Q4UK62 (FABG_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100

Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase

Gene names

Name:	fabG
Ordered Locus Names:	RF_1222

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid elongation Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Inferred from sequence or structural similarity. Source: UniProtKB NAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-oxoacyl-[acyl-carrier-protein] reductase FabG		PRO_0000286633
Regions
	Nucleotide binding	13 – 16	4	NADP By similarity
	Nucleotide binding	57 – 58	2	NADP By similarity
	Nucleotide binding	148 – 152	5	NADP By similarity
Sites
	Active site	148	1	Proton acceptor By similarity
	Binding site	38	1	NADP By similarity
	Binding site	83	1	NADP; via carbonyl oxygen By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	181	1	NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UK62 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 396CFC31A4EF6814	FASTA	241	25,749
	10 20 30 40 50 60 MIDLTGKTSL ITGASGGIGG AIARLLHKLG SHVIISGSNE EKLKSLGNVL KDNYTIEICN 70 80 90 100 110 120 LANKEECSNL ISKAPKLDIL VCNAGITSDT LAIRMKDEDF DKVIDINLKA NFILNREAIK 130 140 150 160 170 180 KMMQNRYGRI INISSIVGIS GNPGQANYCA SKAGLIGMTK SLSYEVATRG ITVNAVAPGF 190 200 210 220 230 240 IKSDMTDKLN EKQREAIVQK IPLGTYGMPE DVANAVAFLA SDQASYITGQ TIHVNGGMLM V

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY62073.1.
RefSeq	YP_247238.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 2FWM based on UniProtKB P15047.
ProteinModelPortal	Q4UK62.
SMR	Q4UK62. Positions 7-239.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1222.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY62073; AAY62073; RF_1222.
GeneID	3401332.
KEGG	rfe:RF_1222.
PATRIC	17893314. VBIRicFel64634_1470.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1028.
KO	K00059.
OMA	VEAHQGP.
ProtClustDB	PRK05653.
Enzyme and pathway databases
UniPathway	UPA00094.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_RICFE

Accession

Primary (citable) accession number: Q4UK62

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program