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Q4UK49

- FABH_RICFE

UniProt

Q4UK49 - FABH_RICFE

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 3
Gene
fabH, RF_1235
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121 By similarity
Active sitei244 – 2441 By similarity
Active sitei274 – 2741 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1270-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC:2.3.1.180)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name:
KAS III
Gene namesi
Name:fabH
Ordered Locus Names:RF_1235
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3173173-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation
PRO_0000272376Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1235.

Structurei

3D structure databases

ProteinModelPortaliQ4UK49.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni245 – 2495ACP-binding By similarity

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.

Phylogenomic databases

eggNOGiCOG0332.
HOGENOMiHOG000246674.
KOiK00648.
OMAiIRIMEAA.
OrthoDBiEOG6J74XN.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UK49-1 [UniParc]FASTAAdd to Basket

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MTCKIIGSGG YLPSKIVSND ELAKFVDTND EWIRTRTGIT QRHIAGDTEY    50
TSHLALKSAE KAIADARVSV NDIDLIITCT TTPDNSFPSV ASKLQGYLGL 100
TNIPSFDLQA VCAGFVYGLQ VANSLIASGK YKTVLLIGAE KMTSLLDWSD 150
RSTCVLFGDG AGSVILQRSS DDSGLIDSNI FSSGADYEIL YTNGGVSMNG 200
ISGKIVMQGQ KLFRHAIEKM QQSIEDLLHA NQFSVSDIDY FIPHQANIRI 250
INKLAELLNI EEHKVVKTVE KHANCSAASI PLALSTLKAS GKIKKGDILL 300
FSAIGAGLTW GSALIRW 317
Length:317
Mass (Da):34,206
Last modified:July 5, 2005 - v1
Checksum:i741B91B0F957621C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62086.1.
RefSeqiYP_247251.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62086; AAY62086; RF_1235.
GeneIDi3401346.
KEGGirfe:RF_1235.
PATRICi17893346. VBIRicFel64634_1485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62086.1 .
RefSeqi YP_247251.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UK49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62086 ; AAY62086 ; RF_1235 .
GeneIDi 3401346.
KEGGi rfe:RF_1235.
PATRICi 17893346. VBIRicFel64634_1485.

Phylogenomic databases

eggNOGi COG0332.
HOGENOMi HOG000246674.
KOi K00648.
OMAi IRIMEAA.
OrthoDBi EOG6J74XN.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RFEL315456:GKEK-1270-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
HAMAPi MF_01815. FabH.
InterProi IPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 1 hit.
TIGRFAMsi TIGR00747. fabH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiFABH_RICFE
AccessioniPrimary (citable) accession number: Q4UK49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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