Reviewed, UniProtKB/Swiss-Prot Q4UK39 (UDG_RICFE)

Names and origin

Protein names

Recommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22

Gene names

Name:	udg
Ordered Locus Names:	RF_1245

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	UDP-glucose 6-dehydrogenase		PRO_0000281045
Regions
	Nucleotide binding	2 – 19	18	NAD Potential
Sites
	Active site	260	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UK39-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: EA03860BBF7FD8E2	FASTA	448	49,637
	10 20 30 40 50 60 MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDEVKISKLN KQILPIYEAK LDEYLKQALE 70 80 90 100 110 120 ANRLKFTNIY NNELQNAEAI FITVGTPSKE SGEADLKYVY DAIDKVSEHI NKDCLIVIKS 130 140 150 160 170 180 TVPPDSCSNI IAYLKSKGFS FNVASNPEFL REGSAVEDFL YPDRIVVGVN NKESEEILRK 190 200 210 220 230 240 IYAPLIEQGA KFVVTDLVTS ELIKYASNSF LATKIAFINE MADLCEKIGG NIEDLSKGVG 250 260 270 280 290 300 LDQRIGQNFL NAGPGFGGSC FPKDILALNN LVENHHIDCK ILKAVIKSNK QRPSNMVDKI 310 320 330 340 350 360 ATLLDGDLKG KNIAVLGLTY KAGTDDVRAS PAIEIVKILL NKDVYVKAFD PIGLENAKKN 370 380 390 400 410 420 LEHKNLLYLD SVAEACKSVD IIVIATEWLE FKELNWQGIY DLVKFPIVID LRNIIDNEAM 430 440 KKIGFRYYAV GSKLDVIPAK AGIHYKAR

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY62096.1.
RefSeq	YP_247261.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3401356.
GenomeReviews	Gene locus RF_1245 in contig CP000053_GR.
KEGG	rfe:RF_1245.
NMPDR	fig|315456.3.peg.1245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UK39.
OMA	Q4UK39. FADDEAQ.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_1245-MON.
BRENDA	1.1.1.22. 297363.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR03026. NDP-sugDHase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UDG_RICFE

Accession

Primary (citable) accession number: Q4UK39

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)