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Q4UK40

- DPO3A_RICFE

UniProt

Q4UK40 - DPO3A_RICFE

Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. DNA binding Source: InterPro
    3. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1279-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit alpha (EC:2.7.7.7)
    Gene namesi
    Name:dnaE
    Ordered Locus Names:RF_1244
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12071207DNA polymerase III subunit alphaPRO_0000280957Add
    BLAST

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_1244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UK40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0587.
    HOGENOMiHOG000021784.
    KOiK02337.
    OMAiFCMDGRD.
    OrthoDBiEOG6CZQGR.

    Family and domain databases

    InterProiIPR011708. DNA_pol3_alpha.
    IPR029460. DNAPol_HHH.
    IPR004013. PHP_C.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view]
    PfamiPF07733. DNA_pol3_alpha. 1 hit.
    PF14579. HHH_6. 1 hit.
    PF02811. PHP. 1 hit.
    [Graphical view]
    SMARTiSM00481. POLIIIAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.
    TIGRFAMsiTIGR00594. polc. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UK40-1 [UniParc]FASTAAdd to Basket

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    MRPEFIHLRT QSSYSFLESA LTIEKVVELA SSNKMPAICL ADKGNLFGSL     50
    EFALYAVKKG LQPIHGVILN IKYDIDIFAQ ILLIAKDETG YKNLLKLSSL 100
    TFTKNDRKLC DHIDFEDLIE YQEGLIALCC YTDGIVGKCL LARSEEQAML 150
    FARKLQDILG DRFYFEIMRH DLPEEQFIED SYIRIAAELA IPLVATNKVL 200
    FSEKTMHDAH DVLLCISAGV TKEYPDRKTV SENCYFRSPH EMIELFSDLP 250
    SAIQNTVNLR ERCYFAAHAN PPMLPNFATK DISETDLIRK DAKEGLLARL 300
    ATKFKSENIP LQNQEELKTE YFARLNYELD IICNMNFAGY FLIVSDFIKW 350
    SKKEGILVGP GRGSGAGSVV AWSLLITDLD PIKFGLLFER FLNPERISMP 400
    DFDIDFCQER REEVINYVRS KYGNNRVGQI ITFGKMQAKA VIKDVARVLS 450
    LPYKFADYLT ELVPFSAVNP VSLEQAMREV PELANAAKGN GLYNLEGEAE 500
    LIKLVLDTSL ILEGLHRHSS THAAGIVIAG TDLVDIVPVY KDANSDMLVV 550
    GYSMKYSEIA GLIKFDFLGL QTLTVITDCK KLLKEQGIEV DFNNMTFDDN 600
    KTYQMLCKGK GVGVFQFESI GMKDALRRLK PDSIHDLIAL GALYRPGPME 650
    NIPTYIACKH KLQQPDYLHE LLKPILEETY GVVIYQEQVQ RIAQILAGYT 700
    LGAADLLRRA MGKKIKKEME EQEEIFVKGA IANNISESQA KSIFATVAKF 750
    AGYGFNKAHA AAYGVISYQT AYLKANYPAE FLVACLNLEL NNHDKINLFL 800
    QEAKDSGIKI IAPNINISEG YFSVKSVIPQ AATCHPQGPL CHPRVGGYPE 850
    KVKTVLNHES MKMDSRFCGN DIKGSRNDIE DTGYDKEKST IIFALGAIKG 900
    VTPNFGKLVT DERKARGAFK SITDFIERLP LKSINSKLLE NLIKSGCFDE 950
    LHDNRLQLFS SISKLLAYSA SYHAEQESNQ FSLIKVSSLS PNILIASDYA 1000
    DNNTLAFYEF ESMGLFISNH PLTQYQEIFS RLNILNTADL HNNLPDGTNR 1050
    VNLAGVIQKK DSRMSARGRF VTLVLSDPEN IFELSIFSEE VLKDYVHLLD 1100
    VKSLVVVNCD IVKDEGGIKL TAKSFSSIED AINNKQFELQ LYPQNHEELR 1150
    QIVTLLAART NNRDQSNAKA TIYLQSEGVK NFVAKITLPE KFFLQGQDFE 1200
    ILKGYSK 1207
    Length:1,207
    Mass (Da):135,675
    Last modified:July 5, 2005 - v1
    Checksum:i061B7DD575BBDD96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62095.1.
    RefSeqiYP_247260.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62095; AAY62095; RF_1244.
    GeneIDi3401355.
    KEGGirfe:RF_1244.
    PATRICi17893368. VBIRicFel64634_1496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62095.1 .
    RefSeqi YP_247260.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UK40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62095 ; AAY62095 ; RF_1244 .
    GeneIDi 3401355.
    KEGGi rfe:RF_1244.
    PATRICi 17893368. VBIRicFel64634_1496.

    Phylogenomic databases

    eggNOGi COG0587.
    HOGENOMi HOG000021784.
    KOi K02337.
    OMAi FCMDGRD.
    OrthoDBi EOG6CZQGR.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1279-MONOMER.

    Family and domain databases

    InterProi IPR011708. DNA_pol3_alpha.
    IPR029460. DNAPol_HHH.
    IPR004013. PHP_C.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view ]
    Pfami PF07733. DNA_pol3_alpha. 1 hit.
    PF14579. HHH_6. 1 hit.
    PF02811. PHP. 1 hit.
    [Graphical view ]
    SMARTi SM00481. POLIIIAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    TIGRFAMsi TIGR00594. polc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiDPO3A_RICFE
    AccessioniPrimary (citable) accession number: Q4UK40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3