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Q4UK62 (FABG_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:RF_1222
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000286633

Regions

Nucleotide binding13 – 164NADP By similarity
Nucleotide binding57 – 582NADP By similarity
Nucleotide binding148 – 1525NADP By similarity

Sites

Active site1481Proton acceptor By similarity
Binding site381NADP By similarity
Binding site831NADP; via carbonyl oxygen By similarity
Binding site1351Substrate By similarity
Binding site1811NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UK62 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 396CFC31A4EF6814

FASTA24125,749
        10         20         30         40         50         60 
MIDLTGKTSL ITGASGGIGG AIARLLHKLG SHVIISGSNE EKLKSLGNVL KDNYTIEICN 

        70         80         90        100        110        120 
LANKEECSNL ISKAPKLDIL VCNAGITSDT LAIRMKDEDF DKVIDINLKA NFILNREAIK 

       130        140        150        160        170        180 
KMMQNRYGRI INISSIVGIS GNPGQANYCA SKAGLIGMTK SLSYEVATRG ITVNAVAPGF 

       190        200        210        220        230        240 
IKSDMTDKLN EKQREAIVQK IPLGTYGMPE DVANAVAFLA SDQASYITGQ TIHVNGGMLM 


V 

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62073.1.
RefSeqYP_247238.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UK62.
SMRQ4UK62. Positions 7-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62073; AAY62073; RF_1222.
GeneID3401332.
KEGGrfe:RF_1222.
PATRIC17893314. VBIRicFel64634_1470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMATGQELHV.
OrthoDBEOG6N3CR8.
ProtClustDBPRK05653.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1256-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_RICFE
AccessionPrimary (citable) accession number: Q4UK62
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: November 13, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways