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Q4UKA6 (NUOF_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit F

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit F
NDH-1 subunit F
Gene names
Name:nuoF
Ordered Locus Names:RF_1178
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422NADH-quinone oxidoreductase subunit F
PRO_0000274788

Regions

Nucleotide binding54 – 6310NAD By similarity
Nucleotide binding166 – 21348FMN By similarity

Sites

Metal binding3441Iron-sulfur (4Fe-4S) Potential
Metal binding3471Iron-sulfur (4Fe-4S) Potential
Metal binding3501Iron-sulfur (4Fe-4S) Potential
Metal binding3901Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UKA6 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 7DDC06F6B836DC5E

FASTA42246,224
        10         20         30         40         50         60 
MLKEEDKIFT NLHGQQSHDL KSSKKRGDWD NTKALLDKGR EFIIEEVKKS GLRGRGGAGF 

        70         80         90        100        110        120 
STGMKWSFMP KNSAKPCYLV VNADESEPGT CKDRDILRFE PHKLIEGCLL ASFAIGANDC 

       130        140        150        160        170        180 
YIYIRGEFYN EASNIQRALD EAYKDGLIGK NACGSGFDCN IYLHRGAGAY ICGEETALLE 

       190        200        210        220        230        240 
SLEGKKGMPR LKPPFPAGFG LYGCPTTINN VESIAVVPTI LRRGASWFAS IGKPNNTGTK 

       250        260        270        280        290        300 
IFCISGHVNK PCNVEEAMGI SLKELIEKYA GGVRGGWDNL KAIIPGGSSV PLLPKSLCEV 

       310        320        330        340        350        360 
DMDFDSLRTA GSGLGTGGII VMDKSTDIIY AIARLSKFYM HESCGQCTPC REGTGWMWRV 

       370        380        390        400        410        420 
MMRLVKGNAQ KSEIDELLNV TKEIEGHTIC ALGDAAAWPI QGLIRHFRSE IEERIKGWSS 


AI 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62029.1.
RefSeqYP_247194.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UKA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62029; AAY62029; RF_1178.
GeneID3401476.
KEGGrfe:RF_1178.
PATRIC17893210. VBIRicFel64634_1418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1894.
HOGENOMHOG000251534.
KOK00335.
OMAANVAFIY.
OrthoDBEOG6W9XGK.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1212-MONOMER.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. nuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOF_RICFE
AccessionPrimary (citable) accession number: Q4UKA6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names