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Q4UK99

- HLYC_RICFE

UniProt

Q4UK99 - HLYC_RICFE

Protein

Hemolysin C

Gene

tlyC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

    GO - Biological processi

    1. hemolysis in other organism Source: UniProtKB-KW
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Toxin

    Keywords - Biological processi

    Cytolysis, Hemolysis, Virulence

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1219-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemolysin C
    Gene namesi
    Name:tlyC
    Ordered Locus Names:RF_1185
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Hemolysin CPRO_0000319031Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UK99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 14263CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini145 – 20258CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0053 family. Hemolysin C subfamily.Curated
    Contains 2 CBS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    eggNOGiCOG1253.
    HOGENOMiHOG000062294.
    OMAiRSNRNHI.
    OrthoDBiEOG60W7V4.

    Family and domain databases

    Gene3Di3.30.465.10. 1 hit.
    InterProiIPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view]
    PfamiPF00571. CBS. 1 hit.
    PF03471. CorC_HlyC. 1 hit.
    [Graphical view]
    SMARTiSM00116. CBS. 2 hits.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UK99-1 [UniParc]FASTAAdd to Basket

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    MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL    50
    KINSQKMTLD ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE 100
    SIKLEVPHTR TLIYDGTLDN VVGFIHIKDL FKALATKQNG RLKKLIRKHI 150
    IAAPSMKLLD LLAKMRRERT HIAIVVDEYG GTDGLVTIED LIEEIVGRID 200
    DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLK NDDDEFDTIG 250
    GLVLTRVGSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNSK 299
    Length:299
    Mass (Da):33,883
    Last modified:July 5, 2005 - v1
    Checksum:i1062D73CDC0A902D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62036.1.
    RefSeqiWP_011271490.1. NC_007109.1.
    YP_247201.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
    GeneIDi3401483.
    KEGGirfe:RF_1185.
    PATRICi17893224. VBIRicFel64634_1425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62036.1 .
    RefSeqi WP_011271490.1. NC_007109.1.
    YP_247201.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UK99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62036 ; AAY62036 ; RF_1185 .
    GeneIDi 3401483.
    KEGGi rfe:RF_1185.
    PATRICi 17893224. VBIRicFel64634_1425.

    Phylogenomic databases

    eggNOGi COG1253.
    HOGENOMi HOG000062294.
    OMAi RSNRNHI.
    OrthoDBi EOG60W7V4.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1219-MONOMER.

    Family and domain databases

    Gene3Di 3.30.465.10. 1 hit.
    InterProi IPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view ]
    Pfami PF00571. CBS. 1 hit.
    PF03471. CorC_HlyC. 1 hit.
    [Graphical view ]
    SMARTi SM00116. CBS. 2 hits.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], HEMOLYTIC ACTIVITY.
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiHLYC_RICFE
    AccessioniPrimary (citable) accession number: Q4UK99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3