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Protein

Hemolysin C

Gene

tlyC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Virulence

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
Ordered Locus Names:RF_1185
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Hemolysin CPRO_0000319031Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1185.

Structurei

3D structure databases

ProteinModelPortaliQ4UK99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14263CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini145 – 20258CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family. Hemolysin C subfamily.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG1253.
HOGENOMiHOG000062294.
OMAiNRGETQD.
OrthoDBiEOG60W7V4.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UK99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL
60 70 80 90 100
KINSQKMTLD ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE
110 120 130 140 150
SIKLEVPHTR TLIYDGTLDN VVGFIHIKDL FKALATKQNG RLKKLIRKHI
160 170 180 190 200
IAAPSMKLLD LLAKMRRERT HIAIVVDEYG GTDGLVTIED LIEEIVGRID
210 220 230 240 250
DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLK NDDDEFDTIG
260 270 280 290
GLVLTRVGSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNSK
Length:299
Mass (Da):33,883
Last modified:July 5, 2005 - v1
Checksum:i1062D73CDC0A902D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1.
RefSeqiYP_247201.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
KEGGirfe:RF_1185.
PATRICi17893224. VBIRicFel64634_1425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1.
RefSeqiYP_247201.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UK99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
KEGGirfe:RF_1185.
PATRICi17893224. VBIRicFel64634_1425.

Phylogenomic databases

eggNOGiCOG1253.
HOGENOMiHOG000062294.
OMAiNRGETQD.
OrthoDBiEOG60W7V4.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1219-MONOMER.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], HEMOLYTIC ACTIVITY.
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiHLYC_RICFE
AccessioniPrimary (citable) accession number: Q4UK99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.