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Q4UK35

- SYS_RICFE

UniProt

Q4UK35 - SYS_RICFE

Protein

Serine--tRNA ligase

Gene

serS

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).UniRule annotation

    Catalytic activityi

    ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).UniRule annotation
    ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei282 – 2821SerineUniRule annotation
    Binding sitei382 – 3821SerineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi259 – 2613ATPUniRule annotation
    Nucleotide bindingi346 – 3494ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. serine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. selenocysteine biosynthetic process Source: UniProtKB-HAMAP
    2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway
    3. seryl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1284-MONOMER.
    UniPathwayiUPA00906; UER00895.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine--tRNA ligaseUniRule annotation (EC:6.1.1.11UniRule annotation)
    Alternative name(s):
    Seryl-tRNA synthetaseUniRule annotation
    Short name:
    SerRSUniRule annotation
    Seryl-tRNA(Ser/Sec) synthetaseUniRule annotation
    Gene namesi
    Name:serSUniRule annotation
    Ordered Locus Names:RF_1249
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Serine--tRNA ligasePRO_0000278054Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. The tRNA molecule binds across the dimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_1249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UK35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni228 – 2303Serine bindingUniRule annotation

    Domaini

    Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0172.
    HOGENOMiHOG000035938.
    KOiK01875.
    OMAiAIAMSVP.
    OrthoDBiEOG61KBH9.

    Family and domain databases

    Gene3Di1.10.287.40. 1 hit.
    HAMAPiMF_00176. Ser_tRNA_synth_type1.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR002317. Ser-tRNA-ligase_type_1.
    IPR015866. Ser-tRNA-synth_1_N.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PANTHERiPTHR11778. PTHR11778. 1 hit.
    PfamiPF02403. Seryl_tRNA_N. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
    PRINTSiPR00981. TRNASYNTHSER.
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00414. serS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UK35-1 [UniParc]FASTAAdd to Basket

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    MLNIKWIREN QELFDEKLSQ RFIEPMSSKI AMLDGEKRKI TCLIQEFQHA    50
    RKVKSKILGN MASKSGEEFE GLQRDVKHIN EKLEELEQDL NNNNELNELL 100
    NMLPNIPDEE VPYGMDESMN KLVRTYGETN PNALNKQHFE LGTKLNLMDF 150
    EQTAKISGAR FVTLKGDLAK LERALINFMI DVHTKEFDFF EISPPVLVRD 200
    NAMYNAGQLP KFAEESFATT NGYRLIPTAE VSLVNIVADT IIPREKLPMR 250
    YVAYTPCFRS EAGSSGRDTR GMIRLHQFGK VELVSITTTE ESKNEHEYIT 300
    NASETILQKL NLPYRVMLLC TGDMGFAAKK TYDIEVWLPG QKQYREIASC 350
    SNCGDFQARR MKARYKEFGS NETTLVHTLN ASGLPIGRTM VAILENYQNE 400
    DGSITIPDVL INYMGGLQKI TTYSE 425
    Length:425
    Mass (Da):48,487
    Last modified:July 5, 2005 - v1
    Checksum:i24E98FDF504BB9B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62100.1.
    RefSeqiYP_247265.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62100; AAY62100; RF_1249.
    GeneIDi3401360.
    KEGGirfe:RF_1249.
    PATRICi17893378. VBIRicFel64634_1501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62100.1 .
    RefSeqi YP_247265.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UK35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62100 ; AAY62100 ; RF_1249 .
    GeneIDi 3401360.
    KEGGi rfe:RF_1249.
    PATRICi 17893378. VBIRicFel64634_1501.

    Phylogenomic databases

    eggNOGi COG0172.
    HOGENOMi HOG000035938.
    KOi K01875.
    OMAi AIAMSVP.
    OrthoDBi EOG61KBH9.

    Enzyme and pathway databases

    UniPathwayi UPA00906 ; UER00895 .
    BioCyci RFEL315456:GKEK-1284-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.40. 1 hit.
    HAMAPi MF_00176. Ser_tRNA_synth_type1.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR002317. Ser-tRNA-ligase_type_1.
    IPR015866. Ser-tRNA-synth_1_N.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    PANTHERi PTHR11778. PTHR11778. 1 hit.
    Pfami PF02403. Seryl_tRNA_N. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
    PRINTSi PR00981. TRNASYNTHSER.
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00414. serS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSYS_RICFE
    AccessioniPrimary (citable) accession number: Q4UK35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3