Q4UK94 (GLRX2_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable monothiol glutaredoxin-2

Gene names

Name:	grxC2
Synonyms:	grlA
Ordered Locus Names:	RF_1190

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Probable monothiol glutaredoxin-2		PRO_0000288732
Regions
	Domain	7 – 104	98	Glutaredoxin
	Region	86 – 87	2	Glutathione binding By similarity
Sites
	Metal binding	32	1	Iron-sulfur (2Fe-2S); shared with dimeric partner By similarity
	Binding site	24	1	Glutathione By similarity
	Binding site	61	1	Glutathione By similarity
	Binding site	73	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UK94 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 9BE58663ECB9AFE4	FASTA	104	11,918
	10 20 30 40 50 60 MTENKNFEFI ENEIKNNKVV LFMKGTKEAT MCGFSAKVVA ILNKLGVEFR DINVFVNPEF 70 80 90 100 REDLKKFSDW PTFPQLYIKG ELVGGCDIAT ELYNNGELEK MLKG

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY62041.1.
RefSeq	YP_247206.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 1WIK based on UniProtKB Q9CQM9.
ProteinModelPortal	Q4UK94.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3401488.
GenomeReviews	Gene locus RF_1190 in contig CP000053_GR.
KEGG	rfe:RF_1190.
NMPDR	fig|315456.3.peg.1190.
PATRIC	17893238. VBIRicFel64634_1432.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG728471.
OMA	NGELEKM.
ProtClustDB	CLSK937612.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_1190-MONOMER.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR014434. Monothiol_GRX. IPR004480. Monothiol_GRX-rel. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K07390.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF005894. Monothiol_GRX. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00365. TIGR00365. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX2_RICFE

Accession

Primary (citable) accession number: Q4UK94

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program