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Q4UKA6

- NUOF_RICFE

UniProt

Q4UKA6 - NUOF_RICFE

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Protein
NADH-quinone oxidoreductase subunit F
Gene
nuoF, RF_1178
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activityi

NADH + quinone = NAD+ + quinol.

Cofactori

Binds 1 FMN Reviewed prediction.
Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi344 – 3441Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi347 – 3471Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi350 – 3501Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi390 – 3901Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 6310NAD By similarity
Nucleotide bindingi166 – 21348FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. FMN binding Source: InterPro
  3. NAD binding Source: InterPro
  4. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. quinone binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1212-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit F (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit F
    NDH-1 subunit F
    Gene namesi
    Name:nuoF
    Ordered Locus Names:RF_1178
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422NADH-quinone oxidoreductase subunit F
    PRO_0000274788Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UKA6.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1894.
    HOGENOMiHOG000251534.
    KOiK00335.
    OMAiANVAFIY.
    OrthoDBiEOG6W9XGK.

    Family and domain databases

    InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view]
    PfamiPF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view]
    SMARTiSM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
    PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UKA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKEEDKIFT NLHGQQSHDL KSSKKRGDWD NTKALLDKGR EFIIEEVKKS    50
    GLRGRGGAGF STGMKWSFMP KNSAKPCYLV VNADESEPGT CKDRDILRFE 100
    PHKLIEGCLL ASFAIGANDC YIYIRGEFYN EASNIQRALD EAYKDGLIGK 150
    NACGSGFDCN IYLHRGAGAY ICGEETALLE SLEGKKGMPR LKPPFPAGFG 200
    LYGCPTTINN VESIAVVPTI LRRGASWFAS IGKPNNTGTK IFCISGHVNK 250
    PCNVEEAMGI SLKELIEKYA GGVRGGWDNL KAIIPGGSSV PLLPKSLCEV 300
    DMDFDSLRTA GSGLGTGGII VMDKSTDIIY AIARLSKFYM HESCGQCTPC 350
    REGTGWMWRV MMRLVKGNAQ KSEIDELLNV TKEIEGHTIC ALGDAAAWPI 400
    QGLIRHFRSE IEERIKGWSS AI 422
    Length:422
    Mass (Da):46,224
    Last modified:July 5, 2005 - v1
    Checksum:i7DDC06F6B836DC5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62029.1.
    RefSeqiYP_247194.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62029; AAY62029; RF_1178.
    GeneIDi3401476.
    KEGGirfe:RF_1178.
    PATRICi17893210. VBIRicFel64634_1418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62029.1 .
    RefSeqi YP_247194.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UKA6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62029 ; AAY62029 ; RF_1178 .
    GeneIDi 3401476.
    KEGGi rfe:RF_1178.
    PATRICi 17893210. VBIRicFel64634_1418.

    Phylogenomic databases

    eggNOGi COG1894.
    HOGENOMi HOG000251534.
    KOi K00335.
    OMAi ANVAFIY.
    OrthoDBi EOG6W9XGK.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1212-MONOMER.

    Family and domain databases

    InterProi IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view ]
    Pfami PF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view ]
    SMARTi SM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01959. nuoF_fam. 1 hit.
    PROSITEi PS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiNUOF_RICFE
    AccessioniPrimary (citable) accession number: Q4UKA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2005
    Last modified: May 14, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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