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Q4UK99

- HLYC_RICFE

UniProt

Q4UK99 - HLYC_RICFE

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Protein

Hemolysin C

Gene

tlyC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Virulence

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
Ordered Locus Names:RF_1185
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Hemolysin CPRO_0000319031Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1185.

Structurei

3D structure databases

ProteinModelPortaliQ4UK99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14263CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini145 – 20258CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family. Hemolysin C subfamily.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG1253.
HOGENOMiHOG000062294.
OMAiRSNRNHI.
OrthoDBiEOG60W7V4.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UK99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL
60 70 80 90 100
KINSQKMTLD ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE
110 120 130 140 150
SIKLEVPHTR TLIYDGTLDN VVGFIHIKDL FKALATKQNG RLKKLIRKHI
160 170 180 190 200
IAAPSMKLLD LLAKMRRERT HIAIVVDEYG GTDGLVTIED LIEEIVGRID
210 220 230 240 250
DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLK NDDDEFDTIG
260 270 280 290
GLVLTRVGSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNSK
Length:299
Mass (Da):33,883
Last modified:July 5, 2005 - v1
Checksum:i1062D73CDC0A902D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1.
RefSeqiWP_011271490.1. NC_007109.1.
YP_247201.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
GeneIDi3401483.
KEGGirfe:RF_1185.
PATRICi17893224. VBIRicFel64634_1425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1 .
RefSeqi WP_011271490.1. NC_007109.1.
YP_247201.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UK99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62036 ; AAY62036 ; RF_1185 .
GeneIDi 3401483.
KEGGi rfe:RF_1185.
PATRICi 17893224. VBIRicFel64634_1425.

Phylogenomic databases

eggNOGi COG1253.
HOGENOMi HOG000062294.
OMAi RSNRNHI.
OrthoDBi EOG60W7V4.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1219-MONOMER.

Family and domain databases

Gene3Di 3.30.465.10. 1 hit.
InterProi IPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view ]
Pfami PF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view ]
SMARTi SM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], HEMOLYTIC ACTIVITY.
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiHLYC_RICFE
AccessioniPrimary (citable) accession number: Q4UK99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3