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Protein

Hemolysin C

Gene

tlyC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
Ordered Locus Names:RF_1185
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190311 – 299Hemolysin CAdd BLAST299

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1185

Structurei

3D structure databases

ProteinModelPortaliQ4UK99
SMRiQ4UK99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 142CBS 1PROSITE-ProRule annotationAdd BLAST63
Domaini145 – 202CBS 2PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the UPF0053 family. Hemolysin C subfamily.Curated

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4107RCQ Bacteria
COG1253 LUCA
HOGENOMiHOG000062294
OMAiERRHMAL
OrthoDBiPOG091H025R

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR036318 FAD-bd_2-like_sf
IPR005170 Transptr-assoc_dom
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF03471 CorC_HlyC, 1 hit
SMARTiView protein in SMART
SM01091 CorC_HlyC, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

Q4UK99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL
60 70 80 90 100
KINSQKMTLD ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE
110 120 130 140 150
SIKLEVPHTR TLIYDGTLDN VVGFIHIKDL FKALATKQNG RLKKLIRKHI
160 170 180 190 200
IAAPSMKLLD LLAKMRRERT HIAIVVDEYG GTDGLVTIED LIEEIVGRID
210 220 230 240 250
DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLK NDDDEFDTIG
260 270 280 290
GLVLTRVGSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNSK
Length:299
Mass (Da):33,883
Last modified:July 5, 2005 - v1
Checksum:i1062D73CDC0A902D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY62036.1
RefSeqiWP_011271490.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185
KEGGirfe:RF_1185

Similar proteinsi

Entry informationi

Entry nameiHLYC_RICFE
AccessioniPrimary (citable) accession number: Q4UK99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health