Reviewed, UniProtKB/Swiss-Prot Q4UK84 (AK_RICFE)

Names and originHide

Protein names

Recommended name:
Aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	RF_1200

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributesHide

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

OntologiesHide

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Aspartokinase		PRO_0000288720

SequencesHide

	Sequence		Length	Mass (Da)
	Q4UK84-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 5492DB95BBA62FA0	FASTA	401	44,340
	10 20 30 40 50 60 MALIIQKFGG TSVANIDRIK KIAPIIKAEI AKNNQVIVVV SAMAGVTNQL VTLCNEVSSL 70 80 90 100 110 120 NNISQFAEYD VALSSGEIVT ASLLALALQE EDIKAQSFLA WQLPILTDNN HSKALVESIT 130 140 150 160 170 180 TDLLEKYLQL NTVPIIAGFQ GTNKSNRLTT LGRGGSDTTA ALIAAAMKAK RCDIYTDVEG 190 200 210 220 230 240 IFTADPRIIP NAKKIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFSPNTE 250 260 270 280 290 300 GTLITSKDKN MENGIINSIT SNKNLLKISV KSISLSFLQV ANMITQNNNH IEFMQEIKNN 310 320 330 340 350 360 EEYSFITNLT DENNLQALLT NLKNDKQIQD FTFDAEIATI SLIGYGIKND CKVLEMILSK 370 380 390 400 LTKDNINVNM IQLSEVKITL LINDQDAEKT IFNLYNLFKI S

ReferencesHide

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY62051.1.
RefSeq	YP_247216.1.
3D structure databases
HSSP	HSSP built from PDB template 2BNF based on UniProtKB P0A7E9.
ModBase	Search...
Genome annotation databases
GeneID	3401498.
GenomeReviews	Gene locus RF_1200 in contig CP000053_GR.
KEGG	rfe:RF_1200.
NMPDR	fig|315456.3.peg.1200.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG724395.
OMA	NKSNRLT.
ProtClustDB	PRK06635.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_1200-MONOMER.
BRENDA	2.7.2.4. 297363.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

AK_RICFE

Accession

Primary (citable) accession number: Q4UK84

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2005
Last modified:	July 13, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)