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Protein

UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei260 – 2601By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide biosynthetic process Source: InterPro
  2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1280-MONOMER.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:udg
Ordered Locus Names:RF_1245
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448UDP-glucose 6-dehydrogenasePRO_0000281045Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1245.

Structurei

3D structure databases

ProteinModelPortaliQ4UK39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000153773.
KOiK00012.
OMAiAEEGVNH.
OrthoDBiEOG6ZSP7N.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UK39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDEVKISKLN KQILPIYEAK
60 70 80 90 100
LDEYLKQALE ANRLKFTNIY NNELQNAEAI FITVGTPSKE SGEADLKYVY
110 120 130 140 150
DAIDKVSEHI NKDCLIVIKS TVPPDSCSNI IAYLKSKGFS FNVASNPEFL
160 170 180 190 200
REGSAVEDFL YPDRIVVGVN NKESEEILRK IYAPLIEQGA KFVVTDLVTS
210 220 230 240 250
ELIKYASNSF LATKIAFINE MADLCEKIGG NIEDLSKGVG LDQRIGQNFL
260 270 280 290 300
NAGPGFGGSC FPKDILALNN LVENHHIDCK ILKAVIKSNK QRPSNMVDKI
310 320 330 340 350
ATLLDGDLKG KNIAVLGLTY KAGTDDVRAS PAIEIVKILL NKDVYVKAFD
360 370 380 390 400
PIGLENAKKN LEHKNLLYLD SVAEACKSVD IIVIATEWLE FKELNWQGIY
410 420 430 440
DLVKFPIVID LRNIIDNEAM KKIGFRYYAV GSKLDVIPAK AGIHYKAR
Length:448
Mass (Da):49,637
Last modified:July 4, 2005 - v1
Checksum:iEA03860BBF7FD8E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62096.1.
RefSeqiYP_247261.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62096; AAY62096; RF_1245.
KEGGirfe:RF_1245.
PATRICi17893370. VBIRicFel64634_1497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62096.1.
RefSeqiYP_247261.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UK39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_1245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY62096; AAY62096; RF_1245.
KEGGirfe:RF_1245.
PATRICi17893370. VBIRicFel64634_1497.

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000153773.
KOiK00012.
OMAiAEEGVNH.
OrthoDBiEOG6ZSP7N.

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.
BioCyciRFEL315456:GKEK-1280-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiUDG_RICFE
AccessioniPrimary (citable) accession number: Q4UK39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2007
Last sequence update: July 4, 2005
Last modified: March 31, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.