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Protein

Hemolysin C

Gene

tlyC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
Ordered Locus Names:RF_1185
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190311 – 299Hemolysin CAdd BLAST299

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1185.

Structurei

3D structure databases

ProteinModelPortaliQ4UK99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 142CBS 1PROSITE-ProRule annotationAdd BLAST63
Domaini145 – 202CBS 2PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the UPF0053 family. Hemolysin C subfamily.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4107RCQ. Bacteria.
COG1253. LUCA.
HOGENOMiHOG000062294.
OMAiFDETEDN.
OrthoDBiPOG091H025R.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UK99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL
60 70 80 90 100
KINSQKMTLD ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE
110 120 130 140 150
SIKLEVPHTR TLIYDGTLDN VVGFIHIKDL FKALATKQNG RLKKLIRKHI
160 170 180 190 200
IAAPSMKLLD LLAKMRRERT HIAIVVDEYG GTDGLVTIED LIEEIVGRID
210 220 230 240 250
DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLK NDDDEFDTIG
260 270 280 290
GLVLTRVGSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNSK
Length:299
Mass (Da):33,883
Last modified:July 5, 2005 - v1
Checksum:i1062D73CDC0A902D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1.
RefSeqiWP_011271490.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
KEGGirfe:RF_1185.
PATRICi17893224. VBIRicFel64634_1425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62036.1.
RefSeqiWP_011271490.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UK99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY62036; AAY62036; RF_1185.
KEGGirfe:RF_1185.
PATRICi17893224. VBIRicFel64634_1425.

Phylogenomic databases

eggNOGiENOG4107RCQ. Bacteria.
COG1253. LUCA.
HOGENOMiHOG000062294.
OMAiFDETEDN.
OrthoDBiPOG091H025R.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHLYC_RICFE
AccessioniPrimary (citable) accession number: Q4UK99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.