50
    LENDYIFSTK YSYGYSNYSL SFFDFIPLFK GRIFAREPER GDIVVFRPPN 100
    DMNVRYIKRL IGLPGDKIQL IDDVIYINDK KIERTEVGTY ISEEGIKYLK 150
    FKETLPNGRT YFSYKLAPIF GVIYNDRYGN TDVFYVPEGK YFFLGDNRDQ 200
    SNDSRVNLGF VPFENFIAKA QFIWLSTKIT WWDNDIGVIN LVLKLKPWIE 250
    SVRLNRIFRN LYSTDE 266
    Length:266
    Mass (Da):31,119
    Last modified:July 5, 2005 - v1
    Checksum:iD7CE673D20F67D45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62028.1.
    RefSeqiWP_011271485.1. NC_007109.1.
    YP_247193.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62028; AAY62028; RF_1177.
    GeneIDi3401475.
    KEGGirfe:RF_1177.
    PATRICi17893208. VBIRicFel64634_1417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62028.1 .
    RefSeqi WP_011271485.1. NC_007109.1.
    YP_247193.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62028 ; AAY62028 ; RF_1177 .
    GeneIDi 3401475.
    KEGGi rfe:RF_1177.
    PATRICi 17893208. VBIRicFel64634_1417.

    Phylogenomic databases

    eggNOGi COG0681.
    HOGENOMi HOG000003673.
    KOi K03100.
    OMAi LYFWTWR.
    OrthoDBi EOG6KDKTM.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1211-MONOMER.

    Family and domain databases

    Gene3Di 2.10.109.10. 2 hits.
    InterProi IPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view ]
    PANTHERi PTHR12383. PTHR12383. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00727. LEADERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
    PROSITEi PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiLEP_RICFE
    AccessioniPrimary (citable) accession number: Q4UKA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3