Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4UK46 (FTSY_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal recognition particle receptor FtsY

Short name=SRP receptor
Gene names
Name:ftsY
Ordered Locus Names:RF_1238
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components By similarity. HAMAP-Rule MF_00920

Subunit structure

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm By similarity HAMAP-Rule MF_00920.

Sequence similarities

Belongs to the GTP-binding SRP family. FtsY subfamily.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Nucleotide-binding
   Molecular functionReceptor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSRP-dependent cotranslational protein targeting to membrane

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

intrinsic component of plasma membrane

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Signal recognition particle receptor FtsY HAMAP-Rule MF_00920
PRO_0000286496

Regions

Nucleotide binding108 – 1158GTP By similarity
Nucleotide binding190 – 1945GTP By similarity
Nucleotide binding254 – 2574GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UK46 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: B36C66A22809CFE2

FASTA30333,298
        10         20         30         40         50         60 
MISIFSKLKQ SLSKTSNKIS KGIDKIFYKK KLDTETLEEL EELLIASDMS VSVVTNIIEE 

        70         80         90        100        110        120 
FKKVKFDKEI DSDTVKEALA ELIEQQLSKS EIPFTLNENK LNVILVCGVN GAGKTTTIGK 

       130        140        150        160        170        180 
LAAMYGMQGK KVAVAACDTF RAAAVNQLST WVDRANALLI TGEESADPAS VAYRAMEESI 

       190        200        210        220        230        240 
KQNIDILFID TAGRLHNKKN LMDELSKIVK VIKKLDENAP THSVLVIDAI TGQNTYNQVE 

       250        260        270        280        290        300 
HFNDATNLTG LIVTKLDGSA KAGVLVGVVQ KFNLPVYFIG IGEKIEDLKI FNRHDFAKSL 


VGL 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62089.1.
RefSeqYP_247254.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UK46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1238.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62089; AAY62089; RF_1238.
GeneID3401349.
KEGGrfe:RF_1238.
PATRIC17893354. VBIRicFel64634_1489.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0552.
HOGENOMHOG000036278.
KOK03110.
OMAIVISIKH.
OrthoDBEOG62K1ZH.
ProtClustDBPRK10416.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1273-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00920. FtsY.
InterProIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00064. ftsY. 1 hit.
PROSITEPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSY_RICFE
AccessionPrimary (citable) accession number: Q4UK46
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names